2024
DOI: 10.1007/s11357-023-01045-4
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Titan mice as a model to test interventions that attenuate frailty and increase longevity

Benedikt Gille,
Annika Müller-Eigner,
Shari Gottschalk
et al.

Abstract: Wild-type murine models for aging research have lifespans of several years, which results in long experimental duration and late output. Here we explore the short-lived non-inbred Titan mouse as a mouse model to test longevity interventions. We show that Titan mice exhibit increased frailty and cellular senescence at an early age. Dietary intervention attenuates the frailty progression of Titan mice. Additionally, cyclic administration of the senolytic drug Navitoclax at early age increases the lifespan and re… Show more

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