Tissue Healing during Degradation of a Long-Lasting Bioresorbable γ-Ray-Sterilised Poly(Lactic Acid) Mesh in the Rat: A 12-Month Study

Tayrac, Renaud de; Letouzey, V.; Guiraud, Isabelle; Vert, Michel; Marès, P.

doi:10.1159/000277933

Cited by 11 publications

(10 citation statements)

References 42 publications

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“…Herniation and complication rates in the abdominal hernia model differ depending on the surgery technique and material used. Previously herniation rates were reported to be 4% when testing PP meshes [17] and 53% after implantation of irradiated PLA meshes [16]. The herniation rates in this study were between 14 and 33% in a small group of animals with especially the PP/PLA hybrid meshes demonstrating lower herniation rates than expected.…”

Section: Discussionsupporting

confidence: 49%

“…The inflammatory response in PLA(94) was significantly less pronounced and collagen organisation significantly better than in PP. In a subsequent study the meshes were previously gamma-ray sterilised with 25, 75 or 125 kGy to accelerate PLA(94) degradation [16]. The higher the level of gamma-radiation, the higher the incidence of abdominal wall herniation (22.2, 31.3 and 52.6% with 25, 75 and 125 kGy, respectively).…”

Section: Introductionmentioning

confidence: 99%

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A preclinical evaluation of polypropylene/polylacticacid hybrid meshes for fascial defect repair using a rat abdominal hernia model

et al. 2017

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ObjectivesSynthetic mesh surgery for both abdominal and urogenital hernia repair is often unsatisfactory in the long-term due to postoperative complications. We hypothesized that a semi-degradable mesh hybrid may provide more appropriate biocompatibility with comparable mechanical properties. The aim was to compare its in vivo biocompatibility with a commercial polypropylene (PP) mesh.Methods72 rats were randomly allocated to either our new composite mesh (monofilament PP mesh knitted with polylactic-acid-fibers (PLA)) or to a commercially available PP mesh that was used as a control. 15, 90, and 180 days after implantation into the rat abdomen mesh tissue complexes were analysed for erosion, contraction, foreign body reaction, tissue integration and biomechanical properties.ResultsNo differences were seen in regard to clinical parameters including erosion, contraction or infection rates between the two groups. Biomechanical properties including breaking load, stiffness and deformation did not show any significant differences between the different materials at any timepoint. Macrophage staining did not reveal any significant differences between the two groups or between timepoints either. In regard to collagen I there was significantly less collagen I in the PP group compared to the PP/ PLA group at day 180. Collagen III did not show any significant differences at any timepoint between the two groups.ConclusionA PP/PLA hybrid mesh, leaving a low amount of PP after PLA degradation seems to have comparable biomechanical properties like PP at 180 days due to enhanced collagen production without significant differences in erosion, contraction, herniation or infection rates.

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Section: Discussionsupporting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

A preclinical evaluation of polypropylene/polylacticacid hybrid meshes for fascial defect repair using a rat abdominal hernia model

et al. 2017

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“…In addition to this, PLA mesh was shown to have comparable mechanical properties with polypropylene mesh 3 months after implantation in rats [ 68 ]. However, these promising findings would need to be supported by long-term in vivo testing [ 69 ].…”

Section: Materials Discussionmentioning

confidence: 99%

In vivo response to polypropylene following implantation in animal models: a review of biocompatibility

Kelly¹,

Macdougall²,

Olabisi³

et al. 2016

Int Urogynecol J

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Introduction and hypothesisPolypropylene is a material that is commonly used to treat pelvic floor conditions such as pelvic organ prolapse (POP) and stress urinary incontinence (SUI). Owing to the nature of complications experienced by some patients implanted with either incontinence or prolapse meshes, the biocompatibility of polypropylene has recently been questioned. This literature review considers the in vivo response to polypropylene following implantation in animal models. The specific areas explored in this review are material selection, impact of anatomical location, and the structure, weight and size of polypropylene mesh types.MethodsAll relevant abstracts from original articles investigating the host response of mesh in vivo were reviewed. Papers were obtained and categorised into various mesh material types: polypropylene, polypropylene composites, and other synthetic and biologically derived mesh.ResultsPolypropylene mesh fared well in comparison with other material types in terms of host response. It was found that a lightweight, large-pore mesh is the most appropriate structure.ConclusionThe evidence reviewed shows that polypropylene evokes a less inflammatory or similar host response when compared with other materials used in mesh devices.Electronic supplementary materialThe online version of this article (doi:10.1007/s00192-016-3029-1) contains supplementary material, which is available to authorized users

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“…Early preclinical experiences have been published by both de Tayrac et al [14, 15] and Klinge et al [16] but no successful long-term follow-up has been made available. The purpose of this study was to evaluate the mechanical performance and histopathological response of a synthetic long‐term resorbable mesh with a novel time-dependent mechanical behavior, TIGR ® Matrix Surgical Mesh (test), compared to a nonresorbable polypropylene mesh (control) during long-term functional implantation in sheep abdominal wall.…”

Section: Introductionmentioning

confidence: 99%

Three-year results from a preclinical implantation study of a long-term resorbable surgical mesh with time-dependent mechanical characteristics

Hjort¹,

Mathisen²,

Alves

et al. 2011

Hernia

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PurposeThe purpose of this study was to evaluate the biocompatibility, local tissue effects and performance of a synthetic long-term resorbable test mesh (TIGR® Matrix Surgical Mesh) compared to a non-resorbable polypropylene control mesh following implantation in a sheep model.MethodsFull-thickness abdominal wall defects were created in 14 sheep and subsequently repaired using test or control meshes. Sacrifices were made at 4, 9, 15, 24 and 36 months and results in terms of macroscopic observations, histology and collagen analysis are described for 4, 9, 15, 24 and 36 months.ResultsThe overall biocompatibility was good, and equivalent in the test and control meshes while the resorbable mesh was characterized by a collagen deposition more similar to native connective tissue and an increased thickness of the integrating tissue. The control polypropylene mesh provoked a typical chronic inflammation persistent over the 36-month study period. As the resorbable test mesh gradually degraded it was replaced by a newly formed collagen matrix with an increasing ratio of collagen type I/III, indicating a continuous remodeling of the collagen towards a strong connective tissue. After 36 months, the test mesh was fully resorbed and only microscopic implant residues could be found in the tissue.ConclusionsThis study suggests that the concept of a long-term resorbable mesh with time-dependent mechanical characteristics offers new possibilities for soft tissue repair and reinforcement.

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Tissue Healing during Degradation of a Long-Lasting Bioresorbable γ-Ray-Sterilised Poly(Lactic Acid) Mesh in the Rat: A 12-Month Study

Cited by 11 publications

References 42 publications

A preclinical evaluation of polypropylene/polylacticacid hybrid meshes for fascial defect repair using a rat abdominal hernia model

A preclinical evaluation of polypropylene/polylacticacid hybrid meshes for fascial defect repair using a rat abdominal hernia model

In vivo response to polypropylene following implantation in animal models: a review of biocompatibility

Three-year results from a preclinical implantation study of a long-term resorbable surgical mesh with time-dependent mechanical characteristics

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