Titanium-strip cranioplasty.

Blair, G. A. S.; Fannin, T. F.; Gordon, Danica

doi:10.1136/bmj.2.6041.907

Cited by 18 publications

(7 citation statements)

References 2 publications

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“…9 From a variety of different repair materials, titanium mesh has become a popular material for cranioplasty due to its good compatibility with human tissue, light weight, thinness, hardness, and ability to be easily shaped. 1,10,13 In recent years, digital computer techniques have been widely used for molding titanium mesh for cranioplasty. 2,11,12 In this technique, head CT scan data, obtained from the contralateral side of the skull defect, is…”

mentioning

confidence: 99%

Comparison of manually shaped and computer-shaped titanium mesh for repairing large frontotemporoparietal skull defects after traumatic brain injury

Luo

Liu²,

Xie³

et al. 2012

FOC

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Object The object of this study was to compare the effects and complications of manual and computer-aided shaping of titanium meshes for repairing large frontotemporoparietal skull defects following traumatic brain injury. Methods From March 2005 to June 2011, 161 patients with frontotemporoparietal skull defects were observed. Patients were divided into 2 groups according to the repair materials used for cranioplasty: 83 cases used computer-aided shaping for the titanium mesh, whereas the remaining 78 cases used a manually shaped titanium mesh. The advantages and disadvantages of the 2 methods were compared. Results No case of titanium mesh loosening occurred in either group. Subcutaneous fluid collection, titanium mesh tilt, and temporal muscle pain were the most common complications. In the manually shaped group, there were 14 cases of effusion, 10 cases of titanium mesh tilt, and 15 cases of temporal muscle pain. In the computer-aided group, there were 6 cases of effusion, 3 cases of titanium mesh tilt, and 6 cases of temporal muscle pain. The differences were significant between the 2 groups (p < 0.05). Other common complications were scalp infection, exposure of titanium mesh, epidural hematoma, and seizures. In the computer-aided group, the operative time decreased (p < 0.01), the number of screws used was reduced (p < 0.01), and the satisfaction of patients was significantly increased (p < 0.05). Conclusions Computer-aided shaping of titanium mesh for repairing large frontotemporoparietal skull defects decreases postoperative complications and the operative duration, reduces the number of screws used, increases the satisfaction of patients, and restores the appearance of the patient's head, making it an ideal choice for cranioplasty.

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mentioning

confidence: 99%

Comparison of manually shaped and computer-shaped titanium mesh for repairing large frontotemporoparietal skull defects after traumatic brain injury

Luo

Liu²,

Xie³

et al. 2012

FOC

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“…For example, recombinant human bone morphogenetic proteins (rhBMPs) were found to induce osteogenesis 32 and have since been successfully translated into clinical use. 74 Combinatorial approaches incorporating BMPs like BMP-2 or BMP-7 have since been developed [75][76][77][78] and we have also shown that discontinuous triphasic release of BMP from polycaprolactone (PCL) scaffolds led to a higher bone volume fraction and trabecular thickness. 79 To provide an alternative to or complement BMPs, You et al intensively studied heparan sulfates (HS), which are glycosaminoglycan sugars.…”

Section: Surface Modification Strategiesmentioning

confidence: 96%

Emerging translational research on magnetic nanoparticles for regenerative medicine

et al. 2015

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Regenerative medicine, which replaces or regenerates human cells, tissues or organs, to restore or establish normal function, is one of the fastest-evolving interdisciplinary fields in healthcare. Over 200 regenerative medicine products, including cell-based therapies, tissue-engineered biomaterials, scaffolds and implantable devices, have been used in clinical development for diseases such as diabetes and inflammatory and immune diseases. To facilitate the translation of regenerative medicine from research to clinic, nanotechnology, especially magnetic nanoparticles have attracted extensive attention due to their unique optical, electrical, and magnetic properties and specific dimensions. In this review paper, we intend to summarize current advances, challenges, and future opportunities of magnetic nanoparticles for regenerative medicine.

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“…Titanium strips have been used to repair skull defects in situations where pre-formed metal plates are not obtainable and wiring is not adequate [72]. This particular method is simple, does not require dissection of the dura mater, and offers better resistance to additional impact injury than an inlay technique [72]. The strips of titanium IMI 115, 0-6mm thick, are cut to numerous widths and lengths as shown in Table 4.…”

Section: Titanium-strips Cranioplastymentioning

confidence: 99%

Germanium glass polyalkenoate cements for cranioplasty fixation

Khader¹

2021

Preprint

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Glass polyalkenoate cements (GPCs) have potential for skeletal cementation. Unfortunately, commercial GPCs all contain and subsequently release aluminum ions, which have been implicated in degenerative brain disease. The purpose of this research was to create aluminum free GPCs constructed from silicate (SiO2)-calcium (CaO)-zinc (ZnO), glasses mixed with polyacrylic acid (PAA200) in order to evaluate the potential of these novel GPCs for attaching titanium miniplates directly to the skull, a clinical procedure known as cranioplasty. Three glasses were formulated: KBT01 SiO2-CaO-ZnO-sodium (Na2O) glass, KBT02 SiO2-CaO-ZnO-Na2Ogermanium (GeO2), with a 0.03 mol% GeO2 substitution for ZnO and KBT03 SiO2-CaO-ZnONa2O- GeO2, with a 0.06 mol% GeO2 substitution for ZnO in glass structure. X-ray diffraction (XRD) and particle size analysis (PSA) confirmed that all glasses were completely amorphous with similar mean particle sizes. Each glass in the series was mixed with 50 wt% a patented SiO2- CaO-ZnO-strontium (SrO) glass composition, BT101, and subsequently mixed with PAA200 at 50 wt% addition to produce a series of cements. The addition of Ge to the glass series resulted in decreased working times (~142 s to 112 s) and setting times (~807 to 448 s) for the cements manufactured from them. This was due to the increase in crosslink formation during the setting reaction between the Ge-containing glasses and the PAA200. Regarding ion release, Atomic Absorption Spectroscopy (AAS) determined Zn2+ ion release to be 9.56, 8.02 and 5.83 ppm after 30 days for KBT01, KBT02 and KBT03 cements respectively. Germanium ions were not released from the KBT01 cement since the glasses it was formulated from did not contain Ge4+. KBT02 and KBT03 cements released 1.23 ppm and 1.94 ppm of Ge4+ ions after 30 days. The mechanical properties (compressive ~ σc, and biaxial flexural strength ~ σf) of the resulting cements were of the resulting cements were examined over three time modalities, 1, 7 and 30 days. σc of the cements ranged from ~27- 56 MPa, while σf ranged from ~17-33 MPa. Both strength modalities increased with maturation and increasing Ge content, as Ge may facilitate improved chemical bonding between the COO- groups, thus creating stronger cements in KBT02 and KBT03. The bond strength of the titanium cylinder (Ti) to the bone that it was attached to by the cements increased from ~0.23MPA to 0.63 MPa respectively from placement up to 14 days maturation. Failure of these constructs occurred at the interface between the Ti cylinder and the cement. The results of this research indicate that, due to their novel composition, Ge-based GPCs have suitable handling properties, strengths and adhesiveness for potential in cranioplasty fixation.

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Titanium-strip cranioplasty.

Cited by 18 publications

References 2 publications

Comparison of manually shaped and computer-shaped titanium mesh for repairing large frontotemporoparietal skull defects after traumatic brain injury

Comparison of manually shaped and computer-shaped titanium mesh for repairing large frontotemporoparietal skull defects after traumatic brain injury

Emerging translational research on magnetic nanoparticles for regenerative medicine

Germanium glass polyalkenoate cements for cranioplasty fixation

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