TLC data in QSAR assay of thiazole and benzothiazole derivatives with H₁-antihistamine activity. Part 2

Development and Validation of Quantitative Structure-Activity Relationship Models for Compounds Acting on Serotoninergic Receptors

“…Similar studies have been carried out on compounds toward β -adrenergic [47, 48] and histamine [49–52] receptors.…”

“…The present work is a continuation of the previous studies [ 13 , 14 ], whose purpose is to determine the possibility of using data obtained from thin-layer chromatography and computer-calculated physicochemical parameters to build regression equations that will predict the receptor binding affinity (p K i ) and agonist (p D 2 ) and antagonistic (p A 2 ) activity of selected compounds acting on serotoninergic receptors. Similar studies have been carried out on compounds toward β -adrenergic [ 47 , 48 ] and histamine [ 49 – 52 ] receptors.…”

Normal and reversed phase thin layer chromatography data in quantitative structure–activity relationship study of compounds with affinity for serotonin (5-HT) receptors

“…On the basis of this information and our previous studies [56][57][58][59][60][61] this research explored the possibility to use chromatographic methods and physicochemical data for determination of receptor-binding potential (pK i ), agonistic (pD 2 ) and antagonistic (pA 2 ) activity of 20 compounds with proven affinity to serotonin receptors. The study took advantage of the data concerning the structure and function of this receptor [12][13][14][15][16][17][18][19][20][21][22].…”