Tissue Yields for Epidermal Growth Factor Receptor Analysis in Non-Small Cell Lung Cancer Patients in Trinidad and Tobago

Haralsingh, Aaron; West, Mark

doi:10.7759/cureus.12531

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…If the patient underwent a random cancer-unrelated CT scan or developed symptoms, he was assigned cancer patient status. The probability of random screening was set to 3.84% for the Greek population over 15 years old [ 1 , 2 , 3 ], as calculated from data shown in Supplementary Table S2 , and the probability of developing symptoms, by cancer type and stage, was set according to Supplementary Table S3 . If the patient was diagnosed with cancer, he/she was assumed to receive optimal treatment and was denoted as a “treated patient”.…”

Section: Methodsmentioning

confidence: 99%

“…Lung cancer is the first cause of cancer mortality, accounting for almost 1 in 5 deaths from cancer globally in both sexes, and responsible for ~270,000 deaths annually in Europe [ 1 ]. Most patients are diagnosed with advanced disease (>70%), while lung cancer is curable when diagnosed at initial stages and highly treatable in non-metastatic stages [ 2 ]. Lung cancer is etiologically associated with smoking and is a disease with a significant economic burden in societies [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Lung Cancer Screening in Greece: A Modelling Study to Estimate the Impact on Lung Cancer Life Years

Souliotis

Golna²,

Markakis³

et al. 2022

Cancers

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(1) Background: Lung cancer causes a substantial epidemiological burden in Greece. Yet, no formal national lung cancer screening program has been introduced to date. This study modeled the impact on lung cancer life years (LCLY) of a hypothetical scenario of comprehensive screening for lung cancer with low-dose computed tomography (LDCT) of the high-risk population in Greece, as defined by the US Preventive Services Taskforce, would be screened and linked to care (SLTC) for lung cancer versus the current scenario of background (opportunistic) screening only; (2) Methods: A stochastic model was built to monitor a hypothetical cohort of 100,000 high-risk men and women as they transitioned between health states (without cancer, with cancer, alive, dead) over 5 years. Transition probabilities were based on clinical expert opinion. Cancer cases, cancer-related deaths, and LCLYs lost were modeled in current and hypothetical scenarios. The difference in outcomes between the two scenarios was calculated. 150 iterations of simulation scenarios were conducted for 100,000 persons; (3) Results: Increasing SLTC to a hypothetical 100% of eligible high-risk people in Greece leads to a statistically significant reduction in deaths and in total years lost due to lung cancer, when compared with the current SLTC paradigm. Over 5 years, the model predicted a difference of 339 deaths and 944 lost years between the hypothetical and current scenario. More specifically, the hypothetical scenario led to fewer deaths (−24.56%, p < 0.001) and fewer life years lost (−31.01%, p < 0.001). It also led to a shift to lower-stage cancers at the time of diagnosis; (4) Conclusions: Our study suggests that applying a 100% screening strategy amongst high-risk adults aged 50–80, would result in additional averted deaths and LCLYs gained over 5 years in Greece.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lung Cancer Screening in Greece: A Modelling Study to Estimate the Impact on Lung Cancer Life Years

Souliotis

Golna²,

Markakis³

et al. 2022

Cancers

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“…(2)(3)(4) Unfortunately, this type of examination is still quite expensive and the facilities are not always available. Adequate samples must be obtained for this examination, (5) but sometimes these are difficult to obtain. Therefore, the prediction of EGFR mutation from clinical characteristics and imaging tests such as chest CT-scan is important.…”

Section: Introductionmentioning

confidence: 99%

Bone metastases tend to increase in non-small cell lung cancer with epidermal growth factor receptor mutation

et al. 2022

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BackgroundIncreased understanding in molecular pathology of advanced non-small cell lung cancer (NSCLC) over the past decades has led to personalized treatment approaches being advocated. Epidermal growth factor receptor (EGFR) mutation that often occurs in NSCLC can be identified using immunohistochemical examinations. Moreover, clarifying the relationship between computed tomography (CT) and EGFR mutation of NSCLC might inform therapeutic decision-making. The purpose of this study was to determine the relationship between metastatic sites on primary chest CT-scan and EGFR mutation in NSCLC lung cancer patients. MethodsAn cross-sectional design using secondary data was conducted, involving 76 NSCLC patients. EGFR mutations were determined by immunohistochemical examination and metastatic sites by chest CT-scan with contrast. The collected metastatic sites comprised hilar and mediastinal lymphadenopathy, pulmonary nodules, and bone, liver, spleen and suprarenal metastases. A Chi square test was used to analyze the data. ResultsThis study revealed that the highest NSCLC stage was IVb, found in 39 samples (51.3%), while 34 (44.7%) subjects had EGFR mutation. There was no statistically significant difference between metastatic site and positive EGFR mutation, although positive bone metastases (54.8%) tend to have more numerous positive EGFR mutations compared to negative bone metastases (37.7%) (p=0.142). ConclusionsPatients with positive bone metastases tend to have higher positive EGFR mutation compared to negative bone metastases in NSCLC lung cancer patients. Prospective studies evaluating patients with EGFR mutation for bone metastases should be considered. This can provide information on therapeutic decision-making to obtain good clinical outcomes.

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Tissue Yields for Epidermal Growth Factor Receptor Analysis in Non-Small Cell Lung Cancer Patients in Trinidad and Tobago

Cited by 2 publications

References 15 publications

Lung Cancer Screening in Greece: A Modelling Study to Estimate the Impact on Lung Cancer Life Years

Lung Cancer Screening in Greece: A Modelling Study to Estimate the Impact on Lung Cancer Life Years

Bone metastases tend to increase in non-small cell lung cancer with epidermal growth factor receptor mutation

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