Titanium alloy modified with anti-biofouling zwitterionic polymer to facilitate formation of bio-mineral layer

Nishida, Miku; Nakaji-Hirabayashi, Tadashi; Kitano, Hiromi; Saruwatari, Yoshiyuki; Matsuoka, Kazuyoshi

doi:10.1016/j.colsurfb.2017.01.018

Cited by 19 publications

(11 citation statements)

References 38 publications

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“…For the titanium alloys used in the blood contact biomaterials, the current surface modification technologies mainly include chemical treatment 7 (such as acid, alkali, H 2 O 2 treatments), surface biomolecules immobilization, 8 construction of polymer layer, 9 multifunctional surface modification, 10 surface bionics, 11 etc. However, these methods are still difficult to achieve real endothelial regeneration and completely inhibit the occurrence of coagulation.…”

Section: Introductionmentioning

confidence: 99%

Improved Blood Compatibility and Endothelialization of Titanium Oxide Nanotube Arrays on Titanium Surface by Zinc Doping

Pan

Gong

et al. 2020

ACS Biomater. Sci. Eng.

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Titanium dioxide nanotube arrays are widely used in biomaterials due to their unique tubular structure and tunable biocompatibility. In the present study, titanium oxide nanotube arrays with different diameters were prepared on the titanium surface by anodization, followed by zinc doping using hydrothermal treatment to enhance the biocompatibility. Both the nanotube dimensions and zinc doping had obvious influences on the hydrophilicity, protein adsorption, blood compatibility, and endothelial cell behaviors of the titanium surface. The increase of the diameter and zinc doping can improve the hydrophilicity of the titanium surface. The increase of nanotube diameter could reduce the albumin adsorption while increasing the fibrinogen adsorption. However, zinc doping can simultaneously promote the adsorption of albumin and fibrinogen, and the effect was more obvious for albumin. Zinc doping can significantly improve the blood compatibility of the titanium oxide nanotubes because it cannot only increase the activity of cyclophosphate guanylate (cGMP) but also significantly reduce the platelets adhesion and hemolysis rate. Moreover, it was also found that both the smaller diameter and zinc doping nanotubes can enhance the endothelial cell adhesion and proliferation as well as up-regulate the expression of NO and VEGF. Therefore, the zinc doped titanium dioxide nanotube array can be used to simultaneously improve the blood compatibility and promote endothelialization of the titanium-based biomaterials and implants, such as intravascular stents.

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Section: Introductionmentioning

confidence: 99%

Improved Blood Compatibility and Endothelialization of Titanium Oxide Nanotube Arrays on Titanium Surface by Zinc Doping

Pan

Gong

et al. 2020

ACS Biomater. Sci. Eng.

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“…Nishida et al attached a polymeric material composed of zwitterionic monomer carboxymethyl betaine (CMB) in combination with a vinyl monomer by the name of Phosmer PE™, vinylphosphonic acid, and 3‐methacyrloyloxypropyl trimethoxysilane on to titanium alloy substrates 113 . It was hypothesized that the polymeric material would be able to attach to the titanium alloy because it can bind to the metal oxides present on the substrate.…”

Section: Synthetic Polymer Coatingsmentioning

confidence: 99%

“…The cause of this was thought to be from the zwitterionic and HAp ions interacting; meaning, ammonium and carboxylate ions attracting PO 4 3− and Ca 2+. 113 …”

Section: Synthetic Polymer Coatingsmentioning

confidence: 99%

Surface modifications to enhance osseointegration–Resulting material properties and biological responses

2021

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As life expectancy and the age of the general population increases so does the need for improved implants. A major contributor to the failure of implants is poor osseointegration, which is typically described as the direct connection between bone and implant. This leads to unnecessary complications and an increased burden on the patient population. Modification of the implant surfaces through novel techniques, such as varying topography and/or applying coatings, has become a popular method to enhance the osseointegration capability of implants. Recent research has shown that particular surface features influence how bone cells interact with a material; however, it is unknown which exact features achieve optimal bone integration. In this review, current methods of modifying surfaces will be highlighted, and the resulting surface characteristics and biological responses are discussed. Review of the current strategies of surface modifications found that many coating types are more advantageous when used in combination; however, finding a surface modification that utilizes the mutual beneficial effects of important surface characteristics while still maintaining commercial viability is where future challenges exist.

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“…Other approaches using nonphosphate SAMs have been reported, showing results oriented to improve the osseointegration and reduce the bacterial adhesion [ 162 – 165 ].…”

Section: Nanostructured Sams: Trend For Dental Implantsmentioning

confidence: 99%

Self-Assembled Monolayers for Dental Implants

Freitas

Correa-Uribe

Martins

et al. 2018

International Journal of Dentistry

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Implant-based therapy is a mature approach to recover the health conditions of patients affected by edentulism. Thousands of dental implants are placed each year since their introduction in the 80s. However, implantology faces challenges that require more research strategies such as new support therapies for a world population with a continuous increase of life expectancy, to control periodontal status and new bioactive surfaces for implants. The present review is focused on self-assembled monolayers (SAMs) for dental implant materials as a nanoscale-processing approach to modify titanium surfaces. SAMs represent an easy, accurate, and precise approach to modify surface properties. These are stable, well-defined, and well-organized organic structures that allow to control the chemical properties of the interface at the molecular scale. The ability to control the composition and properties of SAMs precisely through synthesis (i.e., the synthetic chemistry of organic compounds with a wide range of functional groups is well established and in general very simple, being commercially available), combined with the simple methods to pattern their functional groups on complex geometry appliances, makes them a good system for fundamental studies regarding the interaction between surfaces, proteins, and cells, as well as to engineering surfaces in order to develop new biomaterials.

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Titanium alloy modified with anti-biofouling zwitterionic polymer to facilitate formation of bio-mineral layer

Cited by 19 publications

References 38 publications

Improved Blood Compatibility and Endothelialization of Titanium Oxide Nanotube Arrays on Titanium Surface by Zinc Doping

Improved Blood Compatibility and Endothelialization of Titanium Oxide Nanotube Arrays on Titanium Surface by Zinc Doping

Surface modifications to enhance osseointegration–Resulting material properties and biological responses

Self-Assembled Monolayers for Dental Implants

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