TNFα and IL-1β mediate intercellular adhesion molecule-1 induction via microglia–astrocyte interaction in CNS radiation injury

Inhibition of the α-mannosidase Man2c1 gene expression enhances adhesion of Jurkat cells

“…For example, rise of the sICAM-1 level was observed in the serum of tumor patients during the period of IL-2 therapy [25]. Induction of ICAM-1 expression on epithelial cell [26], brain tissue [27] and blood smooth muscle [28] was found to be induced by IL-1 and TNF-a. Although IL-2, IL-1 and TNF-a genes were not up-regulated in AS cells, up-regulation of their receptors, i.e., IL-2gR, IL-1R and TNF receptor-associated Factor 5, were observed.…”

Microdissection and transcriptional profiling

“…The adhesion molecules ICAM1 and VCAM1 are typically expressed on endothelial cells and cells of the immune system, including microglia and astrocytes. 67 In this case, microdissection allows us to track the temporal expression of these adhesion molecules well before immune activation markers are detected, such as cytokines and chemokines. We also noted the increased expression of miR-146a-5p during clinical disease, which is not surprising as this miRNA is known to be expressed from activated microglia.…”

Standard of care therapy for malignant glioma and its effect on tumor and stromal cells

“…response by upregulating several cytokines, including TNFa, TNFb, IL-1a, IL-1b, IL-6 and Gro/KC (Kureshi et al, 1994;Kyrkanides et al, 1999;Kim et al, 2002;Hwang et al, 2006;Kalm et al, 2009). In astrocytes, radiation exposure can induce a proinflammatory response by increasing TNF production, which can enhance the antitumor effect (Chiang and McBride, 1991).…”