2019
DOI: 10.1111/aor.13485
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Tissue engineering scaffolds in the treatment of brain disorders in geriatric patients

Abstract: The world population is ageing at an alarming rate, currently increasing at around 3% per year for people over 60 years. This fast growing demography is largely unproductive and prone to many brain disorders such as Alzheimer's disease, Parkinson's disease, and brain tumors. Currently available treatment modalities are inadequate to stop neural degeneration or to completely eradicate cancer cells. Exogenously engineered scaffolds hold great potential for in vivo brain regeneration and functional restoration.

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Cited by 6 publications
(3 citation statements)
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“…As an emerging science, tissue engineering and regenerative medicine focus on developing materials that replace, restore or improve tissues or organs and enhance the cellular capacity to proliferate, migrate and differentiate into different cell types and specific tissues, respectively [82][83][84]. Therefore, the importance of these areas of the study lies in current therapies for various diseases ranging from the regeneration of skin, blood vessels, cartilage, heart tissue, bone, brain disorders, and even further in the urinary tract or gastrointestinal tract [85][86][87][88][89][90][91].…”
Section: Modifications Of Pla As a Tissue Engineering Materialsmentioning
confidence: 99%
“…As an emerging science, tissue engineering and regenerative medicine focus on developing materials that replace, restore or improve tissues or organs and enhance the cellular capacity to proliferate, migrate and differentiate into different cell types and specific tissues, respectively [82][83][84]. Therefore, the importance of these areas of the study lies in current therapies for various diseases ranging from the regeneration of skin, blood vessels, cartilage, heart tissue, bone, brain disorders, and even further in the urinary tract or gastrointestinal tract [85][86][87][88][89][90][91].…”
Section: Modifications Of Pla As a Tissue Engineering Materialsmentioning
confidence: 99%
“…Alireza Dehqan Niri et al of the Baqiyatallah University of Medical Sciences, Tehran, Iran reviewed the status of tissue engineering scaffolds in the treatment of brain disorders in geriatric patients. Scaffolds have been successfully fabricated from a wide range of materials and techniques.…”
Section: Tissue Engineeringmentioning
confidence: 99%
“…Scaffolds should imitate the natural extracellular matrix to provide a biomimetic environment for neural development. Moreover, scaffolds must retain their structural integrity and stability during the implantation surgery [ 3 , 4 ].…”
Section: Introductionmentioning
confidence: 99%