Tissue polypeptide antigen &amp; interleukin-6: Are their serum levels a predictor for response to chemotherapy in breast cancer?

Al-Youzbaki, Wahda B.; Al-Youzbaki, Niaam Basheer; Telfah, Muwaffaq Mezeil

doi:10.12669/pjms.305.5199

Cited by 5 publications

(7 citation statements)

References 18 publications

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“…IL-6 is secreted by various cell types, including breast cancer cells. The response to IL-6 in such cells depends on the expression of ERs (24). The ER-positive MCF-7 cell line does not secrete IL-6, whereas ER-negative MD-MBA-231 cells do (32,33).…”

Section: Discussionmentioning

confidence: 99%

“…However, the association between CRP and the prognosis of patients with breast cancer remains controversial (18)(19)(20). The association between serum IL-6 expression levels and breast cancer has been reported in treatment prognosis (21)(22)(23) and resistance to chemotherapy (24), and other studies have reported an association between serum IL-6, CRP and breast cancer (25,26). Although previous studies (21-23) have investigated the association between IL-6 and prognosis in patients with metastasis, the prognostic impact of preoperative IL-6 levels remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic impact of interleukin‑6 and C‑reactive protein on patients with breast cancer

et al. 2019

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The prognostic impacts of preoperative C-reactive protein (CRP) and interleukin (IL)-6 expression levels in patients with breast cancer remain controversial. A total of 55 female patients with invasive breast cancer were enrolled, and preoperative prognostic parameters including IL-6 and CRP were analyzed. Overall survival (OS) and recurrence-free survival (RFS) were estimated using the Kaplan-Meier method, and candidates' prognostic factors were examined using a Cox proportional hazard model. Using receiver operating characteristic curve analysis, IL-6 at 10.0 pg/ml and CRP at 0.12 mg/dl were determined as threshold values to predict OS and RFS, respectively. Patients with IL-6 ≥10.0 pg/ml had poorer OS compared with those with IL-6 <10.0 pg/ml (P=0.003), and patients with CRP ≥0.12 mg/dl had poorer RFS compared with those with CRP <0.12 mg/dl (P<0.001). Serum IL-6 level (hazard ratio, 13.230; 95% confidence interval, 1.285-136.214; P=0.030) and triple-negative subtype (hazard ratio, 11.739; 95% confidence interval, 1.415-97.362; P=0.023) were independent prognostic factors for OS, and CRP expression level was an independent prognostic factor for RFS in patients with breast cancer (hazard ratio, 18.571; 95% confidence interval, 2.240-153.949; P=0.007). In patients with invasive breast cancer, preoperative serum IL-6 and triple-negative subtype may be independent prognostic factors for OS, while for RFS, preoperative CRP may be a more accurate prognostic factor compared with those currently established.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prognostic impact of interleukin‑6 and C‑reactive protein on patients with breast cancer

et al. 2019

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“…Historically speaking, Albahlul is a religious person who lived in the Abbasid era, and was known for his ability to get rid of the complicated situations. (12) The story teller is in line with the Muslim merchant`s point of view. He describes him as the one who deserves our sympathy and support.…”

mentioning

confidence: 85%

“…Otherwise, they had nothing but unrest. (18) This feeling of unrest can even be attributed to the economic state the Jewish people faced at that time. Economy is the backbone of the Jewish life and character.…”

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confidence: 99%

The Jews and the Muslims: A Study in the Similarity between “The Merchant of Venice” and an Islamic Story entitled “The Merchant and the Jew”

Nayel¹

2019

IJELS

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Cross cultural studies have attracted the attention of researchers for a long period of time. Literary works often reflect the culture, ideas and thoughts of their societies. The story of the "the Merchant and the Jew''appeared in a number of books; one of which is "AL-Bahlul Stories''. It has a great resemblance to the play "The Merchant of Venice'' written by Shakespeare. The two stories have thematic similarity as they both deal with the relation between a non-Jewish merchant and a Jewish merchant. In this paper, we are trying to trace the similarities, and the differences between the two works. " The Merchant and the Jew'' is the same as the story we find in the play, which is mainly concerned with the relationship between Antonio, the Christian merchant and Shylock, the Jewish one. The similarity is also indicated in terms of the idea of usury which is clearly available in the two works, and in Shakespeare`s play, it has a striking similarity to one of Islamic hadiths in which usury is highly condemned. As for the differences, the character of the Christian merchant in the play is not available in the story of "The Merchant and the Jew", but we have a Muslim merchant instead. Another difference is the place of the action which is Venice in the play but Baghdad in the story.

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“…In autoimmune disease, IL-6 related abnormal presentation of hepcidin is central to anemia of chronic diseases including RA and SLE. Signifi cant elevation of serum IL-6 is found in breast cancer patients when compared with healthy controls [55,56]. Breast cancer cells may secrete IL-6 to support the proliferation of cancer, and reduction of proliferation of cancer is observed after IL-6 knockdown [57].…”

Section: The Rationale Of Developing Anti-il-6 For the Clinical Theramentioning

confidence: 99%

The Biological Effects of Interleukin-6 and Their Clinical Applications in Autoimmune Diseases and Cancers

Yang¹

2017

Rheumatica Acta: Open Access

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Interleukin-6 (IL-6) is one of the pro-infl ammatory cytokines involved in pathogenesis of various autoimmune and chronic infl ammatory diseases. IL-6 through binding to its cellular receptor can transduce both classical-and trans-signaling pathways. Overproduction of circulating IL-6 can be detected in patients with different autoimmune diseases. Tocilizumab, a humanized monoclonal antibody against IL-6 receptor, can block IL-6-mediated signaling and has been approved for the treatment of rheumatoid arthritis and Castleman's disease. Besides, expression of IL-6 may promote tumorigenesis and has been detected in various tumors, including multiple myeloma, colorectal cancer, breast cancer, lymphoma, breast cancer and lung cancer. Furthermore, increased levels of circulating IL-6 are associated with poor prognosis and cachexia in cancer patients. Monotherapy with IL-6 blockade or a combination therapy with both IL-6 blockade and conventional chemotherapy may reduce the progression of cancer and improve the status of cachexia in cancer patients. Finally, based upon the known biological effects of IL-6, diseases, other than autoimmune diseases and cancers, potentially to be anti-IL-6 candidates will be briefl y discussed.

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Tissue polypeptide antigen & interleukin-6: Are their serum levels a predictor for response to chemotherapy in breast cancer?

Cited by 5 publications

References 18 publications

Prognostic impact of interleukin‑6 and C‑reactive protein on patients with breast cancer

Prognostic impact of interleukin‑6 and C‑reactive protein on patients with breast cancer

The Jews and the Muslims: A Study in the Similarity between “The Merchant of Venice” and an Islamic Story entitled “The Merchant and the Jew”

The Biological Effects of Interleukin-6 and Their Clinical Applications in Autoimmune Diseases and Cancers

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