TMT proteomic analysis for molecular mechanism of Staphylococcus aureus in response to freezing stress

Bai, Xue; Xu, Ying; Shen, Yong; Guo, Na

doi:10.1007/s00253-022-11927-w

Cited by 5 publications

(1 citation statement)

References 53 publications

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“…The growth and spread of pathogenic bacteria that are multidrug resistant (multidrug-resistant strains) have been on the rise recently, and biofilm formation is antibiotic resistant and challenging to cure. The urgent need for alternate therapeutic approaches to treat illnesses brought on by these bacterial pathogens is highlighted by this (17). Probiotics are currently used widely over the globe as their health benefits have come to light.…”

Section: Discussionmentioning

confidence: 99%

Impact of cell-free supernatant of lactic acid bacteria on Staphylococcus aureus biofilm and its metabolites

et al. 2023

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IntroductionA safe bio-preservative agent, lactic acid bacteria (LAB) can inhibit the growth of pathogenic bacteria and spoilage organisms. Its cell-free supernatant (LAB-CFS), which is rich in bioactive compounds, is what makes LAB antibacterial work.MethodsThis study focused on the changes in biofilm activity and related metabolic pathways of S. aureus treated with lactic acid bacteria planktonic CFS (LAB-pk-CFS) and biofilm state (LAB-bf-CFS).ResultsThe findings demonstrated that the LAB-CFS treatment considerably slowed Staphylococcus aureus (S. aureus) growth and prevented it from forming biofilms. Additionally, it inhibits the physiological traits of the S. aureus biofilm, including hydrophobicity, motility, eDNA, and PIA associated to the biofilm. The metabolites of S. aureus biofilm treated with LAB-CFS were greater in the LAB-bf-CFS than they were in the LAB-pk-CFS, according to metabolomics studies. Important metabolic pathways such amino acids and carbohydrates metabolism were among the most noticeably altered metabolic pathways.DiscussionThese findings show that LAB-CFS has a strong potential to combat S. aureus infections.

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Section: Discussionmentioning

confidence: 99%