TNFR1 Contributes to Activation-Induced Cell Death of Pathological CD4+ T Lymphocytes During Ischemic Heart Failure

Kumar, Vinay; Rosenzweig, Rachel; Asalla, Suman; Nehra, Sarita; Prabhu, Sumanth D.; Bansal, Shyam S.

doi:10.1016/j.jacbts.2022.05.005

Cited by 40 publications

(37 citation statements)

References 28 publications

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“…The four categories of cardiovascular disease, frequently referred as heart events, are as follows: Aortic atherosclerosis, cerebrovascular disease, peripheral artery disease, and coronary artery disease (CAD) [45][46][47]. Immune cells also play important role in heart failure, particularly to pathological CD4 + T-lymphocytes during ischemic heart failure and heart remodeling [48]. Humans practice fasting for various reasons including religious, ethical, health reasons etc.…”

Section: Ketogenic Diet Mediated Immune Regulation In Cardiovascular ...mentioning

confidence: 99%

Immune Modulatory Effects of Ketogenic Diet in Different Disease Conditions

Srivastava

Pawar

Tyagi

et al. 2022

Immuno

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Interceding nutrients have been acquiring increased attention and prominence in the field of healing and deterrence of various disorders. In this light, the present article encompasses several facets of ketogenic diet as an immunomodulator with respect to its expansive clinical applications. Accordingly, several scientific records, models, and case histories, including viral infections, cancer, chronic diseases, e.g., cardiovascular diseases, epilepsy, as well as numerous other neuro-disorders, are assembled, revealing a profound influence of KD in favor of improvement in the patient’s condition. We accentuate possible manifold mechanisms of KD that require further exploration.

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Section: Ketogenic Diet Mediated Immune Regulation In Cardiovascular ...mentioning

confidence: 99%

Immune Modulatory Effects of Ketogenic Diet in Different Disease Conditions

Srivastava

Pawar

Tyagi

et al. 2022

Immuno

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“…Inflammation plays a key role in the development of atherosclerosis and coronary artery disease [31]. Inflammation and immune cells CD4+ not only take part in cardiac injury [32,33], but also have an essential role in promoting cardiac homeostasis and injury repair, but these repair processes also increase "bystander damage" that overreact to injury [34]. In our study, we did not check any inflammation markers, but all the patients of the study received statin treatment for hyperlipidaemia.…”

Section: Discussionmentioning

confidence: 93%

Multivessel Coronary Disease and Severe Atherosclerotic Aorta: Real-World Experience

Gasparovic,

Artemiou,

Domonkos

et al. 2023

Medicina

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Background and Objectives: Surgical revascularisation of patients with atherosclerosis of the ascending aorta remains a challenge. Different surgical strategies have been described in coronary surgical patients to offer alternative revascularisation strategies other than the conventional surgical revascularisation in patients unsuitable for it. The aim of this study is to compare the real-world outcomes between two groups of patients who underwent off-pump surgery (left internal mammary artery graft to the left anterior descending artery) or a hybrid with a percutaneous revascularisation procedure at a later stage. Materials and Methods: This is a single-centre retrospective observational study. Between the years 2010 and 2021, 91/6863 patients (1.33%) were diagnosed with severe atherosclerosis of the ascending aorta. All the patients were treated with off-pump revascularisation (91 patients), and the cardiologist would decide at a later stage whether the rest of the vessels would be treated with percutaneous revascularisation (25 patients). Results: There was no statistical difference in the various preoperative characteristics, except for coronary artery left main disease (30.30% vs. 64%; p = 0.0043). The two groups had no statistical differences in the perioperative characteristics and postoperative complications. The 1-, 5-, and 10-year mortality rates in the two groups were 6.1% vs. 0%, 59% vs. 80%, and 93.9% vs. 100%, respectively (off-pump vs. hybrid with percutaneous revascularisation procedure, p = 0.1958). Conclusions: Both strategies have high long-term comparable mortality. The off-pump surgery and the HCR procedure at a later stage may be solutions for these high-risk patients, but the target treatment should be complete HCR revascularisation during the index hospitalization.

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“…In addition, recent studies indicate that immune cells significantly affect the development of HF. Immune cells such as cluster of differentiation 4 T cells or cluster of differentiation 8 T cells have potential impacts on the development or regulation of HF and cardiac remodeling in heart ischemia [ 27 , 28 , 29 , 30 , 31 ].…”

Section: The Interlink Connections Of Ascvd and Nafldmentioning

confidence: 99%

Association between Cardiovascular Disease and Liver Disease, from a Clinically Pragmatic Perspective as a Cardiologist

et al. 2023

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Cardiovascular diseases and liver diseases are closely related. Non-alcoholic fatty liver disease has the same risk factors as those for atherosclerotic cardiovascular disease and may also be a risk factor for atherosclerotic cardiovascular disease on its own. Heart failure causes liver fibrosis, and liver fibrosis results in worsened cardiac preload and congestion. Although some previous reports regard the association between cardiovascular diseases and liver disease, the management strategy for liver disease in patients with cardiovascular diseases is not still established. This review summarized the association between cardiovascular diseases and liver disease. In patients with non-alcoholic fatty liver disease, the degree of liver fibrosis progresses with worsening cardiovascular prognosis. In patients with heart failure, liver fibrosis could be a prognostic marker. Liver stiffness assessed with shear wave elastography, the fibrosis-4 index, and non-alcoholic fatty liver disease fibrosis score is associated with both liver fibrosis in patients with liver diseases and worse prognosis in patients with heart failure. With the current population ageing, the importance of management for cardiovascular diseases and liver disease has been increasing. However, whether management and interventions for liver disease improve the prognosis of cardiovascular diseases has not been fully understood. Future investigations are needed.

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TNFR1 Contributes to Activation-Induced Cell Death of Pathological CD4+ T Lymphocytes During Ischemic Heart Failure

Cited by 40 publications

References 28 publications

Immune Modulatory Effects of Ketogenic Diet in Different Disease Conditions

Immune Modulatory Effects of Ketogenic Diet in Different Disease Conditions

Multivessel Coronary Disease and Severe Atherosclerotic Aorta: Real-World Experience

Association between Cardiovascular Disease and Liver Disease, from a Clinically Pragmatic Perspective as a Cardiologist

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