Titanium dioxide (rutile) particle uptake from the rat GI tract and translocation to systemic organs after oral administration

Jani, Praful U.; McCarthy, D.E.; Florence, Alexander T.

doi:10.1016/0378-5173(94)90461-8

Cited by 181 publications

(100 citation statements)

References 20 publications

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“…After oral administration of titanium dioxide to rats, particles of titanium dioxide were present in the gut associated lymphoid tissue, but also in the liver, spleen, lungs and peritoneal tissues, but were not detected in the heart or the kidney (Jani et al, 1994).…”

Section: Titanium Dioxide: Uses and Intestinal Uptakementioning

confidence: 99%

Titanium and Yellow Nail Syndrome

Berglund¹

2012

Novel Strategies in Lymphedema

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Section: Titanium Dioxide: Uses and Intestinal Uptakementioning

confidence: 99%

Titanium and Yellow Nail Syndrome

Berglund¹

2012

Novel Strategies in Lymphedema

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“…The aforementioned results suggest that, in SGF+SIF, the drug-free particles retained their integrity as regards size and surface charge, which are critical features needed to augment 185 absorption via endocytosis and subsequent lymphatic transport (Jani et al, 1989(Jani et al, , 1994Shakweh et al, 2005). The increase in size observed after exposure of the particles to the media may be a result of either aggregation or ingress of the dissolution media into the particles or both.…”

mentioning

confidence: 93%

Correlating gastric emptying of amphotericin B and paracetamol solid lipid nanoparticles with changes in particle surface chemistry

Amekyeh

Billa

Roberts

2017

International Journal of Pharmaceutics

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Oral delivery of pharmaceuticals requires that they retain their physical and chemical attributes during transit within the gastrointestinal (GI) tract, for the manifestation of desired therapeutic profiles. Solid lipid nanoparticles (SLNs) are used as carriers to improve the absorption of hydrophobic drugs. In this study, we examine the stability of amphotericin B (AmB) and 5 paracetamol (PAR) SLNs in simulated GI fluids during gastric emptying. On contact with the simulated fluids, the particles increased in size due to ingress of the dissolution media into the particles. Simulated gastric emptying revealed that the formulations had mean sizes < 350 nm and neutral surface charges, both of which are optimal for intestinal absorption of SLNs. There was ingress of the fluids into the SLNs, followed by diffusion of the dissolved drug, whose rate 10 depended on the solubility of the loaded-drug in the particular medium. Time-of-flight secondary ion mass spectrometry analyses indicated that drug loading followed the core-shell model and that the AmB SLNs have a more drug-enriched core than the PAR SLNs do. The AmB SLNs are therefore a very suitable carrier of AmB for oral delivery. The stability of the SLNs in the simulated GI media indicates their suitability for oral delivery.

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“…Bioavailability, quantified as blood concentration of silver, was 1.2% following treatment with 1 mg/kg body weight NPs and 4.2% following treatment with 10 mg/kg. Pioneering work in this field investigated other insoluble particles, such as 500 nm rutile titanium dioxide, and demonstrated uptake by gut-associated lymphoid tissue (Jani et al, 1994). Other NM categories such as vitamin B1-coated NPs have also been tested in vivo (Salman et al, 2007).…”

Section: In Vivo Animal Modelsmentioning

confidence: 99%

Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

Venema²,

et al. 2014

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Engineered metal/mineral, lipid and biochemical macromolecule nanomaterials (NMs) have potential applications in food. Methodologies for the assessment of NM digestion and bioavailability in the gastrointestinal tract are nascent and require refinement. A working group was tasked by the International Life Sciences Institute NanoRelease Food Additive project to review existing models of the gastrointestinal tract in health and disease, and the utility of these models for the assessment of the uptake of NMs intended for food. Gastrointestinal digestion and absorption could be addressed in a tiered approach using in silico computational models, in vitro non-cellular fluid systems and in vitro cell culture models, after which the necessity of ex vivo organ culture and in vivo animal studies can be considered. Examples of NM quantification in gastrointestinal tract fluids and tissues are emerging; however, few standardized analytical techniques are available. Coupling of these techniques to gastrointestinal models, along with further standardization, will further strengthen methodologies for risk assessment.

show abstract

Titanium dioxide (rutile) particle uptake from the rat GI tract and translocation to systemic organs after oral administration

Cited by 181 publications

References 20 publications

Titanium and Yellow Nail Syndrome

Titanium and Yellow Nail Syndrome

Correlating gastric emptying of amphotericin B and paracetamol solid lipid nanoparticles with changes in particle surface chemistry

Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

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