Titanium Tetraisopropoxide

Abstract

This feature focuses on a reagent chosen by a postgraduate, highlighting the uses and preparation of the reagent in current research Titanium TetraisopropoxideCompiled by Óscar López Óscar López was born in Seville (Spain) in 1976 and studied chemistry in the University of Seville, where he received his diploma in 1999. He is currently finishing his PhD studies at the same University, in the Department of Organic Chemistry, under the supervision of Professor José G. Fernández-Bolaños. His research field is new synthetic approaches to carbohydrate-derived thioureas, isoureas, ureas, and selenoureas.

Synthesis of 4-Hydroxy-4-Methylcyclohex-2-En-1-One

“…The 1 H NMR spectrum of hydroperoxide 9 displays an AB system, which corresponds to olefinic protons. The seven-line 13 C NMR spectrum is decisive. IR displays a bond at 3360 cm -1 for hydroperoxy group.…”

“…IR displays a bond at 3360 cm -1 for hydroperoxy group. Reduction of the peroxide linkage [11][12] in 9 was performed with dimethyl sulfide 13 / Ti(Oi-Pr) 4 under very mild conditions to give 4-hydroxy-4-methylcyclohex-2en-1-one (1) in 97% yield (Scheme 4).…”

“…IR spectra were recorded on a Mattson 1000 FT-IR spectrometer. 1 H and 13 4-methylcyclohex-3-en-1-one (8): To a magnetically stirred solution of 7 8 , 15 g (0.12 mol) in 150 ml of diethyl ether, was added a solution of 2M oxalic acid (100 ml) in water at room temperature. After complete addition (10 min), the mixture was stirred for 1.5 h. The organic phase was separated, washed with 150 ml of water and then dried over MgSO 4 .…”

“…1 H NMR (200 MHz, CDCl 3 ): δ 5.28 (bs, olefin, 1H), 2.12-2.66 (m, methylene, 6H), 1.62 (s, CH 3 , 3H). 13 C NMR (50 MHz, CDCl 3 ): δ 212.2, 136.5, 131.6, 41.4, 40.2, 32.2, 24.7.…”

Thiosugar Nucleosides. Effect of Sulfur in the Synthesis of Substituted Azido‐5‐Thio‐D‐Gluco‐ and Allopyranosyl‐N‐Nucleosides and New Isothionucleoside Derivatives Thereof

“…By emplyoing Lopez' procedure, [37] 20 was subjected for opening of the 2,3epoxy ring by the azide ions, using titanium tetraisopropoxide [Ti(i-PrO) 4 ] as a Lewis acid catalyst in the presence of triethyl amine (Sch. 4) to afford 21 in 52% yield.…”