Tissue and serum prolidase activity in patients with nasal polyposis

Salihoğlu, Murat; Güngör, Atila; Özcan, Ömer; Çeşmeci, Enver; Müftüoğlu, Tuba; İpçioğlu, Osman Metin

doi:10.5455/gulhane.168323

Cited by 3 publications

(2 citation statements)

References 19 publications

(28 reference statements)

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“…Prolidase, which belongs to the family of hydrolases and is involved in collagen degradation and synthesis, has been demonstrated as a causative factor in various diseases, such as nasal polyps and asthma [ 116 , 117 ]. In a study of 25 patients with chronic tinnitus with normal hearing, low serum prolidase enzyme activity was noted in patients with tinnitus [ 109 ].…”

Section: Biomarkers In Chronic Subjective Tinnitusmentioning

confidence: 99%

Objective and Measurable Biomarkers in Chronic Subjective Tinnitus

Kang

Kim

Park

et al. 2021

IJMS

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Tinnitus is associated with increased social costs and reduced quality of life through sleep disorders or psychological distress. The pathophysiology of chronic subjective tinnitus, which accounts for most tinnitus, has not been clearly elucidated. This is because chronic subjective tinnitus is difficult to evaluate objectively, and there are no objective markers that represent the diagnosis or therapeutic effect of tinnitus. Based on the results of studies on patients with chronic subjective tinnitus, objective and measurable biomarkers that help to identify the pathophysiology of tinnitus have been summarized. A total of 271 studies in PubMed, 303 in EMBASE, and 45 in Cochrane Library were found on biomarkers related to chronic subjective tinnitus published until April 2021. Duplicate articles, articles not written in English, review articles, case reports, and articles that did not match our topic were excluded. A total of 49 studies were included. Three specimens, including blood, saliva, and urine, and a total of 58 biomarkers were used as indicators for diagnosis, evaluation, prognosis, and therapeutic effectiveness of tinnitus. Biomarkers were classified into eight categories comprising metabolic, hemostatic, inflammatory, endocrine, immunological, neurologic, and oxidative parameters. Biomarkers can help in the diagnosis, measure the severity, predict prognosis, and treatment outcome of tinnitus.

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Section: Biomarkers In Chronic Subjective Tinnitusmentioning

confidence: 99%

Objective and Measurable Biomarkers in Chronic Subjective Tinnitus

Kang

Kim

Park

et al. 2021

IJMS

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show abstract

“… 4 It is thought that changes in the activity of prolidase enzyme may play a role in the development of many diseases such as nasal polyps, schizophrenia, anxiety, bipolar disorder, major depression, Type2 diabetes mellitus, chronic hepatitisC, osteoporosis, bronchial asthma and liver fibrosis. 5 , 6 , 7 , 8 , 9 , 10 , 11 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of serum prolidase enzyme activity and oxidative stress in patients with tinnitus

Ekinci

Kamaşak

2020

Brazilian Journal of Otorhinolaryngology

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The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps

Ekinci

Kayadibi

Demir

et al. 2021

Turkish Journal of Biochemistry

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Objective To compare prolidase enzyme activity (PEA) in serum and polyp specimens of patients with nasal polyps obtained before and after the oral steroid therapy. Materials and methods Thirty three patients with nasal polyps (39 ± 13 years) received 1 mg/kg of oral steroids. Serum samples were collected from each patient, but nasal polyp specimens could be obtained only from 23 patients (38 ± 13 years) before and after the oral steroid therapy. PEA was measured by ELISA method. Results Serum PEA values were 210 (176–242) U/L and 184 (147–217) U/L before and after the oral steroid therapy, respectively (p = 0.015). Polyp tissue PEA was 1337 (738–2130) U/g and 871 (590–1663) U/g before and after the oral steroid therapy, respectively (p = 0.429). Conclusion In patients with nasal polyps, significantly lower serum PEA after the oral steroid therapy may be a consequence of the role of prolidase enzyme in inflammatory processes which are important for the development of nasal polyps. More comprehensive studies with larger sample sizes are needed to elucidate the role of PEA in the pathogenesis of nasal polyps.

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Tissue and serum prolidase activity in patients with nasal polyposis

Cited by 3 publications

References 19 publications

Objective and Measurable Biomarkers in Chronic Subjective Tinnitus

Objective and Measurable Biomarkers in Chronic Subjective Tinnitus

Evaluation of serum prolidase enzyme activity and oxidative stress in patients with tinnitus

The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps

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