TNF-α and MTHFR Polymorphisms Associated with Cerebral Palsy in Chinese Infants

Hou, Ruiying; Ren, Xiuyu; Wang, Juan; Guan, Xujun

doi:10.1007/s12035-015-9566-7

Cited by 12 publications

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“…In total 1,117 cases and 3,563 controls were eligible and included in this study; the sample size ranged from 74 participants ( 6 ) to 1,741 participants ( 15 ). All included studies were observational in nature, including three cohort studies ( 6 , 7 , 10 ), four case-control studies ( 5 , 8 , 9 , 14 ) and one randomized controlled trial ( 11 , 13 ). Four studies were conducted in the United States ( 8 , 10 , 11 , 14 ), two studies were conducted in Europe ( 6 , 7 ), one study was conducted in Australia, ( 15 ) and the others were conducted in China ( 5 , 9 ).…”

Section: Resultsmentioning

confidence: 99%

“…All included studies were observational in nature, including three cohort studies ( 6 , 7 , 10 ), four case-control studies ( 5 , 8 , 9 , 14 ) and one randomized controlled trial ( 11 , 13 ). Four studies were conducted in the United States ( 8 , 10 , 11 , 14 ), two studies were conducted in Europe ( 6 , 7 ), one study was conducted in Australia, ( 15 ) and the others were conducted in China ( 5 , 9 ). Of the five studies conducted at the beginning of the neonatal period before the diagnosis of CP, two collected blood samples from cord blood ( 6 , 14 ) and three from venous blood ( 8 , 10 , 11 ), and all four infant studies collected venous blood samples ( 5 , 7 , 9 , 15 ).…”

Section: Resultsmentioning

confidence: 99%

“…Four studies were conducted in the United States ( 8 , 10 , 11 , 14 ), two studies were conducted in Europe ( 6 , 7 ), one study was conducted in Australia, ( 15 ) and the others were conducted in China ( 5 , 9 ). Of the five studies conducted at the beginning of the neonatal period before the diagnosis of CP, two collected blood samples from cord blood ( 6 , 14 ) and three from venous blood ( 8 , 10 , 11 ), and all four infant studies collected venous blood samples ( 5 , 7 , 9 , 15 ). The methods used to assess TNF-α differed among the studies, two studies used Enzyme-linked Immunoassay (ELISA) ( 5 , 14 ), three studies used SNP analysis ( 7 , 9 , 15 ) and four used cytometry techniques, including Cytometric Bead Array (CBA) ( 6 ), Meso Scale Discovery (MSD) electrochemiluminescence system ( 8 , 10 ), Multiplex Luminex Assay ( 11 ).…”

Section: Resultsmentioning

confidence: 99%

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Relationship Between TNF-α and the Risk of Cerebral Palsy: A Systematic Review and Meta-Analysis

Wang

Wang²,

Wu³

et al. 2022

Front. Neurol.

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ObjectiveWe performed a meta-analysis to investigate the relationship between blood tumor necrosis factor-alpha (TNF-α) levels and the risk of cerebral palsy (CP) in children.MethodsPubMed, Web of Science, Cochrane Library and Ovid databases were searched from the date of database inception to 26 April 2022. Data were extracted and pooled from observational studies related to TNF-α and the risk of CP in children. Quality was assessed using the Newcastle-Ottawa Scale. We used the inverse variance method with a random-effects model to estimate the odds ratios with 95% confidence intervals (CIs), and stratified analyses and sensitivity analysis were utilized to analyse heterogeneity.ResultsNine studies with 1,117 cases and 3,563 controls were included in our meta-analysis. The quality of the literature was good, and no publication bias was noted. According to the random-effects model, blood TNF-α levels were associated with the risk of CP (OR 1.82; 95% CI, 1.25–2.66) in a heterogeneous set of studies (I2 = 81.2%, p = 0.000).ConclusionOur findings indicate that elevated TNF-α levels in the blood are associated with an increased risk of CP. The association of TNF-α with CP requires further investigation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Relationship Between TNF-α and the Risk of Cerebral Palsy: A Systematic Review and Meta-Analysis

Wang

Wang²,

Wu³

et al. 2022

Front. Neurol.

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“…It implied that MLEC may also play roles in macrophage polarization. Genetic polymorphisms play important roles in the pathogenesis of CP . Therefore, we focused on the potential association of SNPs with the risk of CP.…”

Section: Discussionmentioning

confidence: 99%

Malectin gene polymorphisms promote cerebral palsy via M2‐like macrophage polarization

et al. 2018

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The relationship between gene polymorphisms and the pathogenesis of cerebral palsy (CP) is uncovering recently. Here, we suggested that single nucleotide polymorphisms (SNPs) of MLEC gene might take part in the pathogenesis of CP. We genotyped and analyzed 6 SNP positions of MLEC gene in 916 CP patients and 957 healthy people, which are from the Chinese Han population. The results indicated significant associations between the risk of CP and rs10431386 [allele: P-value = .006, odds ratio (OR) = 1.587, 95% confidence interval (CI) = 1.198-1.967] and rs7964786 [allele: P-value = .005, OR = 1.956, 95% CI = 1.238-2.519] SNP positions of MLEC gene. Further investigations revealed that C alleles of rs10431386 and rs7964786 inhibit the expression of MLEC in blood of CP patients and macrophage cell line. in vitro experiments revealed that MLEC promotes M1 to M2 macrophage polarization. The results of in vitro studies suggest that C alleles of rs10431386 and rs7964786 on MLEC promotes CP by inhibiting M1 to M2 macrophage polarization. Generally, this work suggested the contribution of MLEC gene polymorphisms to the pathogenesis of CP.

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“…However, the causes of CP are unknown in most individuals. An increasing association studies have explored the interactions between the susceptibility to CP and SNPs of candidate genes, including those involved in the inflammatory system and the coagulation cascade such as coagulation factor II/ V /VII, lymphotoxin-alpha, tumor necrosis factor, IL-6, and IL-8, to determine whether they contribute to the causal pathway of CP [ 11 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

Association of NOS1 gene polymorphisms with cerebral palsy in a Han Chinese population: a case-control study

Xia

et al. 2018

BMC Med Genomics

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BackgroundCerebral palsy (CP) is the leading cause of motor disability in children; however, its pathogenesis is unknown in most cases. Growing evidence suggests that Nitric oxide synthase 1 (NOS1) is involved in neural development and neurologic diseases. The purpose of this study was to determine whether genetic variants of NOS1 contribute to CP susceptibility in a Han Chinese population.MethodsA case-control study involving 652 CP patients and 636 healthy controls was conducted. Six SNPs in the NOS1 gene (rs3782219, rs6490121, rs2293054, rs10774909, rs3741475, and rs2682826) were selected, and the MassARRAY typing technique was applied for genotyping. Data analysis was conducted using SHEsis online software, and multiple test corrections were performed using SNPSpD online software.ResultsThere were no significant differences in genotype and allele frequencies between patients and controls for the SNPs except rs6490121, which deviated from Hardy-Weinberg equilibrium and was excluded from further analyses. Subgroup analysis revealed differences in genotype frequencies between the CP with neonatal encephalopathy group (CP + NE) and control group for rs10774909, rs3741475, and rs2682826 (after SNPSpD correction, p = 0.004, 0.012, and 0.002, respectively). The T allele of NOS1 SNP rs3782219 was negatively associated with spastic quadriplegia (OR = 0.742, 95% CI = 0.600–0.918, after SNPSpD correction, p = 0.023). There were no differences in allele or genotype frequencies between CP subgroups and controls for the other genetic polymorphisms.ConclusionsNOS1 is associated with CP + NE and spastic quadriplegia, suggesting that NOS1 is likely involved in the pathogenesis of CP and that it is a potential therapeutic target for treatment of cerebral injury.Electronic supplementary materialThe online version of this article (10.1186/s12920-018-0374-6) contains supplementary material, which is available to authorized users.

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TNF-α and MTHFR Polymorphisms Associated with Cerebral Palsy in Chinese Infants

Cited by 12 publications

References 28 publications

Relationship Between TNF-α and the Risk of Cerebral Palsy: A Systematic Review and Meta-Analysis

Relationship Between TNF-α and the Risk of Cerebral Palsy: A Systematic Review and Meta-Analysis

Malectin gene polymorphisms promote cerebral palsy via M2‐like macrophage polarization

Association of NOS1 gene polymorphisms with cerebral palsy in a Han Chinese population: a case-control study

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