TNFa microsatellite polymorphism modulates the risk of type 1 diabetes in the Belgian population, independent of HLA-DQ

Aminkeng, Folefac; Autreve, Jan E. Van; Koeleman, Bobby P. C.; Quartier, Erik; Schravendijk, Christiaan Van; Gorus, Frans; Auwera, Bart J. Van der

doi:10.1016/j.humimm.2007.05.001

Cited by 10 publications

(4 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, there are no previous data for Amerindian populations regarding this type of polymorphism in the TNF block. In our case, Mestizos, Tepehuanos, and Yaquis showed an allele diversity and distribution similar to those observed worldwide , in contrast to what we observed for all the Lacandonian populations.…”

Section: Discussionsupporting

confidence: 80%

“…This is reinforced by the fact that it has been observed that alleles TNFA–308A, LTA+252G, and certain TNF microsatellites are associated with susceptibility to infectious, autoimmune or metabolic diseases, independent of the classical HLA genes. These alleles are part of the ancestral haplotype HLA 8.1 which includes HLA‐A*01 , ‐ B*08 , ‐ DR*03 , and ‐ DQ*02 . Family‐based studies analyzing HLA‐TNF extended haplotypes, which are known to be more effective than probabilistic approaches, as employed here, are required to corroborate our observations and for a better understanding of the HLA region variability in the Mexican population.…”

Section: Discussionsupporting

confidence: 52%

See 1 more Smart Citation

Tumor necrosis factor haplotype diversity in Mestizo and Native populations of Mexico

et al. 2014

View full text Add to dashboard Cite

The so-called tumor necrosis factor (TNF) block includes the TNFA, lymphotoxin alpha and beta (LTA and LTB) genes with single-nucleotide polymorphisms (SNP) and microsatellites with an allele frequency that exhibits interpopulation variability. To date, no reports have included both SNPs and microsatellites at the TNF block to study Mestizo or Amerindian populations from Mexico. In this study, samples of five Mexican Mestizo populations (Durango, Guadalajara, Monterrey, Puebla, and Tierra Blanca) and four native-Mexican populations (North Lacandonians, South Lacandonians, Tepehuanos, and Yaquis) were genotyped for two SNPs (LTA+252A>G and TNFA-308G>A) and four microsatellites (TNFa, d, e, and f), to analyze the genetic substructure of the Mexican population. Allele and haplotype frequencies, linkage disequilibrium (LD), and interpopulation genetic relationships were calculated. There was significant LD along almost all of the TNF block but the lowest D' values were observed for the TNFf-TNFd pair. Mestizos showed higher allele and haplotype diversity than did natives. The genetic differentiation level was reduced among Mestizos; however, a slightly, but significant genetic substructure was observed between northern and southern Mexican Mestizos. Among the Amerindian populations, the genetic differentiation level was significantly elevated, particularly in both North and South Lacandonians. Furthermore, among Southern Lacandonians, inhabitants of Lacanja town were the most differentiated from all the Mexicans analyzed. The data presented here will serve as a reference for further population and epidemiological studies including these TNF polymorphisms in the Mexican population.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 52%

Tumor necrosis factor haplotype diversity in Mestizo and Native populations of Mexico

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Although TNFa2 and TNFa9 alleles are positively associated with young-onset type 1 diabetic patients from Japan [32], no such association was observed among type 1 diabetic patients from Italy [60]. On the other hand, TNFa1 confers risk to T1D in the Belgian population [61].…”

Section: Discussionmentioning

confidence: 94%

Tumor necrosis factor–associated susceptibility to type 1 diabetes is caused by linkage disequilibrium with HLA-DR3 haplotypes

et al. 2012

View full text Add to dashboard Cite

“…The effects of the TNF 308 G/A polymorphism are so small that in the short period the difference can not be observed. In addition, interaction of the TNF gene with other pro- and anti- inflammatory cytokine genes plays an integrated role in destruction of pancreatic beta cells [36]. And cytokines in the circulation interact with each other in the pathogenesis of diabetes.…”

Section: Discussionmentioning

confidence: 99%

Meta-Analysis of TNF 308 G/A Polymorphism and Type 2 Diabetes Mellitus

et al. 2011

View full text Add to dashboard Cite

Background and ObjectivesMany investigations have focused the association between TNF 308 G/A polymorphism and risk for type 2 diabetes mellitus (T2DM). However, the sample sizes of most of the studies were small. The aim of this study is to evaluate the precise association between this variant and risk for T2DM in a large-scale meta-analysis.MethodsAll publications were searched on the association between TNF 308 G/A polymorphism and T2DM. The key words were as follows: diabetes, tumor necrosis factor and polymorphism/variant/genotype. This meta-analysis was assessed by Review manager 5.0.ResultsThere were 18 studies identified. The odd ritos (ORs) and 95% confidence intervals (CI) for GA+AA versus GG genotype of TNF 308 G/A polymorphism were 1.03 (0.95–1.12), 1.03 (0.94–1.13) and 1.03 (0.78–1.36) in overall, Caucasian and Asian populations, respectively. The sensitivity analysis further strengthened the validity of this association. No publication bias or heterogeneity was observed in this study.ConclusionIn summary, there was no significant association detected between the TNF 308 G/A polymorphism and risk for T2DM.

show abstract

TNFa microsatellite polymorphism modulates the risk of type 1 diabetes in the Belgian population, independent of HLA-DQ

Cited by 10 publications

References 51 publications

Tumor necrosis factor haplotype diversity in Mestizo and Native populations of Mexico

Tumor necrosis factor haplotype diversity in Mestizo and Native populations of Mexico

Tumor necrosis factor–associated susceptibility to type 1 diabetes is caused by linkage disequilibrium with HLA-DR3 haplotypes

Meta-Analysis of TNF 308 G/A Polymorphism and Type 2 Diabetes Mellitus

Contact Info

Product

Resources

About