Tissue alloantigens and transplantations

Three Closely Linked Genetic Systems Relevant to Transplantation

“…If they share one haplotype only, e.g., AC and AD, they are called haploidentical; if they have neither haplotype, e.g., AC and BD, they are said to be HL-A different [12]. Numer- ous studies have confirmed the findings that skin grafts exchanged between HL-A-identical pairs survive longer on the average than grafts between haploidentical and HL-A different pairs [14][15][16], that MLR between HL-A identical pairs shows no stimulation and that HL-A different pails stimulate MLR more than haploidentical pairs [17,18]. Other studies still being continued show that kidneys from HL-A identical donors require less immunosuppression and function better than unrelated grafts (5) and that ordinarily, a bone marrow graft from an HL-A-identical donor offers the best possibilities for a replacement therapy [19][20][21].…”

The Genetics of the HL-A System and its Implications in Transplantation

“…When the differences extend to hoth HL-A chromosomes the rate is under 56%. In order to demonstrate that it is indeed the HL-A antigens which are the transplantation antigens it is necessary to establish a correla tion between incompatibility and survival in unrelated subjects: it has been demonstrated by means of pre-immunisation that compatible and incompatible unrelated donors can be distinguished by leucocyte grouping [11,18]. Recent statistics have furnished the first correla tions between the tissue groups and the fate of renal grafts in un related subjects [3,15,22].…”

Demonstration of Leucocyte Isoantigens on Skin Cells by Means of Immune Adherence

“…At least some of these antigens are either identical with or closely related to the antigens that determine the compati bility of skin-and kidney homografts [2,10,11,12]. Thus it appeared of interest to investigate if isoantigens, common to leucocytes and skin cells, can be demonstrated directly on both cell types.…”