Titaniumdioxide mediated sonophotodynamic therapy against prostate cancer

Aksel, Mehran; Kesmez, Ömer; Yavaş, Adem; Bilgin, Mehmet

doi:10.1016/j.jphotobiol.2021.112333

Cited by 28 publications

(12 citation statements)

References 39 publications

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“…The cells exposed to the PS were subjected to 0.5 W/cm 2 US and/or 0.5 W/cm 2 light irradiation. Also, in this case, the undoubted synergy of PDT and SDT was observed [117] . PDT has found an extremely wide application as a method of killing bacteria [4,10] .…”

Section: Combination Of Two Methods (Sdt+pdt)mentioning

confidence: 62%

“…[116] An interesting development of the SPDT technique was proposed by Aksel et al using extremely popular in the pharmaceutical world nanoparticles of TiO 2 . [117] TiO 2 nanoparticles have been utilized as the basic active substance due to their photodynamic properties. [118] It was used against prostate cancer cells (PC3 cell line).…”

Section: Combination Of Two Methods (Sdt + Pdt)mentioning

confidence: 99%

“…Also, in this case, the undoubted synergy of PDT and SDT was observed. [117] PDT has found an extremely wide application as a method of killing bacteria. [4,10] An interesting but poorly studied extension of PACT is its combination with SDT.…”

Section: Combination Of Two Methods (Sdt + Pdt)mentioning

confidence: 99%

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Excited State and Reactive Oxygen Species against Cancer and Pathogens: A Review on Sonodynamic and Sono‐Photodynamic Therapy

Wysocki

Czarczyńska-Goślińska

Ziental

et al. 2022

ChemMedChem

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Photodynamic and sonodynamic therapy are therapies having great potential in the treatment of bacterial infections and cancer. Their background is associated with photo-and sonosensitizers -substances that can be excited when exposed to light or ultrasound. These sensitizers belong to a various groups of compound, including porphyrins, porphyrazines, and phthalocyanines. Releasing the energy when returning to the ground state can occur in the manner of transferring it to oxygen molecules, leading to reactive oxygen species able to disrupt membranes of bacterial and cancer cells, leaving the organism's cells unaffected. In recent years, the number of reports on numerous sensitizers being effective has been constantly growing. Therefore, the development of this field may prove beneficial for dealing with cancer and microbes. This review describes the development of photodynamic and sonodynamic therapy, as well as their combination, with emphasis on sonodynamic therapy and its potential in the treatment of cancer and bacterial infections.

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Section: Combination Of Two Methods (Sdt+pdt)mentioning

confidence: 62%

Section: Combination Of Two Methods (Sdt + Pdt)mentioning

confidence: 99%

See 1 more Smart Citation

Excited State and Reactive Oxygen Species against Cancer and Pathogens: A Review on Sonodynamic and Sono‐Photodynamic Therapy

Wysocki

Czarczyńska-Goślińska

Ziental

et al. 2022

ChemMedChem

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show abstract

“…Non-photobleached, low-toxic and low-cost TiO 2 nanoparticles have been reported to provide ultrasound-induced ROS generation efficiency [ 175 ]. Yuan et al developed the MRI-guided PCa therapy based on the targeted drug nanosystem TiO 2 :Gd@DOX/FA activated by ultrasound [ 162 ].…”

Section: The Latest Advances In Preclinical Researches Of Pdt/sdt For...mentioning

confidence: 99%

Emerging photodynamic/sonodynamic therapies for urological cancers: progress and challenges

Zhang

Liu

et al. 2022

J Nanobiotechnol

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Photodynamic therapy (PDT), and sonodynamic therapy (SDT) that developed from PDT, have been studied for decades to treat solid tumors. Compared with other deep tumors, the accessibility of urological tumors (e.g., bladder tumor and prostate tumor) makes them more suitable for PDT/SDT that requires exogenous stimulation. Due to the introduction of nanobiotechnology, emerging photo/sonosensitizers modified with different functional components and improved physicochemical properties have many outstanding advantages in cancer treatment compared with traditional photo/sonosensitizers, such as alleviating hypoxia to improve quantum yield, passive/active tumor targeting to increase drug accumulation, and combination with other therapeutic modalities (e.g., chemotherapy, immunotherapy and targeted therapy) to achieve synergistic therapy. As WST11 (TOOKAD® soluble) is currently clinically approved for the treatment of prostate cancer, emerging photo/sonosensitizers have great potential for clinical translation, which requires multidisciplinary participation and extensive clinical trials. Herein, the latest research advances of newly developed photo/sonosensitizers for the treatment of urological cancers, and the efficacy, as well as potential biological effects, are highlighted. In addition, the clinical status of PDT/SDT for urological cancers is presented, and the optimization of the photo/sonosensitizer development procedure for clinical translation is discussed.

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“…In contrast, both the 1 O 2 and • OH radicals were evident after SDT and PSDT treatments, and the combination therapy showed improved ROS generation efficacy compared to the monotherapies ( Nene and Nyokong, 2021 ). Aksel et al (2021) found that malondialdehyde (MDA) levels were increased while superoxide dismutase activity (SOD), catalase (CAT), and glutathione (GSH) levels were decreased after TiO 2 -mediated SPDT ( Aksel et al, 2021 ).…”

Section: Sonodynamic Therapymentioning

confidence: 99%

The crosstalk between sonodynamic therapy and autophagy in cancer

et al. 2022

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As a noninvasive treatment approach for cancer and other diseases, sonodynamic therapy (SDT) has attracted extensive attention due to the deep penetration of ultrasound, good focusing, and selective irradiation sites. However, intrinsic limitations of traditional sonosensitizers hinder the widespread application of SDT. With the development of nanotechnology, nanoparticles as sonosensitizers or as a vehicle to deliver sonosensitizers have been designed and used to target tissues or tumor cells with high specificity and accuracy. Autophagy is a common metabolic alteration in both normal cells and tumor cells. When autophagy happens, a double-membrane autophagosome with sequestrated intracellular components is delivered and fused with lysosomes for degradation. Recycling these cell materials can promote survival under a variety of stress conditions. Numerous studies have revealed that both apoptosis and autophagy occur after SDT. This review summarizes recent progress in autophagy activation by SDT through multiple mechanisms in tumor therapies, drug resistance, and lipid catabolism. A promising tumor therapy, which combines SDT with autophagy inhibition using a nanoparticle delivering system, is presented and investigated.

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Titaniumdioxide mediated sonophotodynamic therapy against prostate cancer

Cited by 28 publications

References 39 publications

Excited State and Reactive Oxygen Species against Cancer and Pathogens: A Review on Sonodynamic and Sono‐Photodynamic Therapy

Excited State and Reactive Oxygen Species against Cancer and Pathogens: A Review on Sonodynamic and Sono‐Photodynamic Therapy

Emerging photodynamic/sonodynamic therapies for urological cancers: progress and challenges

The crosstalk between sonodynamic therapy and autophagy in cancer

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