Tissue Engineering: Mechanocompatible Polymer‐Extracellular‐Matrix Composites for Vascular Tissue Engineering (Adv. Healthcare Mater. 13/2016)

Jiang, Bin; Suen, Rachel; Wang, Jiao Jing; Zhang, Zheng Jenny; Wertheim, Jason A.

doi:10.1002/adhm.201670067

Cited by 3 publications

(3 citation statements)

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“…[21] These groups are critical stimulants of stem cell evolution and differentiation. [22] For instance, the OH group modulates adsorption of fibronectin by altering integrin adhesion receptor binding; this may lead to enhanced osteogenesis. [23,24] Numerous studies confirm that of the aliphatic polyesters used as scaffolding materials in bone tissue engineering, poly(l-lactide-co-ε-caprolactone) (poly(LLA-co-CL)) meets many of prerequisites, such as adequate biocompatibility and degradability and tunable properties.…”

Section: Introductionmentioning

confidence: 99%

A Copolymer Scaffold Functionalized with Nanodiamond Particles Enhances Osteogenic Metabolic Activity and Bone Regeneration

Yassin

Mustafa

Xing

et al. 2017

Macromolecular Bioscience

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Functionalizing polymer scaffolds with nanodiamond particles (nDPs) has pronounced effect on the surface properties, such as improved wettability, an increased active area and binding sites for cellular attachment and adhesion, and increased ability to immobilize biomolecules by physical adsorption. This study aims to evaluate the effect of poly(l-lactide-co-ε-caprolactone) (poly(LLA-co-CL)) scaffolds, functionalized with nDPs, on bone regeneration in a rat calvarial critical size defect. Poly(LLA-co-CL) scaffolds functionalized with nDPs are also compared with pristine scaffolds with reference to albumin adsorption and seeding efficiency of bone marrow stromal cells (BMSCs). Compared with pristine scaffolds, the experimental scaffolds exhibit a reduction in albumin adsorption and a significant increase in the seeding efficiency of BMSCs (p = 0.027). In the calvarial defects implanted with BMSC-seeded poly(LLA-co-CL)/nDPs scaffolds, live imaging at 12 weeks discloses a significant increase in osteogenic metabolic activity (p = 0.016). Microcomputed tomography, confirmed by histological data, reveals a substantial increase in bone volume (p = 0.021). The results show that compared with conventional poly(LLA-co-CL) scaffolds those functionalized with nDPs promote osteogenic metabolic activity and mineralization capacity. It is concluded that poly(LLA-co-CL) composite matrices functionalized with nDPs enhance osteoconductivity and therefore warrant further study as potential scaffolding material for bone tissue engineering.

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Section: Introductionmentioning

confidence: 99%

A Copolymer Scaffold Functionalized with Nanodiamond Particles Enhances Osteogenic Metabolic Activity and Bone Regeneration

Yassin

Mustafa

Xing

et al. 2017

Macromolecular Bioscience

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“…Wound healing [208] Citrate-based mussel-inspired bioadhesives (iCMBAs) Wound healing [148][149][209][210][211] (Continued) BPLP-PLGA Bioimaging [213] Poly (citric acid-octanediol-polyethylene glycol)(PCE)-graphene (PCEG) nanocomposites…”

Section: Materials Application Refsmentioning

confidence: 99%

Enabling Proregenerative Medical Devices via Citrate‐Based Biomaterials: Transitioning from Inert to Regenerative Biomaterials

Wang,

Huddleston,

Yang

et al. 2023

Advanced Materials

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Regenerative medicine aims to restore tissue and organ function without the use of prosthetics and permanent implants. However, achieving this goal has been elusive, and the field remains mostly an academic discipline with few products widely used in clinical practice. From a materials science perspective, barriers include the lack of proregenerative biomaterials, a complex regulatory process to demonstrate safety and efficacy, and user adoption challenges. Although biomaterials, particularly biodegradable polymers, can play a major role in regenerative medicine, their suboptimal mechanical and degradation properties often limit their use, and they do not support inherent biological processes that facilitate tissue regeneration. As of 2020, nine synthetic biodegradable polymers used in medical devices are cleared or approved for use in the United States of America. Despite the limitations in the design, production, and marketing of these devices, this small number of biodegradable polymers has dominated the resorbable medical device market for the past 50 years. This perspective will review the history and applications of biodegradable polymers used in medical devices, highlight the need and requirements for regenerative biomaterials, and discuss the path behind the recent successful introduction of citrate‐based biomaterials for manufacturing innovative medical products aimed at improving the outcome of musculoskeletal surgeries.

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“…As for toxicity concerns, polydiolcitrates have been extensively investigated as implantable materials in contact with blood and blood vessels with no deleterious effects reported . Irgacure 819 and Sudan I were chosen as a model initiator and absorber to demonstrate the feasibility of printing the stents.…”

mentioning

confidence: 99%

3D‐Printing Strong High‐Resolution Antioxidant Bioresorbable Vascular Stents

Lith¹,

Baker²,

Ware³

et al. 2016

Adv Materials Technologies

162

104

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3D‐printed stents are fabricated with high speed and resolution by micro‐continuous liquid interface production (microCLIP) of a bioresorbable, antioxidant, photopolymerizable polydiolcitrate biomaterial. Printed stents can match the mechanical properties of bare metal stents and strengthen porcine arteries after deployment. This technology is a big step forward toward on‐the‐spot and on‐demand printing of patient‐specific stents.

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Tissue Engineering: Mechanocompatible Polymer‐Extracellular‐Matrix Composites for Vascular Tissue Engineering (Adv. Healthcare Mater. 13/2016)

Cited by 3 publications

References 0 publications

A Copolymer Scaffold Functionalized with Nanodiamond Particles Enhances Osteogenic Metabolic Activity and Bone Regeneration

A Copolymer Scaffold Functionalized with Nanodiamond Particles Enhances Osteogenic Metabolic Activity and Bone Regeneration

Enabling Proregenerative Medical Devices via Citrate‐Based Biomaterials: Transitioning from Inert to Regenerative Biomaterials

3D‐Printing Strong High‐Resolution Antioxidant Bioresorbable Vascular Stents

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