2022
DOI: 10.1093/neuonc/noac209.1119
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Tmic-76. Humanin Release From Tumor Associated Myeloid Cells Promotes Glioma Chemoresistance

Abstract: Transcriptomic screens of brain tumor (glioblastoma; GBM) parenchymal cells indicated tumor supporting traits of the GBM microenvironment, but largely excluded mitochondrially enriched gene-sets. Here, we show that a mitochondrial transcript of GBM parenchymal cells contributes to therapy resistance. We inspected the non-coding transcriptome of human GBM associated myeloid cells (GAM) and observed an upregulation of the mitochondrial ribosomal subunit MT-RNR2, which contains an open reading frame for the signa… Show more

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