Tissue Engineering for Gastrointestinal and Genitourinary Tracts

Elia, Elissa; Brownell, David; Chabaud, Stéphane; Bolduc, Stéphane

doi:10.3390/ijms24010009

Cited by 5 publications

(4 citation statements)

References 281 publications

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“…However, they raise multiple issues regarding cell viability during processing, host cells compatibility and sourcing 159 , and custody from fabrication to implantation. Although a few pre-cellularized muscular layer models will be cited, this section will mostly focus on acellular scaffolds, in particular since these impose far less logistics hurdles.…”

Section: The Muscular Outer Layermentioning

confidence: 99%

Biomimetic materials to replace tubular tissues

Martinier,

Trichet,

Fernandes

2024

Preprint

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Repairing tubular tissues—the trachea, the esophagus, urinary and gastrointestinal tracts, and the circulatory system—from trauma or severe pathologies that require resection, calls for new, more effective graft materials. Currently, the relatively narrow family of materials available for these applications relies on synthetic polymers that fail to reproduce the biological and physical cues found in native tissues. Mimicking the structure and the composition of native tubular tissues to elaborate functional grafts is expected to outperform the materials currently in use, but remains one of the most challenging goals in the field of biomaterials. Despite their apparent diversity, tubular tissues share extensive compositional and structural features. Here, we assess the current state of the art through a dual layer model, reducing each tissue to an inner epithelial layer and an outer muscular layer. Based on this model, we examine the current strategies developed to mimic each layer and we underline how each fabrication method stands in providing a biomimetic material for future clinical translation. The analysis provided here, addressed to materials chemists, biomaterials engineers and clinical staff alike, sets new guidelines to foster the elaboration of new biomimetic materials for effective tubular tissue repair.

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Section: The Muscular Outer Layermentioning

confidence: 99%

Biomimetic materials to replace tubular tissues

Martinier,

Trichet,

Fernandes

2024

Preprint

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“…These constructs lack tissue-specific biological cues, and in most cases, the vaginal epithelium is not fully differentiated. Therefore, developing a fully autol-ogous vaginal 3D scaffold provides an excellent opportunity for vaginal reconstruction or modeling of its diseases [8,181]. In this regard, Orabi et al developed a tissue-engineered vagina using the self-assembly method and autologous vaginal cells [181].…”

Section: Self-assembled Fibrous Scaffolds For Vagina Reconstructionmentioning

confidence: 99%

“…Therefore, developing a fully autol-ogous vaginal 3D scaffold provides an excellent opportunity for vaginal reconstruction or modeling of its diseases [8,181]. In this regard, Orabi et al developed a tissue-engineered vagina using the self-assembly method and autologous vaginal cells [181]. Vaginal stroma was prepared by culturing vaginal stromal cells in the presence of ascorbic acid.…”

Section: Self-assembled Fibrous Scaffolds For Vagina Reconstructionmentioning

confidence: 99%

Extracellular Matrix-Based and Electrospun Scaffolding Systems for Vaginal Reconstruction

et al. 2023

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Congenital vaginal anomalies and pelvic organ prolapse affect different age groups of women and both have significant negative impacts on patients’ psychological well-being and quality of life. While surgical and non-surgical treatments are available for vaginal defects, their efficacy is limited, and they often result in long-term complications. Therefore, alternative treatment options are urgently needed. Fortunately, tissue-engineered scaffolds are promising new treatment modalities that provide an extracellular matrix (ECM)-like environment for vaginal cells to adhere, secrete ECM, and be remodeled by host cells. To this end, ECM-based scaffolds or the constructs that resemble ECM, generated by self-assembly, decellularization, or electrospinning techniques, have gained attention from both clinicians and researchers. These biomimetic scaffolds are highly similar to the native vaginal ECM and have great potential for clinical translation. This review article aims to discuss recent applications, challenges, and future perspectives of these scaffolds in vaginal reconstruction or repair strategies.

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“…Hollow organs from the gastrointestinal and genitourinary tract share a similar overall histological composition with a luminal epithelium covering layers of connective- and muscular tissues [ 4 ]. These organs are less complex to engineer than solid organs, possibly due to better vascularization, reduced thickness that enables passive diffusion, and the better availability of biomimetic scaffolds [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

A perioperative layered autologous tissue expansion graft for hollow organ repair

Willacy,

Juul,

Taouzlak

et al. 2024

Heliyon

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Tissue Engineering for Gastrointestinal and Genitourinary Tracts

Cited by 5 publications

References 281 publications

Biomimetic materials to replace tubular tissues

Biomimetic materials to replace tubular tissues

Extracellular Matrix-Based and Electrospun Scaffolding Systems for Vaginal Reconstruction

A perioperative layered autologous tissue expansion graft for hollow organ repair

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