Tissue characterization and calcification potential of commercial bioprosthetic heart valves

Cunanan, Crystal; Cabiling, Christine; Dinh, Tan T; Shen, Shih‐Hwa; Tran-Hata, Phihoa; Rutledge, James H; Fishbein, Michael C.

doi:10.1016/s0003-4975(01)02493-6

Cited by 79 publications

(56 citation statements)

References 9 publications

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“…McGonagle-Wolff and Schoen [52] reported noncalcific tears as the main cause of Mitroflow valve failure followed by calcification. Cunanan et al [7] found a positive correlation between the phospholipid content of the valve and its tendency to calcify. As the Mitroflow valves have the highest levels of phospholipids in comparison to other BHVs, they are more prone to calcification.…”

Section: Modes Of Failurementioning

confidence: 98%

“…It also leads to membrane damage leading to calcium influx [6]. This calcium combines with membrane phospholipids, and in the presence of mechanical stress leads to calcium phosphate crystal nucleation, crystal growth, and valve failure due to tears and stenosis [7]. The concentration of glutaraldehyde used has gradually been decreased to 0.2% v/v, in an effort to reduce these changes, without compromising quality.…”

Section: Fixation In Glutaraldehydementioning

confidence: 99%

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Bioprosthetic Heart Valves: Impact of Implantation on Biomaterials

2013

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Prosthetic heart valves are commonly used in the treatment of valvular heart disease. Mechanical valves are more durable than the bioprosthetic valves; however, the need for long-term anticoagulant therapy renders them unsuitable for some patient groups. In this paper we discuss the different types and models of bioprosthesis, and in particular, pericardial bioprosthesis. We also discuss the preimplantation preparation processes, as well as their postimplantation changes and modes of failure.

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Section: Modes Of Failurementioning

confidence: 98%

Section: Fixation In Glutaraldehydementioning

confidence: 99%

Bioprosthetic Heart Valves: Impact of Implantation on Biomaterials

2013

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“…74 Porcine aortic valves produced by Edwards are treated with the patented XenoLogiX treatment which has shown to result in low rates of calcification. 22 The bovine pericardial Carpentier-Edwards PERIMOUNT TM , which is the second generation line of valves, show excellent durability compared to the first generation pericardial valves (Fig. 3).…”

Section: Bioprosthetic Heart Valvesmentioning

confidence: 99%

“…54 The Prima Plus Stentless Porcine Bioprosthesis is a biograft, a bioprosthesis plus homograft that has exhibited excellent long-term outcomes and maintains optimal hemodynamics. 22,42 Due to the popularity of Edwards' aortic valves, and the fact that the entire aortic pericardial portfolio is built on the PERIMOUNT design, there is a large volume of clinical follow-up on patients in whom Edwards' valves have been implanted. One large study from France followed 1133 patients who over 18 years had a valve from the PERIMOUNT family in their aortic position.…”

Section: Bioprosthetic Heart Valvesmentioning

confidence: 99%

Emerging Trends in Heart Valve Engineering: Part II. Novel and Standard Technologies for Aortic Valve Replacement

et al. 2014

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Abstract-The engineering of technologies for heart valve replacement (i.e., heart valve engineering) is an exciting and evolving field. Since the first valve replacement, technology has progressed by leaps and bounds. Innovations emerge frequently and supply patients and physicians with new, increasingly efficacious and less invasive treatment options. As much as any other field in medicine the treatment of heart valve disease has experienced a renaissance in the last 10 years. Here we review the currently available technologies and future options in the surgical and transcatheter treatment of aortic valve disease. Different valves from major manufacturers are described in details with their applications.

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“…Bioprostheses present a hemodynamic profile even better, however, both replacement valves made from porcine aortic valves and bovine pericardium fixed in glutaraldehyde induce activation of the immune system [6,7], triggering an inflammatory reaction [7,8] that leads to infiltration of the collagen matrix, rupture of the collagen-elastin network and calcification [9][10][11]. These events invariably result in valvar dysfunction and the necessity of reoperation [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Comparação entre o pericárdio bovino decelularizado e o pericárdio bovino convencional utilizado na confecção de biopróteses valvares cardíacas

Costa¹,

Pomerantzeff²,

Braile³

et al. 2005

Rev Bras Cir Cardiovasc

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Introduction: In this paper, our objective was to compare the decellularized and conventional pericardium mechanical resistance and also its capability of inducing inflammatory response in an animal experimental model.Methods: In order to study these properties, we divided the pericardia into two groups: Group I -pericardium conventionally treated with GTA and Group II -pericardium previously decellularized and then treated with GTA in the conventional way. After the chemical treatment, Group II samples were histologically evaluated to confirm the efficacy of the decellularization process. Then, only for the analysis of mechanical resistance, pericardia were divided in: Groups 1 (conventional pericardia with criteria of approval), 2 (conventional pericardial with criteria of rejection) and 3 (decellularized pericardia). The capacity of inducing inflammatory response was tested in a rat experimental model using 50 Wistar rats, in which rats of each group received patches of the pericardia in the abdomen. Our third step of analysis was to manufacture three decellularized pericardium bioprostheses which were submitted to hydrodynamic evaluation together with a conventional bioprosthesis test.Results: The histological analysis showed complete decellularization. Mechanical resistance gave statistical differences in the "tension of rupture" and "tenacity index" tests. We found no difference in the inflammatory activity in the animal model. Hydrodynamic performance was similar and all prostheses reached 150 million cycles. The final histological analysis assessed the standard microscopic pattern and no rupture or abnormal fragmentation was caused by mechanical stress. Conclusion:The decellularization technique maintains the physical resistance of the pericardium when compared with the conventionally prepared pericardium. And also, there was no difference in both groups regarding to inflammatory response studied in the animal model. Descriptors: Heart valve prosthesis. Bioprosthesis. Pericarduim. Comparative study. Comparação entre o pericárdio bovino decelularizado e o pericárdio bovino convencional utilizado na confecção de biopróteses valvares cardíacasComparison between the decellularized bovine pericardium and the conventional bovine pericardium used in the manufacture of cardiac bioprostheses 15 COSTA, JNL ET AL -Comparison between the decellularized bovine pericardium and the conventional bovine pericardium used in the manufacture of cardiac bioprostheses Braz J Cardiovasc Surg 2005; 20(1):14-22

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Tissue characterization and calcification potential of commercial bioprosthetic heart valves

Cited by 79 publications

References 9 publications

Bioprosthetic Heart Valves: Impact of Implantation on Biomaterials

Bioprosthetic Heart Valves: Impact of Implantation on Biomaterials

Emerging Trends in Heart Valve Engineering: Part II. Novel and Standard Technologies for Aortic Valve Replacement

Comparação entre o pericárdio bovino decelularizado e o pericárdio bovino convencional utilizado na confecção de biopróteses valvares cardíacas

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