2024
DOI: 10.1177/19476035241297693
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TNF-α Regulated Bidirectional Interaction Between Bone Marrow Mesenchymal Stem Cells and Articular Chondrocytes

Yu Huang,
Fengqiong Zuo,
Jue Wu
et al.

Abstract: Background Articular chondrocytes (ACs) secrete a variety of extracellular matrix components to maintain the functions of articular cartilage. Degeneration of ACs leads to the degeneration of articular cartilage and consequently to osteoarthritis. The secretion of bone marrow mesenchymal stem cells (BMSCs) is capable of protecting ACs from degeneration, and thus BMSCs are widely applied to treat osteoarthritis. Objective This study aims to explore whether BMSCs and ACs will affect the functions of each other t… Show more

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