Tissue fibroblasts are versatile immune regulators: An evaluation of their impact on the aging process

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu

doi:10.1016/j.arr.2024.102296

Ageing Research Reviews

2024

DOI: 10.1016/j.arr.2024.102296

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Tissue fibroblasts are versatile immune regulators: An evaluation of their impact on the aging process

Antero Salminen,

Kai Kaarniranta,

Anu Kauppinen

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2024

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Cited by 3 publications

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Universal Immune Learning Ability in Immune and Non-Immune Cells (A Review)

Alekseenko,

Kondratyeva,

Chernov

et al. 2024

Russ J Bioorg Chem

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Universal Immune Learning Ability in Immune and Non-Immune Cells (A Review)

Alekseenko,

Kondratyeva,

Chernov

et al. 2024

Russ J Bioorg Chem

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Inflammaging: The Next Challenge—Exploring the Role of Gut Microbiota, Environmental Factors, and Sex Differences

Caldarelli,

Rio,

Marrone

et al. 2024

Biomedicines

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The term ‘inflammaging’ has been coined to describe the chronic state of inflammation derived from ongoing cycles of tissue damage and the subsequent immune responses. This inflammatory status contributes to the decline of organs and physiological functions, accelerates the aging process, and increases the risk of age-related illnesses and death. During aging, the gut microbiota (GM) undergoes significant changes, including a decreased diversity of species, a decline in beneficial bacteria, and a rise in proinflammatory ones, resulting in persistent low-grade inflammation. Moreover, environmental factors, such as diet and medications, contribute to age-related changes in GM and immune function, preventing or promoting inflammaging. This narrative review aims to clarify the underlying mechanisms of inflammaging and to specifically investigate the influence of GM and several environmental factors on these mechanisms, while also exploring potential differences related to sex. Moreover, lifestyle and pharmacological interventions will be suggested to promote healthy aging.

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The Influence of Circadian Rhythms on DNA Damage Repair in Skin Photoaging

Su,

Hu,

et al. 2024

IJMS

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Circadian rhythms, the internal timekeeping systems governing physiological processes, significantly influence skin health, particularly in response to ultraviolet radiation (UVR). Disruptions in circadian rhythms can exacerbate UVR-induced skin damage and increase the risk of skin aging and cancer. This review explores how circadian rhythms affect various aspects of skin physiology and pathology, with a special focus on DNA repair. Circadian regulation ensures optimal DNA repair following UVR-induced damage, reducing mutation accumulation, and enhancing genomic stability. The circadian control over cell proliferation and apoptosis further contributes to skin regeneration and response to UVR. Oxidative stress management is another critical area where circadian rhythms exert influence. Key circadian genes like brain and muscle ARNT-like 1 (BMAL1) and circadian locomotor output cycles kaput (CLOCK) modulate the activity of antioxidant enzymes and signaling pathways to protect cells from oxidative stress. Circadian rhythms also affect inflammatory and immune responses by modulating the inflammatory response and the activity of Langerhans cells and other immune cells in the skin. In summary, circadian rhythms form a complex defense network that manages UVR-induced damage through the precise regulation of DNA damage repair, cell proliferation, apoptosis, inflammatory response, oxidative stress, and hormonal signaling. Understanding these mechanisms provides insights into developing targeted skin protection and improving skin cancer prevention.

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Tissue fibroblasts are versatile immune regulators: An evaluation of their impact on the aging process

Cited by 3 publications

References 243 publications

Universal Immune Learning Ability in Immune and Non-Immune Cells (A Review)

Universal Immune Learning Ability in Immune and Non-Immune Cells (A Review)

Inflammaging: The Next Challenge—Exploring the Role of Gut Microbiota, Environmental Factors, and Sex Differences

The Influence of Circadian Rhythms on DNA Damage Repair in Skin Photoaging

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