Tissue Ingrowth Into Perforated Polymethylmethacrylate Orbital Implants

Miyashita, Denise; Chahud, Fernando; Silva, Gyl Eanes Barros da; Albuquerque, Verônica Batista de; Garcia, Denny M.; Cruz, Antônio Augusto Velasco e

doi:10.1097/iop.0b013e318285b4c8

Cited by 12 publications

(13 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The design (number of channels and their large diameter) facilitated the fixation of the PIIC to the orbital fascia and allowed ingrowth of fibrovascular tissue, as demonstrated both histopathologically and ultrasonographically (Figs and ). These findings are in agreement with previous studies using PIICs following enucleation in rabbits and rats where ingrowth of fibrovascular tissue into the channels was demonstrated. In our study, we were able to image blood flow in newly formed blood vessels in the channels within 30 days after surgery.…”

Section: Discussionsupporting

confidence: 93%

“…Our results show that PIICs can be safely implanted following enucleation in dogs and cats and result in a long‐term esthetic presentation. Channels could easily be drilled into the PIIC, as PMMA is a strong and sturdy material . The design (number of channels and their large diameter) facilitated the fixation of the PIIC to the orbital fascia and allowed ingrowth of fibrovascular tissue, as demonstrated both histopathologically and ultrasonographically (Figs and ).…”

Section: Discussionmentioning

confidence: 99%

“…Orbital implants are frequently used to fill anophthalmic orbits following enucleation or exenteration, as they serve to fill the resulting dead space and prevent postoperative concavity of the skin …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polymethylmethacrylate orbital implants with interconnecting channels. A retrospective study following enucleation in dogs and cats

Oriá

Souza

Neto

et al. 2015

Veterinary Ophthalmology

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Polymethylmethacrylate orbital implants with interconnecting channels. A retrospective study following enucleation in dogs and cats

Oriá

Souza

Neto

et al. 2015

Veterinary Ophthalmology

View full text Add to dashboard Cite

show abstract

“…With the exception of the conical synthetic hydroxyapatite implants (Kundu et al, 2005), which were perforated to permit the suturing of the extra-ocular muscles, there are no references in the literature on the use of implants in the form of spheres in the orbital cavity provided with large channels for interconnection, with the objective of permitting the infiltration of fibrovascular tissue, with exception of the recent study using perforated acrylic orbital implants in eviscerated rabbits (Miyashita et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Double-setting alpha-tricalcium phosphate cement provided with interconection channels in rabbits after enucleation: A potential implant for the anophthalmic socket

Gomes

Oriá

Neto

et al. 2015

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

The purpose of this study was to evaluate the macroscopy and microstructure of a double setting alphatricalcium phosphate bone cement sphere provided with interconnection channels (alpha-TCP-i), as well as the integration of the implant with the rabbits' orbital tissue, through macroscopic analysis and histopathology. The external and internal surfaces of the alpha-TCP-i were evaluated macroscopically and by electron microscopy. Twelve New Zealand rabbits received 12mm implants of alpha-TCP-i following enucleation of the left eye. The clinical assessment was undertaken daily during the first 15 days, followed by fortnightly assessment until the end of the study period. For the morphological analysis, exenteration was performed in 3 animals per experimental period (15, 45, 90 and 180 days). The external and internal surfaces of the implant appeared solid, smooth and compact, with six channels which interconnected centrally. The micro-architecture was characterized by the formation of columns of hexagonal crystals. No signs of infection, exposure, dehiscence of sutures or extrusion of the implant were noted in any of the animals during the entire period of the study. The morphological evaluation demonstrated the presence of a thin capsule around the implant, from whence appeared fibro-vascular projections, which penetrated it through the interconnecting channels. In the first days after the insertion of the implant, an intense inflammatory reaction was noted. At 180 days, however, there were no signs of inflammation. The alpha-tricalcium phosphate cement implant was well tolerated in this rabbit model and appeared to be relatively inert with some fibrovascular ingrowth through the large channels.Keywords: implant, eye, prosthesis RESUMO Avaliaram-se a macroscopia e a microestrutura de esferas compostas por cimento ósseo de alfa-fosfato tricálcico de dupla pega munido de canais de interconexão (alfa-TCP-i) e a integração do implante ao tecido orbital de coelhos através de análise macroscópica e histopatológica. A superfície interna e externa do alfa-TCP-i foi avaliada macroscopicamente e por microscopia eletrônica. Após enucleação do bulbo ocular esquerdo, 12 coelhos da raça Nova Zelândia receberam implantes do alfa-TCP-i com 12mm de diâmetro. A avaliação clínica foi realizada diariamente nos primeiros 15 dias e depois a cada quinze dias até o fim do período de estudo. Para análise morfológica, seguiu-se a exenteração de três animais por período experimental (15, 45, 90 e 180 dias). As superfícies externa e interna do implante mostraram-se compactas

show abstract

“…Contudo, dentre os materiais não integráveis, o PMMA foi o que apresentou extrusão, como complicação, mais tardiamente [22]. Outros autores relataram que são muito raros os efeitos adversos causados pelo PMMA [11,19,24]. É importante salientar também que, neste animal, após nove meses da introdução do implante de PMMA, não foi observada depressão local, contradizendo as observações feitas num estudo na espécie equina, cujo relato foi de atrofia do tecido orbital em volta da prótese e consequente depressão e perda da estética [1].…”

Section: Discussionunclassified

Use of Acrylic Resin to Fill the Orbital Cavity after Exenteration in a Dog with Conjunctival Hemangiosarcoma

Teixeira

Buquera

Lucena

et al. 2019

Acta Scientiae. Vet.

View full text Add to dashboard Cite

Background: The hemangiossarcoma (HSA) is a malignant tumor originated from the alterations of vascular endothelial cells. As it has an aggressive behavior, it is indicated, as initial treatment, wide surgical excision, such as the exenteration, which results in the surgical removal of the ocular bulb and adjacent tissues. The referred technique has as a result a concave orbit and aesthetically unacceptable. Therefore, various materials, used as orbital implants, have been studied and used in several species. Thus, it was aimed to report the use of the polymethylmethacrylate (PMMA) to fill the orbital cavity after exenteration in a dog with conjunctival HSA.Case: A 10-year-old male Pitbull dog was assisted, with a clinical history of growth of a reddish tissue in the left eye, causing constant hemorrhage, with an evolution of two months. At ophthalmic examination of the left eye, in the temporal bulbar conjunctive was found a reddish neoformation, with an irregular surface, measuring approximately 4x2x2 cm. The biopsy and aspiration cytology of the neoformation, revealed cells that inferred that they were those of conjunctival HSA. The hemogram revealed normocytic anemia; the biochemical profile was with the standards of normality and no metastasis were found in the ultrasonography and X-ray. The treatment of choice was the exenteration. Initially, the palpebral borders were approximated using continuous simple suture wit monofilament nylon thread. An incision was made in the skin, along the orbital rim and then was performed a rhombus dissection of the conjunctive and all the extraocular muscles. Next, the eye globe, together with the neoplasia, soft tissues of the orbital cavity and third eyelid were removed. The PMMA was obtained from a mixture of the powder (polymer) and of the liquid (monomer) in the ratio of 1:1 in a sterile recipient, in order to obtain a liquid suspension. Still in its paste-like form, the PMMA was molded in the orbit itself without going beyond its limits, filling in. At the moment of the polymerization of the PMMA, the site was irrigated with cold sterile saline solution for the reduction of the temperature caused by the thermal reaction. For the closing of the conjunctive, a continuous simple suture was performed, using 910 4-0 polyglactin thread and, in the suture of the skin, simple interrupted stiches were used with 3-0 monofilament nylon thread. After the surgery, tramadol hydrochloride was administered at a dose of 2 mg/kg/SC and meloxicam at a dose of 0.1 mg/kg/SC. In the post-operative phase, the animal was treated with ampicillin suspension at a dose of 20 mg/kg/TID/PO during 10 days; metronidazole at a dose of 15 mg/kg /BID/PO during 10 days and the application of 0.5% chloramphenicol ocular ointment, 10.000UI of retinyl acetate and 2.5% amino acids on the stiches, SID, until their removal. After nine months, the owner reported a satisfactory result in relation to the aesthetic aspect, denying the presence of any ocular alterations or discomfort of the animal.Discussion: The use of the PMMA implant proved to be an excellent alternative to fill the anophthalmic cavity after exenteration in a dog with conjunctival HSA, seen as it provided, most importantly, the maintenance of the orbital volume, granting an adequate aesthetic aspect, already established among some authors, without the presence of secretion, inflammation and local infection. It is worth emphasizing that, despite the patient in question having been treat with a broad-spectrum antibiotic after the surgery, in other reports, the absence of local infection was associated to the high temperature that the PMMA reaches during the exothermic reaction in the polymerization stage. Furthermore, the referred implant is cost-effective, offers easy molding to the orbit and absence of extrusion. In light of this, it is therefore suggested that the referred implant is a pertinent alternative for use in similar cases.

show abstract

Tissue Ingrowth Into Perforated Polymethylmethacrylate Orbital Implants

Abstract: Similar to porous implants, perforated acrylic implants permit fibrovascular ingrowth from surrounding orbital tissues.

Cited by 12 publications

References 15 publications

Polymethylmethacrylate orbital implants with interconnecting channels. A retrospective study following enucleation in dogs and cats

Polymethylmethacrylate orbital implants with interconnecting channels. A retrospective study following enucleation in dogs and cats

Double-setting alpha-tricalcium phosphate cement provided with interconection channels in rabbits after enucleation: A potential implant for the anophthalmic socket

Use of Acrylic Resin to Fill the Orbital Cavity after Exenteration in a Dog with Conjunctival Hemangiosarcoma

Contact Info

Product

Resources

About