Tissue and Renal Response to Chronic Respiratory Acidosis*

Carter, Norman W.; Seldin, Donald W.; Teng, H. C.

doi:10.1172/jci103878

Cited by 58 publications

(27 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is clear, however, that the hyperbicarbonatemia of the chronic phase is sustained by increased renal hydrogen secretion (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). This study and data from the rat (1) indicate that this process is mediated, in great part, by an increase in the intrinsic rate of bicarbonate reabsorption by the proximal tubule.…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of adaptation to chronic respiratory acidosis in the rabbit proximal tubule

Krapf

1989

Journal of Critical Care

View full text Add to dashboard Cite

The hyperbicarbonatemia of chronic respiratory acidosis is maintained by enhanced bicarbonate reabsorption in the proximal tubule. To investigate the cellular mechanisms involved in this adaptation, cell and luminal pH were measured microfluorometrically using (2M,7')-bis(carboxyethyl)-(5,6)-carboxyfluorescein in isolated, microperfused S2 proximal convoluted tubules from control and acidotic rabbits. Chronic respiratory acidosis was induced by exposure to 10% CO2 for 52-56 h. Tubules from acidotic rabbits had a significantly lower luminal pH after 1-mm perfused length (7.03±0.09 vs. 7.26±0.06 in controls, perfusion rate = 10 nl/min). Chronic respiratory acidosis increased the initial rate of cell acidification (dpH1/dt) in response to luminal sodium removal by 63% and in response to lowering luminal pH (7.4-6.8) by 69%. Chronic respiratory acidosis also increased dpH,/dt in response to peritubular sodium removal by 63% and in response to lowering peritubular pH by 73%. In conclusion, chronic respiratory acidosis induces a parallel increase in the rates of the luminal Na/H antiporter and the basolateral Na/(HCO3)3 cotransporter. Therefore, the enhanced proximal tubule reabsorption of bicarbonate in chronic respiratory acidosis may be, at least in part, mediated by a parallel adaptation of these transporters.

show abstract

Section: Discussionmentioning

confidence: 99%

Mechanisms of adaptation to chronic respiratory acidosis in the rabbit proximal tubule

Krapf

1989

Journal of Critical Care

View full text Add to dashboard Cite

show abstract

“…The time required to produce severe potassium deficiency in the rat was 10 co finite period of time would be required for such changes to occur. It seems possible therefore, that if K deficiency were maintained for a sufficiently long period of time in the rat, the apparent "species difference" between the rat and the dog could well disappear.…”

Section: Discussionmentioning

confidence: 99%

“…Together with an appropriate control group, 10 male Sprague-Dawley rats were made severely potassium deficient utilizing an electrolyte-deficient diet previously described (10). Each rat undergoing depletion received 1 mM of sodium sulfate and was given 5 mg of Doca (deoxycorticosterone acetate) into the front leg muscle daily.…”

Section: Methodsmentioning

confidence: 99%

Skeletal Muscle Resting Membrane Potential in Potassium Deficiency

Bilbrey¹,

Herbin²,

Carter³

et al. 1973

J. Clin. Invest.

Self Cite

View full text Add to dashboard Cite

“…Specimens were collected into receptacles containing 0.5 ml 6 N HC1 and processed as described elsewhere (37). To maximize recovery of ammonia (38), urines in later experiments were secured under light mineral oil. Urinary total nitrogen (39), urea (22), creatinine (23), ammonia (40), and phosphorus (29) (Table II).…”

Section: Gluconeogenesis From Labeled Pyruvate In Vivomentioning

confidence: 99%

Carbohydrate metabolism in pregnancy

Herrera¹,

Knopp²,

Freinkel³

1969

J. Clin. Invest.

227

View full text Add to dashboard Cite

A B S T R A C T The effects of late pregnancy on metabolic fuels, liver composition, gluconeogenesis, and nitrogen metabolism have been examined in fed and fasted rats.Plasma free fatty acid (FFA) and immunoreactive insulin (IRI) are greater and glucose and ketones are lower in fed 19-day pregnant than they are in agematched virgin rats. A 48 hr fast elicits greater increases in FFA and ketones and more profound reductions in glucose in the pregnant rats and obliterates the differences in IRI. Fetal weight is not modified by such fasting but maternal weight losses exceed that of the nongravid rats.Livers from rats 19 days pregnant contain more and larger hepatocytes. Per /Amole hepatic deoxyribonucleic acid (DNA) -phosphorus, water and protein are more abundant, whereas glycogen is unaffected. Livers from fed pregnant rats contain more lipid phosphorus and less neutral lipid fatty acid. After a 48 hr fast, hepatic steatosis supervenes in gravid animals due to accumulated neutral fat. The contents of hepatic acetyl-coenzyme A (CoA) and citric acid are not different in fed pregnant and virgin rats but are greater in the pregnant rats after fasting.

show abstract

Tissue and Renal Response to Chronic Respiratory Acidosis*

Cited by 58 publications

References 29 publications

Mechanisms of adaptation to chronic respiratory acidosis in the rabbit proximal tubule

Mechanisms of adaptation to chronic respiratory acidosis in the rabbit proximal tubule

Skeletal Muscle Resting Membrane Potential in Potassium Deficiency

Carbohydrate metabolism in pregnancy

Contact Info

Product

Resources

About