“…Tissue engineering, the combination of scaffolds and cells, makes it feasible to analyse the effect of mechanical stimuli on cell proliferation and differentiation in vitro and to develop or optimise constructs for replacement of damaged or diseased tissues [18, 30, 47]. There is high demand for clinically applicable transplants [35], but it is not easily achievable due to the intrinsic multiparametrical complexity of tissues. Mechanostimulation is considered to be a crucial parameter for the maintenance of the metabolic and differentiation status of cells and the integrity of tissues.…”