TNF-α mutation affects the gene expression profiles of patients with multiple trauma

Gt, Chen; Han, Ning; Gf, Li; Li, X; Li, G; Yz, Liu; Wu, Wenjuan; Wang, Y; Yx, Chen; Sun, GX; Zc, Li; Li, QC

doi:10.1177/1721727x15588433

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…9 From the several classes of polymers studied, membranes prepared from aromatic polyimides have shown remarkable properties: thermal stability, mechanical strength, spinnability, electrical properties, and chemical resistance. [10][11][12][13] Fluorinated polyimides, in particular, have shown to be the frontrunner among all their peers. 14,15 A general method of preparing polyimides consists of reacting a dianhydride monomer with a diamine one.…”

Section: Introductionmentioning

confidence: 99%

Fluorinated copolyimide membranes for sour mixed‐gas upgrading

Hayek

Yahaya

Alsamah

et al. 2019

J of Applied Polymer Sci

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Three random and two block 4,4 0 -(hexafluoroisopropylidene)diphthalic anhydride (6FDA)-based copolyimides with different 6FpDA:Durene molar ratio varying from 25 to 80% were prepared and characterized. The pure-gas permeation data of their membranes were investigated at 100 psi and 22 C. The CO 2 /CH 4 ideal selectivity coefficient increased to around 47 with the increase of the 6FpDA content to 80% in the copolymer backbone while the CO 2 permeability coefficient found to be the highest (378 barrer) with highest Durene content copolymer. Based on its attractive pure-gas permeation properties(CO 2 /CH 4 = 47), 6FDA-6FpDA/6FDA-Durene (4:1) block copolyimide was selected for further analyses, where the effect of pressure and temperature on its gas transport properties was evaluated. Furthermore, the mixed-gas permeation properties were investigated using multicomponent sweet and sour gas mixtures prepared from N 2 (30% or 10%), CH 4 (59%), C 2 H 6 (1%), CO 2 (10%), and H 2 S (0% or 20%)accordingly. The sweet mixed-gas CO 2 /CH 4 selectivity and CO 2 permeability coefficients of 6FDA-6FpDA/6FDA-Durene (4:1) are around 39 and 45 barrer, respectively, at elevated pressure (800 psi). The polymer, however, showed nonideal behavior when subjected to high H 2 S-content gas mixture (20 vol. % H 2 S), where the CO 2 /CH 4 selectivity value dropped to around 21 and the H 2 S/CH 4 selectivity coefficient is 13. The CO 2 and H 2 S permeability coefficients are 42 and 26 barrer, respectively, at an upstream pressure up to 500 psi. When plotted on the combined acid gas permeability-selectivity curve, the polymer separation efficiency was nearby the high-performing polymers reported in the literature, and way superior to the industrial standard glassy polymer, cellulose acetate, used currently in gas separation.

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Section: Introductionmentioning

confidence: 99%

Fluorinated copolyimide membranes for sour mixed‐gas upgrading

Hayek

Yahaya

Alsamah

et al. 2019

J of Applied Polymer Sci

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“…These inflammatory mediators stimulate and sensitize neurons in the superficial dorsal horn and generate enhanced pain, e.g. , TNF‐α exerts a positive feedback effect in the stimulation of microglia activation and generates much more severe inflammation (Gu et al, 2015) via a series of gene expression (Chen et al, 2015). Inhibition of TNF‐α decreased pain gene expression both in pre‐ clinical (Gu et al, 2015) and clinical (Carubbi et al, 2016) studies.…”

Section: Discussionmentioning

confidence: 99%

Exercise preconditioning reduces neonatal incision surgery‐induced enhanced hyperalgesia via inhibition of P38 mitogen‐activated protein kinase and IL‐1β, TNF‐α release

Gong

Jiang

Zhang³

2016

Intl J of Devlp Neuroscience

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Neonatal surgery leads to enhanced hyperalgesia to noxious stimulation in adulthood via a mechanism caused by enhanced phosphorylated (p)-p38 expression in microglia. We tested the effect of exercise on reducing enhanced hypersensitivity primed by neonatal incision surgery. Adult female Wistar rats, with or without neonatal incision surgery at postnatal day (P) 3, received right hind paw plantar incision surgery under anesthesia at P44. The rats performed wheel-running exercise from P22 to P41. Paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) were measured and ipsilateral spinal cords were collected for protein quantification. For PWT and PWL, exercise reduced the pain index after incision surgery at P44 in rats with neonatal surgery (P<0.01). Western blots showed that exercise suppressed P-p38 expression relative to adult rats without neonatal surgery (P<0.05). Results of ELISA showed that exercise reduced IL-1β and TNF-α (P<0.05) concentration in the ipsilateral spinal cord. Exercise preconditioning is an effective approach to reducing enhanced adult hyperalgesia primed by neonatal surgery. The mechanism may be explained by exercise-induced inhibition of P-p38 activation and IL-1β, TNF-α release.

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“…Tumor necrosis factor, which participates in T1DM, is a pro-inflammatory cytokine [37] involved in the acute phase reaction, in increased vascular permeability and can be generated and released by degranulated and non-degranulated activated mast cells [38].…”

Section: Introductionmentioning

confidence: 99%

Are mast cells important in diabetes?

Kempuraj

Caraffa

Ronconi

et al. 2016

pjp

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Diabetes is a metabolic disorder characterized by hyperglycemia and associated with microvascular and macrovascular syndromes mediated by mast cells. Mast cells are activated through cross-linking of their surface high affinity receptors for IgE (FcεRI) or other antigens, leading to degranulation and release of stored inflammatory mediators, and cytokines/chemokines without degranulation. Mast cells are implicated in innate and acquired immunity, inflammation and metabolic disorders such as diabetes. Histamine and tryptase genes in mast cells are overexpressed in pancreatic tissue of type 2 diabetes mellitus (T2DM) patients. Histamine is a classic inflammatory mediator generated by activated receptors of mast cells from the histamine-forming enzyme histidine decarboxylase (HDC), which can be activated by two inflammatory chemokines, RANTES and MPC1, when injected intramuscularly or intradermally in mice. This activation is inhibited in genetically mast cell-deficient W/W v mice, which show higher insulin sensitivity and glucose tolerance. This study contributes to understanding the mechanism by which mast cells profoundly affect diabetes, and their manipulation could represent a new therapeutic strategy. However, further studies are needed to clarify the role of mast cells in inflammation and metabolic disorders such as diabetes.

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TNF-α mutation affects the gene expression profiles of patients with multiple trauma

Cited by 4 publications

References 28 publications

Fluorinated copolyimide membranes for sour mixed‐gas upgrading

Fluorinated copolyimide membranes for sour mixed‐gas upgrading

Exercise preconditioning reduces neonatal incision surgery‐induced enhanced hyperalgesia via inhibition of P38 mitogen‐activated protein kinase and IL‐1β, TNF‐α release

Are mast cells important in diabetes?

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