2022
DOI: 10.1016/j.celrep.2022.110657
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TNF-α sculpts a maturation process in vivo by pruning tolerogenic dendritic cells

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Cited by 17 publications
(21 citation statements)
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References 124 publications
(196 reference statements)
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“…Previous work has demonstrated that PTX treatment can promote the maturation of DCs in vitro and upregulate their production of co-stimulatory molecules [48]; that way, PTX mediates the production of pro-inflammatory cytokines, such as IL-6, IL-12, and IL-1β, in DCs, and increases T cell responses, which may lead to autoimmune diseases, in vivo [49][50][51][52]. Alternatively, PTX could be selectively toxic to the endogenous tolerogenic cDC1 population, thereby removing the restraining effect of the DC subpopulation on immunogenicity [53]. Gαi/o proteins link to Frizzled-1, and the inhibition of Gαi/o proteins by PTX blocks Wnt-3A-induced Wnt/β-catenin signal activation [54,55].…”
Section: Discussionmentioning
confidence: 99%
“…Previous work has demonstrated that PTX treatment can promote the maturation of DCs in vitro and upregulate their production of co-stimulatory molecules [48]; that way, PTX mediates the production of pro-inflammatory cytokines, such as IL-6, IL-12, and IL-1β, in DCs, and increases T cell responses, which may lead to autoimmune diseases, in vivo [49][50][51][52]. Alternatively, PTX could be selectively toxic to the endogenous tolerogenic cDC1 population, thereby removing the restraining effect of the DC subpopulation on immunogenicity [53]. Gαi/o proteins link to Frizzled-1, and the inhibition of Gαi/o proteins by PTX blocks Wnt-3A-induced Wnt/β-catenin signal activation [54,55].…”
Section: Discussionmentioning
confidence: 99%
“…Regardless, the NF-κB pathways are regulated by the TNFR1, the main receptor for TNF-alpha ( Hayden and Ghosh, 2014 ; Maney et al, 2014 ). TNFR1 is expressed at the cell surface of cDC2s and its ectodomain cleaved by the NOTCH2-pathway regulator ADAM10 ( Maney et al, 2014 ; Yang et al, 2016 ; Iberg et al, 2022 ). We showed that both TNF-alpha and sTNFR1 were higher in the secretome of activated CX3CR1+ DC3s.…”
Section: Discussionmentioning
confidence: 99%
“…Regardless, the NF-κB pathways are regulated by the TNFR1, the main receptor for TNF alpha ( 62, 63 ). TNFR1 is expressed at the cell surface of cDC2s and its ectodomain cleaved by the NOTCH2-pathway regulator ADAM10 (6365). We showed that both TNF alpha and sTNFR1 were higher in the secretome of activated CX3CR1+ DC3s.…”
Section: Discussionmentioning
confidence: 99%