Tissue MMP-2/TIMP-2-complex are better prognostic factors than serum MMP-2, MMP-9 or TIMP-1 in Stage I–III lung carcinoma

Hoikkala, S.; Pääkkö, P; Soini, Ylermi; Mäkitaro, Riitta; Kinnula, VL; Turpeenniemi‐Hujanen, Taina

doi:10.1016/j.canlet.2005.05.012

Cited by 48 publications

(30 citation statements)

References 17 publications

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“…Additional studies have investigated the function of circulating MMP-2 and MMP-9 in BC patients (51,52); the results revealed increased MMP-9 expression and activity in malignant tumors, and enhanced MMP-2 activity in malignant tumors exhibiting high estrogen receptor expression. These studies indicate that serum levels of MMP-2 or -9 may present useful markers for the staging and prognosis of BC and other types of cancer (53), such as prostate adenocarcinoma, in association with prostate-specific antigen levels, gastric cancer and lung carcinoma (54)(55)(56).…”

Section: Discussionmentioning

confidence: 92%

Physical exercise modulates the level of serum MMP-2 and MMP-9 in patients with breast cancer

et al. 2016

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Abstract. Matrix metalloproteinases (MMPs) exhibit an important function in extracellular matrix degradation. MMPs modulate the activation of growth factors, cytokines and metastasis. At present, the effect of exercise on serum levels of MMP-2 and -9 remains unclear. The aim of the present study was to investigate the effect of various physical activities on the circulating levels of MMP-2 and -9 in breast cancer (BC) survivors and healthy subjects. A total of 66 female subjects were enrolled in the present study. The cohort included 46 BC survivors and 20 healthy subjects divided into 5 groups: Group A (17 BC survivors, participating in recreational dragon boat paddling), group B (14 BC survivors, participating in recreational physical activity), group C (15 sedentary BC survivors), group D (10 healthy subjects, participating in recreational physical activity) and group E (10 sedentary healthy subjects). ELISA assays revealed a significant increase in the level of circulating MMP-2 in group B compared with all other groups. Recreational physical activity increased the levels of MMP-9 in healthy subjects (group D vs. E), however, the differences were not statistically significant, while in the BC survivor groups the results were opposite, with exercise reducing MMP-9 levels (group B vs. C). Furthermore, a significant increase in MMP-2 was observed in group B lymph node metastasis-positive (N+) subjects compared with group A and C N+ subjects. Thus, the results of the present study indicate that various physical activities modulate the levels of circulating MMP-2 and -9 in BC survivors, and the same exercise program induces a different effect when undertaken by healthy subjects and BC survivors. These results may have important implications with regard to the selection of appropriate physical activities for BC survivors, leading to improvements to their survival and prevention of recurrence, as well as amelioration of physical function, quality of life and fatigue.

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Section: Discussionmentioning

confidence: 92%

Physical exercise modulates the level of serum MMP-2 and MMP-9 in patients with breast cancer

et al. 2016

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“…We tested the diagnostic performances of serum and plasma MMP-9 in gastric cancer patients and confirmed that plasma MMP-9 is a better diagnostic marker than serum MMP-9, at least in gastric cancer. This may partly explain why studies measuring serum MMP-9 tend to report nonsignificant results (10,25,34,35), whereas those using plasma samples present more promising data (9,13,15,36,37).…”

Section: Discussionmentioning

confidence: 99%

Plasma Matrix Metalloproteinase-9 Level Is Better than Serum Matrix Metalloproteinase-9 Level to Predict Gastric Cancer Evolution

Chiang

et al. 2007

Clinical Cancer Research

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Purpose: Matrix metalloproteinase-9 (MMP-9) in blood is a promising new tumor marker.The aims of the present study are to compare the usefulness of plasma and serum MMP-9 levels for predicting gastric cancer development, invasion, and survival. Experimental Design: In this nested case-control study, 114 gastric cancer patients and 87 healthy controls were enrolled. MMP-9 levels and activities were quantitatively measured by ELISA assay and zymography. The results were compared with the occurrence, clinicopathologic features, and outcomes of gastric cancer patients. The follow-up time for all patients was at least 5 years. Results: Serum MMP-9 levels were significantly higher than plasma MMP-9 levels. Both plasma and serum MMP-9 levels correlated significantly with active MMP-9 identified by zymography (P = 0.002 and P = 0.048, respectively). Plasma MMP-9 level was significantly elevated in gastric cancer patients when compared with control subjects (P < 0.001). Serum MMP-9 levels did not differ between the groups. Receiver-operator characteristics analysis showed the values of sensitivity (82.5%) and specificity (65.5%) at the maximum accuracy for plasma MMP-9 at z60 ng/mL (P < 0.001). Elevated plasma MMP-9 correlated significantly with lymph node metastasis [odds ratio (OR), 3.43; P = 0.019], lymphatic invasion (OR, 7.58; P = 0.009), and venous invasion (OR, 4.14; P = 0.033). Patients with elevated plasma MMP-9 levels had poorer survival rates than those with normal plasma MMP-9 levels (P = 0.038). Serum MMP-9 level did not correlate well with gastric cancer^invasive phenotypes or survival. Conclusion: Our results suggest plasma MMP-9 level is a better marker than serum MMP-9 level for predicting gastric cancer development and progression.

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“…48,49 While it is true that the presence of lung cancer in some of our patients may have influenced the results, we tried to avoid this bias by collecting lung tissue from areas not affected by tumor and by having included subjects with lung cancer in the control groups. Furthermore, since the highest MMP-2 expression was observed in the group without concomitant cancer (ie, smokers with severe COPD undergoing lung volume reduction surgery), we feel rather confident that our findings of an increased MMP-2 expression in COPD patients are valid.…”

Section: Mmp-2mentioning

confidence: 99%

Matrix Metalloproteinase-2 Protein in Lung Periphery Is Related to COPD Progression

Baraldo

Bazzan

Zanin

et al. 2007

Chest

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Tissue MMP-2/TIMP-2-complex are better prognostic factors than serum MMP-2, MMP-9 or TIMP-1 in Stage I–III lung carcinoma

Cited by 48 publications

References 17 publications

Physical exercise modulates the level of serum MMP-2 and MMP-9 in patients with breast cancer

Physical exercise modulates the level of serum MMP-2 and MMP-9 in patients with breast cancer

Plasma Matrix Metalloproteinase-9 Level Is Better than Serum Matrix Metalloproteinase-9 Level to Predict Gastric Cancer Evolution

Matrix Metalloproteinase-2 Protein in Lung Periphery Is Related to COPD Progression

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