Tissue-specific oxidative stress responses in fish exposed to 2,4-D and azinphosmethyl

Oruç, Elif Özcan; Sevgiler, Yusuf; Üner, Nevin

doi:10.1016/j.cca.2003.11.006

Cited by 137 publications

(29 citation statements)

References 35 publications

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“…These differences in antioxidant profiles are probably related to their anatomic position determining the uptake, distribution and bioaccumulation of pollutants (Ahmad et al 2006), as well as their different rates of ROS generation and different antioxidant potentials (Monteiro et al 2006). Some studies also report tissue-specific oxidative stress responses and antioxidants in fish exposed to environmental contaminants (Oruç et al 2004;Ahmad et al 2006;Monteiro et al 2009). …”

Section: Discussionmentioning

confidence: 92%

Inorganic mercury exposure: toxicological effects, oxidative stress biomarkers and bioaccumulation in the tropical freshwater fish matrinxã, Brycon amazonicus (Spix and Agassiz, 1829)

2009

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Alterations in the antioxidant cellular system have often been proposed as biomarkers of pollutant-mediated toxicity. This study evaluated the effects of mercury on oxidative stress biomarkers and bioaccumulation in the liver, gills, white muscle and heart of the freshwater fish matrinxã, Brycon amazonicus, exposed to a nominal and sub-lethal concentration (~20% of 96 h-LC(50)) of 0.15 mg L(-1) of mercury chloride (HgCl(2)) for 96 h in a static system. Increases in superoxide dismutase, catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST) and glutathione reductase (GR) were observed in all tissues after HgCl(2) exposure, except for white muscle GR activity and hepatic GPx. In the liver and gills, the exposure to HgCl(2) also induced significant increases in reduced glutathione (GSH). Conversely, exposure to HgCl(2) caused a significant decrease in the GSH levels and an increase in the oxidized glutathione (GSSG) content in the white muscle, while both GSH and GSSG levels increased significantly in the heart muscle. Metallothionein concentrations were significantly high after HgCl(2) exposure in the liver, gills and heart, but remained at control values in the white muscle. HgCl(2) exposure induced oxidative damage, increasing the lipid peroxidation and protein carbonyl content in all tissues. Mercury accumulated significantly in all the fish tissue. The pattern of accumulation follows the order gills > liver >> heart > white muscle. In conclusion, these data suggest that oxidative stress in response to inorganic mercury exposure could be the main pathway of toxicity induced by this metal in fish.

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Section: Discussionmentioning

confidence: 92%

Inorganic mercury exposure: toxicological effects, oxidative stress biomarkers and bioaccumulation in the tropical freshwater fish matrinxã, Brycon amazonicus (Spix and Agassiz, 1829)

2009

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“…Similar results were also observed in other studies. GST enzyme activity was induced by the exposure of OP azinphos-methyl in the liver of O. niloticus and C. carpio, while no change was observed in brain and gill tissues (Ozcan Oruc et al, 2004). The (N = 5).…”

Section: Discussionmentioning

confidence: 99%

Tissue-specific effects of fenthion on glutathione metabolism modulated by NAC and BSO inOreochromis niloticus

Sevgiler¹,

Üner

2010

Drug and Chemical Toxicology

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“…In addition, Norway rats are more resistant to DZN toxicity, which can due to continuous contact with poisonous material in environment. The response of antioxidant system to oxidative stress shows differences from one strain to another due to DZN detoxification capacity and the differences in antioxidant potential [9,37].…”

Section: Discussionmentioning

confidence: 99%

“…Handy et al [8] observed pathological changes in spleen, thymus and blood cells following oral administration of 300 mg/kg DZN to mice. Tissue differences in the oxidative stress responses and antioxidants are also reported in various fish species [9].…”

Section: Introductionmentioning

confidence: 98%

Strain-Related Differences on Response of Liver and Kidney Antioxidant Defense System in Two Rat Strains Following Diazinon Exposure

Salehi

Jafari

Asgari

et al. 2016

Zahedan J Res Med Sci

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Background: Diazinon (DZN) is one of the most organophosphates that widely used in agriculture and ectoparasiticide formulations. Its extensive use as an effective pesticide was associated with the environmental deleterious effects on biological systems. Objectives: The aim of this study was to investigate the potency of DZN to affect serum biochemical parameters and the antioxidant defense system in the liver and kidney of two rat strains. Materials and Methods:In this experimental study, 30 female Wistar and 30 female Norway rats were randomly divided into control and DZN groups. DZN group was divided into four subgroups: 25, 50, 100 and 200 mg/kg of DZN administered groups by i.p. injection. The parameters were evaluated after 24 hours. Results: At higher doses of DZN, superoxide dismutase, catalase, glutathione S-transferase and lactate dehydrogenase activities and glutathione (GSH) and malondialdehyde levels in liver and kidney of Wistar rats were higher than Norway rats. At these concentrations, DZN increased some serum biochemical indices such as liver enzymes activities and levels of urea, uric acid and creatinine in Wistar rat. Conclusions: DZN at higher doses alters the oxidant-antioxidant balance in liver and kidney of both rat strains and induces oxidative stress, which is associated with a depletion of GSH and increased lipid peroxidation. However, Wistar rats are found to be more sensitive to the toxicity of DZN compared to Norway rats. In addition, the effect of DZN on liver antioxidant system was more than kidney.

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Tissue-specific oxidative stress responses in fish exposed to 2,4-D and azinphosmethyl

Cited by 137 publications

References 35 publications

Inorganic mercury exposure: toxicological effects, oxidative stress biomarkers and bioaccumulation in the tropical freshwater fish matrinxã, Brycon amazonicus (Spix and Agassiz, 1829)

Inorganic mercury exposure: toxicological effects, oxidative stress biomarkers and bioaccumulation in the tropical freshwater fish matrinxã, Brycon amazonicus (Spix and Agassiz, 1829)

Tissue-specific effects of fenthion on glutathione metabolism modulated by NAC and BSO inOreochromis niloticus

Strain-Related Differences on Response of Liver and Kidney Antioxidant Defense System in Two Rat Strains Following Diazinon Exposure

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