Tissue mast cells in health and disease

Parwaresch, M. R.; Homy, H.-P.; Lennert, K.

doi:10.1016/s0344-0338(85)80184-9

Cited by 185 publications

(102 citation statements)

References 34 publications

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“…20 -22 SM is a clonal hematological disease that almost invariably affects the BM. [1][2][3][4][11][12][13][14]24 In the present study, we show that the BM MVD is significantly higher in SM compared to CM/UP or controls. This observation is novel and is in line with the notion that SM is a neoplastic hematological disease.…”

Section: Discussionsupporting

confidence: 64%

“…[1][2][3][4] Cutaneous mastocytosis (CM) is commonly diagnosed in childhood and has a favorable prognosis. 5 In a high percentage of cases with pediatric CM, spontaneous regression is found.…”

mentioning

confidence: 99%

“…Systemic mastocytosis (SM) can develop at any age and is characterized by multiorgan involvement and disease persistence. [1][2][3][4] In most SM patients, somatic mutations in the kinase domain of c-kit are detectable. 6 -8 The majority of patients with SM show an indolent clinical course throughout decades.…”

mentioning

confidence: 99%

“…6 -8 The majority of patients with SM show an indolent clinical course throughout decades. [1][2][3][4] However, in a smaller subset, progression to aggressive or even leukemic disease is seen. 1-4,9 -12 These patients acquire organopathy caused by progressive MC infiltrates in diverse organs such as the bone marrow (BM), liver, or skeletal system.…”

mentioning

confidence: 99%

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Increased Angiogenesis in the Bone Marrow of Patients with Systemic Mastocytosis

Wimazal

Jordan

Sperr

et al. 2002

The American Journal of Pathology

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Recent data suggest that angiogenesis in the bone marrow (BM) is augmented and associated with growth of neoplastic cells in various hematological malignancies. Systemic mastocytosis (SM) is a neoplasm affecting multilineage and mast cell (MC)-committed hemopoietic progenitors. In the present study, we have assessed the BM microvessel density (MVD) by CD34 immunohistochemistry in 21 patients with SM, 5 with cutaneous mastocytosis (no BM infiltrates), and 5 control cases (normal BM). The median BM MVD was significantly higher in SM compared to cutaneous mastocytosis or controls (P < 0.05). In addition, a significant correlation (r ‫؍‬ 0.74) between the BM MVD and grade of MC infiltration (percent tryptase ؉ BM infiltrates) was found in SM. Moreover, the MVD was higher in MC infiltrates compared to the nonaffected adjacent marrow (P < 0.05). Immunohistochemical staining revealed expression of vascular endothelial growth factor in MC infiltrates. The notion that SM is associated with increased BM angiogenesis and vascular endothelial growth factor expression may have implications for the biology of disease and development of new treatment strategies.

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Section: Discussionsupporting

confidence: 64%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Increased Angiogenesis in the Bone Marrow of Patients with Systemic Mastocytosis

Wimazal

Jordan

Sperr

et al. 2002

The American Journal of Pathology

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“…Similarly an inverse correlation between tumour incidence and tissue histamine levels was reported for fibrosarcomas and Lewis lung carcinomas (Burtin et al, 1985). The importance of (Lewis & Austin, 1981;Parwaresch et al, 1985), but in direct contrast to the reports of a protective role against tumours some investigators have stressed an association between mast cells and rapid tumour growth (Csaba et al, 1961;Farnoush & McKenzie, 1983). Both heparin and histamine have been reported to have mitogenic properties (Roche, 1985;Norrby, 1985;Norrby & Enestrom, 1985) and Hartveit (1981) reported that mast cell degranulation in human breast carcinomas was associated with areas of infiltrative growth.…”

Section: Discussionmentioning

confidence: 99%

Mast cells and matrix degradation at sites of tumour invasion in rat mammary adenocarcinoma

Dabbous¹,

Walker²,

Haney³

et al. 1986

Br J Cancer

111

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Summary Significant numbers of mast cells have been demonstrated histologically around the periphery of the invasive rat mammary adenocarcinoma 13672NF. The number of mast cells at microfoci along the tumour:host tissue junction was significantly greater than that found in normal mammary tissues, and few mast cells were detected within the tumour itself. Mast cell degranulation, often associated with disruption and lysis of the connective tissue matrix, was a common feature in later stages of tumour proliferation. When soluble products derived from purified rat peritoneal mast cells were added to monolayer cultures of rat stromal fibroblasts or tumour cells they stimulated a significant increase in total collagenase production, and the mast cell products were also capable of activating the latent collagenases thus produced. Histological examination indicated that degradation of local collagenous matrix was a common feature of mast cell degranulation, an observation possibly explained by the release of mast cell enzymes and/or the potential of this cell to modulate the expression of collagenolytic activity by surrounding cells. These observations suggest that, at least in some tumours, mast cells contribute to the connective tissue breakdown commonly associated with tumour invasiveness and metastatic spread.

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Quantitative morphology of mast cells in skeletal muscle of normal and genetically dystrophic mice

1997

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Tissue mast cells in health and disease

Cited by 185 publications

References 34 publications

Increased Angiogenesis in the Bone Marrow of Patients with Systemic Mastocytosis

Increased Angiogenesis in the Bone Marrow of Patients with Systemic Mastocytosis

Mast cells and matrix degradation at sites of tumour invasion in rat mammary adenocarcinoma

Quantitative morphology of mast cells in skeletal muscle of normal and genetically dystrophic mice

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