2021
DOI: 10.1186/s43141-021-00218-y
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TLR4 gene polymorphisms in Egyptian vitiligo patients: insights into emerging association with clinical activity, family history, and response to therapy

Abstract: Background Vitiligo is a common pigmentary disorder in which autoimmunity has been suggested to play an important role. Toll-like receptor (TLR) family are recognized different molecular structures expressed on immune cells and have been implicated in a number of autoimmune diseases (AIDs) such as vitiligo. The purpose of this study was to investigate the possible association between TLR4 gene polymorphisms: rs11536858, rs1927911, rs1927914 in Egyptian vitiligo patients and their clinical data,… Show more

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Cited by 6 publications
(2 citation statements)
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“…The innate immunity has evident role in pathogenesis of autoimmune diseases (Abdelsalam et al 2021 ). Assuming that antibodies released from previous vaccination, so the second hypothesis depends upon the vaccine may cause misguided trained innate immune response which can contribute to chronic hyperinflammatory state leading to disease progression, organ damage and case deterioration after infection with SARS-CoV-2 virus.…”
Section: Discussionmentioning
confidence: 99%
“…The innate immunity has evident role in pathogenesis of autoimmune diseases (Abdelsalam et al 2021 ). Assuming that antibodies released from previous vaccination, so the second hypothesis depends upon the vaccine may cause misguided trained innate immune response which can contribute to chronic hyperinflammatory state leading to disease progression, organ damage and case deterioration after infection with SARS-CoV-2 virus.…”
Section: Discussionmentioning
confidence: 99%
“…Vitiligo is a pigmentary disease in which immune imbalance has been approved to play a role 1 . The skin, hair, and nails are covered by white patches of different sizes and shapes 2 .…”
Section: Introductionmentioning
confidence: 99%