Tissue-specific parameters for the design of ECM-mimetic biomaterials

Tonti, Olivia R.; Larson, Hannah; Lipp, Sarah N.; Luetkemeyer, Callan M.; Makam, Megan; Vargas, Diego A.; Wilcox, Sean M.; Calve, Sarah

doi:10.1016/j.actbio.2021.04.017

Cited by 45 publications

(52 citation statements)

References 298 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For details on tissue‐specific biomaterial factors beyond porosity that are important for ECM‐mimetic scaffolds, the reader is directed to an excellent review by Tonti, et al. [ 195 ]…”

Section: Tissue‐specific Applications Of Porous Biomaterialsmentioning

confidence: 99%

“…Table 4 summarizes these tissue-specific host responses and functional impacts toward porous materials and Figure 4 shows some example surfaces relevant to the various tissues discussed. For details on tissue-specific biomaterial factors beyond porosity that are important for ECM-mimetic scaffolds, the reader is directed to an excellent review by Tonti, et al [195]…”

Section: Tissue-specific Applications Of Porous Biomaterialsmentioning

confidence: 99%

See 1 more Smart Citation

Medical Applications of Porous Biomaterials: Features of Porosity and Tissue‐Specific Implications for Biocompatibility

Hernandez

Woodrow

2022

Adv Healthcare Materials

View full text Add to dashboard Cite

Porosity is an important material feature commonly employed in implants and tissue scaffolds. The presence of material voids permits the infiltration of cells, mechanical compliance, and outward diffusion of pharmaceutical agents. Various studies have confirmed that porosity indeed promotes favorable tissue responses, including minimal fibrous encapsulation during the foreign body reaction (FBR). However, increased biofilm formation and calcification is also described to arise due to biomaterial porosity. Additionally, the relevance of host responses like the FBR, infection, calcification, and thrombosis are dependent on tissue location and specific tissue microenvironment. In this review, the features of porous materials and the implications of porosity in the context of medical devices is discussed. Common methods to create porous materials are also discussed, as well as the parameters that are used to tune pore features. Responses toward porous biomaterials are also reviewed, including the various stages of the FBR, hemocompatibility, biofilm formation, and calcification. Finally, these host responses are considered in tissue specific locations including the subcutis, bone, cardiovascular system, brain, eye, and female reproductive tract. The effects of porosity across the various tissues of the body is highlighted and the need to consider the tissue context when engineering biomaterials is emphasized.

show abstract

“…For details on tissue‐specific biomaterial factors beyond porosity that are important for ECM‐mimetic scaffolds, the reader is directed to an excellent review by Tonti, et al. [ 195 ]…”

Section: Tissue‐specific Applications Of Porous Biomaterialsmentioning

confidence: 99%

Section: Tissue-specific Applications Of Porous Biomaterialsmentioning

confidence: 99%

Medical Applications of Porous Biomaterials: Features of Porosity and Tissue‐Specific Implications for Biocompatibility

Hernandez

Woodrow

2022

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Moreover, complete control of spatiotemporal presentation of such cues to mimic highly regenerative biological processes, such as development, is difficult [ 504 ]. However, control of dynamic reciprocity between cell and matrix may sidestep these drawbacks and lead to more biomimetic, instructive local niches for better biological responses to percutaneous devices [ 505 , 506 ] Degradability, stress relaxation, stiffness, morphology, etc. are potential routes of achieving control of pericellular matrix features, such as structure and/or contents [ [507] , [508] , [509] ].…”

Section: Future Perspectives and Avenues For Innovation And Inspirati...mentioning

confidence: 99%

Junctional epithelium and hemidesmosomes: Tape and rivets for solving the “percutaneous device dilemma” in dental and other permanent implants

Fischer

Aparicio

2022

Bioactive Materials

View full text Add to dashboard Cite

“…Another example of alignment is the skeletal muscle, where cells form long polynucleated units and are all elongated along the same axis. 5 , 256 , 307 …”

Section: Tissue-electronics Bio-interfacesmentioning

confidence: 99%

“…The mechanical properties of a cell niche can vary between tissues, ranging from 0.1 kPa of soft brain tissue to 430 KPa of calcified bone. 5 , 250 Importantly, the ideal ECM mechanical properties for a given cellular behavior have been shown to correlate with the elastic Young’s modulus ( E ) of the relevant living tissue. 24 This cell-type-specific responsiveness may indeed have important clinical implications, as the elasticity of a 3D scaffold can be effectively adjusted in order to specifically guide cells as they mature and assemble into a certain tissue.…”

Section: Tissue-electronics Bio-interfacesmentioning

confidence: 99%

Advances in Cell-Conductive Polymer Biointerfaces and Role of the Plasma Membrane

et al. 2021

View full text Add to dashboard Cite

The plasma membrane (PM) is often described as a wall, a physical barrier separating the cell cytoplasm from the extracellular matrix (ECM). Yet, this wall is a highly dynamic structure that can stretch, bend, and bud, allowing cells to respond and adapt to their surrounding environment. Inspired by shapes and geometries found in the biological world and exploiting the intrinsic properties of conductive polymers (CPs), several biomimetic strategies based on substrate dimensionality have been tailored in order to optimize the cell–chip coupling. Furthermore, device biofunctionalization through the use of ECM proteins or lipid bilayers have proven successful approaches to further maximize interfacial interactions. As the bio-electronic field aims at narrowing the gap between the electronic and the biological world, the possibility of effectively disguising conductive materials to “trick” cells to recognize artificial devices as part of their biological environment is a promising approach on the road to the seamless platform integration with cells.

show abstract

Tissue-specific parameters for the design of ECM-mimetic biomaterials

Cited by 45 publications

References 298 publications

Medical Applications of Porous Biomaterials: Features of Porosity and Tissue‐Specific Implications for Biocompatibility

Medical Applications of Porous Biomaterials: Features of Porosity and Tissue‐Specific Implications for Biocompatibility

Junctional epithelium and hemidesmosomes: Tape and rivets for solving the “percutaneous device dilemma” in dental and other permanent implants

Advances in Cell-Conductive Polymer Biointerfaces and Role of the Plasma Membrane

Contact Info

Product

Resources

About