TNF-β +252 A&gt;G (rs909253) polymorphism is independently associated with presence of autoantibodies in rheumatoid arthritis patients

Medeiros, Fabiano Aparecido de; Alfieri, Daniela Frizon; Iriyoda, Tatiana Mayumi Veiga; Costa, Neide Tomimura; Almeida, Elaine Regina Delicato de; Lozovoy, Marcell Alysson Batisti; Mari, Naiara Lourenço; Flauzino, Tamires; Reiche, Edna Maria Vissoci; Dichi, Isaías; Simão, Andréa Name Colado

doi:10.1007/s10238-019-00556-9

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…However, the results reported a high prevalence level of TNF‐β in AG proportion 348.8 ± 129.4 within the control group. An important finding of 30 that the genetic polymorphism +252 A/G of TNF‐β influences the expression of the level of TNF‐β cytokine, and this polymorphism is associated with the risk of many diseases such as RA, SLE, sepsis, pancreatic, and breast cancer.…”

Section: Discussionmentioning

confidence: 99%

The etiological effect and genetic risk of +252 A/G variant of TNF‐β gene related to the susceptibility of urinary tract infection in a sample of Iraqi patients with type 2 diabetes: A case control study

Abdulfattah

2023

Health Science Reports

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Background and aim Urinary tract infection (UTI) is the most common infection in type 2 diabetes patients. TNF‐β is a cytokine with multiple functions in immunomodulatory and inflammatory mechanisms. The variation at position +252 A/G of TNF‐β impacts both gene expression and plasma concentration of TNF‐β proteins. The findings may shed light on the genetic factors that predispose diabetic patients in Iraq to UTIs. Methods A total of 200 individuals were divided into 100 patients with type 2 diabetes, categorized according to UTI, and 100 control subjects. Genetic analysis of +252 A/G of the TNF‐β gene was carried out using the TaqMan probe allele discrimination method. The level of TNF‐β was estimated by the ELISA technique. Results In the recessive model (GG vs. AA/AG) of TNF‐β + 252 A/G in T2D/UTI patients compared to controls, a significant association p = 0.029 (OR: 2.8; CI 95% = 1.14–7.09): E = 15.6% was observed. Furthermore, in T2D patients without UTI, the dominant model AA versus AG/GG was associated with a preventive role P: 31.3% (OR: 0.4; CI 95% = 0.22–0.88) and a p value = (0.02). Overall, AG proportions showed a high level of TNF‐β within the control group p = 0.03, while all proportions of the +252 A/G showed significant differences in TNF‐β level between groups p ≤ 0.05. Pearson's correlation analysis observed a link between TNF‐ levels, fasting plasma glucose (FPG), and HbA1c. Conclusion In T2D patients, the G allele may be linked to a higher probability of UTI, as well as an increased level of TNF‐β in a genotype‐dependent manner.

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Section: Discussionmentioning

confidence: 99%

The etiological effect and genetic risk of +252 A/G variant of TNF‐β gene related to the susceptibility of urinary tract infection in a sample of Iraqi patients with type 2 diabetes: A case control study

Abdulfattah

2023

Health Science Reports

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“…TNF-β is a kind of cytokine produced in parts of autoimmune diseases and tumors after the stimulation of mitogen and lymphocyte antigen. Since having similar structure to the TNF-α, TNF-β belongs to the TNF family, and it can affect cell apoptosis and regulate inflammatory immunity [22]. Our previous studies found that the serum concentrations of C3, C4, C1q, FCN2, C3a, and sC5b-9 in the PSS patients were significantly higher than those in the normal control group, suggesting that the complement replacement pathway might be abnormally activated in PSS patients at onset [23].…”

Section: Introductionmentioning

confidence: 99%

HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese Population

Bai

Huang

Shen

et al. 2022

Journal of Immunology Research

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Previous studies have shown that HLA gene polymorphisms are associated with the pathogenesis of the Posner-Schlossman syndrome (PSS). This study was aimed at evaluating the associations between HLA-III gene polymorphisms and PSS in a southern Chinese Han population. A total of 150 PSS patients and 183 healthy controls were included in this study. Twenty-one single nucleotide polymorphisms (SNPs) of HLA-III genes (including HSP70-1, HSP70-2, HSP70-hom, TNF-α, TNF-β, C2, and CFB) were genotyped using the SNaPshot technique. Our study showed that the frequencies of G allele at rs909253, A allele at rs1041981, and G allele at rs2844484 of TNF-β in the patient group were significantly higher than those in healthy controls (Corrected P P c = 0.040 , OR = 1.45 ; P c = 0.033 , OR = 1.45 ; P c = 0.045 , OR = 1.58 , respectively). The frequency of T allele at rs12190359 of HSP70-1 was significantly lower in PSS patients than those in healthy controls ( P c = 0.018 and OR = 0.10 ). The frequencies of the CCT haplotype of HSP70-1 gene (rs1008438-rs562047-rs12190359) and the ACCCTTT haplotype of HSP70 gene (rs2227956-rs1043618-rs1008438-rs562047-rs12190359-rs2763979-rs6457452) were significantly lower in PSS patients than those in healthy controls ( P c = 0.024 , OR = 0.10 ; P c = 0.048 , OR = 0.10 , respectively). In conclusion, the G allele at rs909253, A allele at rs1041981, and G allele at rs2844484 of TNF-β gene might be risk factors for PSS, while the T allele at rs12190359 of HSP70-1 gene and specific haplotypes of the HSP70-1 and HSP70 genes might be protective factors for PSS.

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The association of transforming growth factor beta 1 gene polymorphisms with arthritis: a systematic review and meta-analysis

Liu

2021

Clin Exp Med

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TNF-β +252 A>G (rs909253) polymorphism is independently associated with presence of autoantibodies in rheumatoid arthritis patients

Cited by 4 publications

References 41 publications

The etiological effect and genetic risk of +252 A/G variant of TNF‐β gene related to the susceptibility of urinary tract infection in a sample of Iraqi patients with type 2 diabetes: A case control study

The etiological effect and genetic risk of +252 A/G variant of TNF‐β gene related to the susceptibility of urinary tract infection in a sample of Iraqi patients with type 2 diabetes: A case control study

HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese Population

The association of transforming growth factor beta 1 gene polymorphisms with arthritis: a systematic review and meta-analysis

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