Tissue distribution of Dechlorane Plus and its dechlorinated analogs in contaminated fish: High affinity to the brain for anti-DP

Zhang, Ying; Wu, Jiangping; Luo, Xiao-Jun; Wang, Jing; Chen, She-Jun; Mai, Bi-Xian

doi:10.1016/j.envpol.2011.07.026

Cited by 56 publications

(79 citation statements)

References 35 publications

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“…The concentrations in air, dust and sediment were generally low or even undetectable in most cases, especially for anti-Cl 10 -DP (Chen et al, 2011;Peng et al, 2014;Zeng et al, 2014;Zhao et al, 2011;Zheng et al, 2010). The exception was that relatively higher levels of anti-Cl 11 -DP were observed in ewaste recycling areas in South China, such as in air (3.68-671 pg m −3 , Chen et al, 2011), indoor dust (nd-20.2 ng g − 1 , Zheng et al, 2010) and sediment (6.32-25.0 ng g −1 dw, Zhang et al, 2011b). Interestingly, anti-Cl 11 -DP was observed in air samples at concentrations b 0.1 pg m −3 from East Asia to the Arctic .…”

Section: Dp Dechlorinated Analogsmentioning

confidence: 96%

“…Therefore, these two hypotheses are still needed to be confirmed. DP dechlorination products were commonly reported in biota including human tissues, the levels were generally much lower than those of DP (Ben et al, 2013;Chen et al, 2011Chen et al, , 2013aGuerra et al, 2011;Mo et al, 2013;Muñoz-Arnanz, et al, 2011Peng et al, 2012Peng et al, , 2014Sun et al, 2012;Yan et al, 2012;Zhang et al, 2011b;Zheng et al, 2010Zheng et al, , 2014. However, an extremely high level was observed in a fresh water food web around DP facility in Huai'an, China, where the concentrations of anti-Cl 10 -DP and anti-Cl 11 -DP was 84.4 ng g −1 lw and 1030 ng g −1 lw, respectively .The dechlorinated products of DP in biota were mainly attributed to accumulation from the external habitat environment rather than internal metabolism, although the gender difference observed in some cases suggested that anti-Cl 11 -DP in the human body may be partly formed from in vivo dechlorination of the anti-isomer (Yan et al, 2012).…”

Section: Dp Dechlorinated Analogsmentioning

confidence: 97%

“…It was also reported that alumina and Florisil columns, as well as commercial SPE column (i.e., Oasis® HLB) were effective (Cequier et al, 2015;Zhang et al, 2011b;Zheng et al, 2015a). Florisil column was also used to separate Dechloranes from hexabromocyclododecane (HBCD) (Ismail et al, 2009), while a column containing 3.5% (w/w) water deactivated silica gel could separate DP and brominated flame retardants (BFRs) from organophosphate esters (OPEs) (Salamova et al, 2014).…”

Section: Sample Extraction and Clean-upmentioning

confidence: 99%

“…Chromatographic separation was usually achieved using capillary gas chromatography (GC) columns with a non-polar stationary phase, such as DB-5MS (De la Hoh et al, 2006;Jia et al, 2011;Ren et al, 2008;Zeng et al, 2014;Zhang et al, 2013;Zheng et al, 2015a), DB-5HT (Muñoz-Arnanz et al, 2011), DB-XLB (Chen et al, 2013a(Chen et al, , 2013bMo et al, 2013;Yan et al, 2012;Zhang et al, 2011b), CP-Sil 13 CB , VF-5MS (Peng et al, , 2014, Rxi-5MS (Qiu and Hites, 2008) and Rtx-1614 (Ben et al, 2013;Peverly et al, 2015). The 15 m and 30 m columns were generally selected.…”

Section: Instrumental Analysis and Quantificationmentioning

confidence: 99%

“…These global observations indicated that high levels of DP generally occurred in the source areas, such as the North American Great Lakes and Huai'an City in China, e-waste dismantling areas in South China and urban areas in the world as discussed in the previous section. The highest concentrations of DP could be up to several ng m −3 in ambient air and μg g −1 dw in soil close to the DP manufacturing facility in Huai'an City and μg g −1 dw in sediment from an e-waste recycling site in South China (Zhang et al, 2011b). On the other hand, more evidence from all over the world has led to the vision that DP is a worldwide contaminant (Feo et al, 2012;Möller et al, 2010Möller et al, , 2011Möller et al, , 2012aSverko et al, 2011a, Vorkamp andRigét, 2014;Wolschke et al, 2015).…”

Section: Global Distributionmentioning

confidence: 99%

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Sources and environmental behaviors of Dechlorane Plus and related compounds — A review

Wang

Zhang

et al. 2016

Environment International

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Although Dechlorane Plus (DP) has been used as a polychlorinated flame retardant for almost half a century, its detection in the environment was not reported until 2006. The subsequent intensive research has confirmed its global ubiquity. A few reviews have presented the properties, analytical methods and environmental occurrence of DP and related compounds in the past several years. The present review emphasizes on the environmental behavior of DP isomers which is assessed by the variation of the isomer ratio of DP in various matrices. Other aspects including the analytical methods, emission sources, general environmental occurrence and bioaccumulation of DP are also summarized. In this review, three typical emission sources in the environment are categorized after introducing the measurement method of DP. The temporal-spatial distribution is then evaluated at the global scale, which provides an integrated representation of the environmental occurrence of DP and potential impact on the human health and ecosystems. The variations of DP isomer ratio in various matrices reinforce its source related distribution and their stereoselective bioaccumulation. Thereafter, DP related compounds and dechlorinated analogs are briefly summarized in regards to their occurrence in various matrices, suggesting their ubiquity in the environment and bioavailability. Further studies are required to better assess the exposures and toxicological effects of DP and its analogs. A special concern is the serious contamination in e-waste recycling areas in developing countries, where long-term monitoring data on the association of DP exposure and adverse effects to human health and ecosystems is urgently needed.

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Section: Dp Dechlorinated Analogsmentioning

confidence: 96%

Section: Dp Dechlorinated Analogsmentioning

confidence: 97%

Section: Sample Extraction and Clean-upmentioning

confidence: 99%

Section: Instrumental Analysis and Quantificationmentioning

confidence: 99%

Section: Global Distributionmentioning

confidence: 99%

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Sources and environmental behaviors of Dechlorane Plus and related compounds — A review

Wang

Zhang

et al. 2016

Environment International

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Concentrations and trends of halogenated flame retardants in the pooled serum of residents of Laizhou Bay, China

Jin

et al. 2013

Enviro Toxic and Chemistry

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The south coast of Laizhou Bay, in northeastern China, is a production area for halogenated flame retardants (HFR). In 2007, the authors measured serum concentrations of polybrominated diphenyl ethers (PBDEs) in Laizhou Bay residents. To assess the PBDE concentration trend, and determine the concentrations of the emerging flame retardants Dechlorane Plus (DP) and bis(2-ethylhexyl)-3,4,5,6-tetrabromophthalate (TBPH), the authors measured the concentrations of 8 PBDE congeners, 2 DP isomers, and TBPH in 10 composite samples, which were pooled from the serum collected from 305 Laizhou Bay residents in October 2011. The average concentration of the total PBDE (∑8 PBDE) concentration in all serum pools was 240 ng/g lipid weight, and the highest serum pool concentration (in the 30- to 39-yr-old male group) was 780 ng/g lipid weight. Brominated diphenyl ether-209 was the dominant congener, accounting for 87% of ∑8 PBDE. Compared with a previous study, ∑8 PBDE serum concentrations in the present study showed no change in order of magnitude, but the relative contribution of BDE-209 to ∑8 PBDE was higher. The average concentration of ∑DP in all serum pools was 3.6 ng/g lipid weight, ranging from 1.4 ng/g lipid weight (in the 50- to 59-yr-old male group) to 11 ng/g lipid weight (in the 20- to 29-yr-old male group). The concentration of DP was lower than in other reported studies. The study also detected TBPH in the 30- to 39-yr-old female group, suggesting that TBPH, as an emerging HFR, requires further monitoring.

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Accumulation and effects of 90‐day oral exposure to Dechlorane Plus in quail (Coturnix coturnix)

Zhu

et al. 2013

Enviro Toxic and Chemistry

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While a number of studies have addressed bioaccumulation of the flame retardant Dechlorane Plus (DP), little information is available regarding the adverse effects of DP on animals, especially on bird species. In the present study, male common quails (Coturnix coturnix) were consecutively exposed to commercial DP-25 by gavage for 90 d at 1-mg/kg/d, 10-mg/kg/d, and 100-mg/kg/d dosages. Concentrations of DP isomers in liver, muscle, and serum were determined after exposure. Liver enzyme activity involved in xenobiotic biotransformation processes and oxidative stress was measured, as well as glutathione and maleic dialdehyde content. The results showed that DP was more prone to accumulate in the liver than in muscle and serum in all exposed groups. In tested tissues, syn-DP dominated in the high-exposure groups (10 and 100 mg/kg/d), whereas anti-DP tended to accumulate in the low-exposure group (1 mg/kg/d). The concentration ratios of anti-DP to total DP (fanti values) in the tissues examined were close to commercial DP in the low-exposure group; however, the fanti values were significantly decreased in the high-exposure groups. Enzyme activity of 7-pentoxyresorufin-O-demethylase (PROD) decreased significantly in all exposed groups compared with the control group, whereas activity of erythromycin N-demethylase (ERND) and the antioxidant enzyme catalase significantly increased in high-exposure groups. The results implied that DP exposure levels influenced isomeric compositions in organs and that DP exposure altered hepatic alkoxyresorufin O-dealkylase (AROD) activity and contributed to the biological effects of DP.

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Tissue distribution of Dechlorane Plus and its dechlorinated analogs in contaminated fish: High affinity to the brain for anti-DP

Cited by 56 publications

References 35 publications

Sources and environmental behaviors of Dechlorane Plus and related compounds — A review

Sources and environmental behaviors of Dechlorane Plus and related compounds — A review

Concentrations and trends of halogenated flame retardants in the pooled serum of residents of Laizhou Bay, China

Accumulation and effects of 90‐day oral exposure to Dechlorane Plus in quail (Coturnix coturnix)

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