2014
DOI: 10.1177/1721727x1401200314
|View full text |Cite
|
Sign up to set email alerts
|

TLR4 and TLR9 Polymorphisms Effect on Inflammatory Response in End-Stage Renal Disease Patients

Abstract: Toll-like receptors (TLRs) playa key role in the response of innate and adaptive immune system to microbial and endogenous ligands. Inflammation is a common feature in end-stage renal disease (ESRD) patients; however, the mechanisms/factors triggering the inflammatory process are still poorly clarified. Our aim was to analyze the impact of the c.-1486T>C and c.896A>G polymorphisms in TLR9 and TLR4 genes, respectively, on the inflammatory response of ESRD patients. Clinical and laboratory evaluation was carried… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
3
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
(3 citation statements)
references
References 28 publications
0
3
0
Order By: Relevance
“…Furthermore, TLRs have also been implicated as potential drivers of cisplatin-induced pathologies and toxicities, including AKI [ 55 , 218 , 219 ]; renal injury [ 220 , 221 , 222 ]; allodynia [ 218 ]; and ototoxicity [ 223 ]. As demonstrated by TLR-deficient animal models [ 55 , 218 , 219 ] and polymorphisms in humans [ 224 , 225 , 226 , 227 ], the absence or improper function of TLRs may influence susceptibility and severity of pathologies affecting the renal system. Therefore, immunopathological consequences and renoprotective abilities originating from TLR activation in CIAKI are described.…”
Section: Cisplatin-induced Acute Kidney Injury: Role Of the Immunementioning
confidence: 99%
“…Furthermore, TLRs have also been implicated as potential drivers of cisplatin-induced pathologies and toxicities, including AKI [ 55 , 218 , 219 ]; renal injury [ 220 , 221 , 222 ]; allodynia [ 218 ]; and ototoxicity [ 223 ]. As demonstrated by TLR-deficient animal models [ 55 , 218 , 219 ] and polymorphisms in humans [ 224 , 225 , 226 , 227 ], the absence or improper function of TLRs may influence susceptibility and severity of pathologies affecting the renal system. Therefore, immunopathological consequences and renoprotective abilities originating from TLR activation in CIAKI are described.…”
Section: Cisplatin-induced Acute Kidney Injury: Role Of the Immunementioning
confidence: 99%
“…The TLR4 receptor is likely to be associated with several diseases because of the range of ligands (both pathogen-related and endogenous) identified as agonists of TLR4 [ 25 ]. TLR4 is linked to a range of diseases with potential treatments targeting the TLR4 pathway [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ]. TLR4 activation can not only cause antitumor immunity but also, conversely, promote immunosuppression and influence tumor growth [ 68 ].…”
Section: Introductionmentioning
confidence: 99%
“…Single nucleotide polymorphisms (SNPs) in CASP1, CRP, IL1B, IL2, IL6, IL6R, IL10, TGFB, and TNF can increase or decrease the protein production and/or function of these pro-and antiinflammatory mediators in vitro (Kroeger et al, 1997;Turner et al, 1997;Awad et al, 1998;Hoffmann et al, 2001;Dunning et al, 2003;Hall et al, 2004;Trompet et al, 2008;Wang et al, 2009) or serum/plasma concentrations in vivo (Fishman et al, 1998;Grainger et al, 1999;Galicia et al, 2004;Smith et al, 2008;Lacruz-Guzmán et al, 2013). In addition, SNPs in the MyD88dependent TLR signaling pathway affect innate immune responses to vaccines (Ovsyannikova et al, 2011) and susceptibility to infection or disease in vivo (Taniguchi et al, 2013;Santos-Martins et al, 2014). Therefore, these innate immunogenetic markers may serve as predictors of acute rejection post-kidney transplantation.…”
Section: Introductionmentioning
confidence: 99%