To compare the effect of two different doses of dexmedetomidine on the attenuation of airway and pressor response during tracheostomy tube change in traumatic brain injury patients

Khan, Abdul Alim; Kumar, Neeraj; Singh, Yashpal; Singh, Atul Kumar; Mathur, SK

doi:10.4103/aer.aer_103_17

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…For four studies, no impact factor of the publishing journal was listed [ 16 , 38 , 39 , 40 , 76 , 77 ]. Further, 11 articles were not available through the Web of Science database search at all [ 12 , 15 , 33 , 41 , 51 , 55 , 56 , 66 , 74 , 79 , 81 ]. Details on the studies, including specific interventions, number of patients and outcome measures, are attached as a Supplemental Data File .…”

Section: Resultsmentioning

confidence: 99%

A Retrospective Analysis of Randomized Controlled Trials on Traumatic Brain Injury: Evaluation of CONSORT Item Adherence

et al. 2021

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Traumatic brain injury (TBI) contributes to death and disability, resulting in an enormous individual and socio-economic challenges. Despite huge efforts, there are still controversies on treatment strategies and early outcome estimation. We evaluate current randomized controlled trials (RCTs) on TBI according to their fulfillment of the CONSORT (Consolidated Statement of Reporting Trials) statement’s criteria as a marker of transparency and the quality of study planning and realization. A PubMed search for RCTs on TBI (January 2014–December 2019) was carried out. After screening of the abstracts (n = 1.926), the suitable full text manuscripts (n = 72) were assessed for the fulfillment of the CONSORT criteria. The mean ratio of consort statement fulfillment was 59% (±13%), 31% of the included studies (n = 22) complied with less than 50% of the CONSORT criteria. Citation frequency was moderately related to ratio of CONSORT item fulfillment (r = 0.4877; p < 0.0001) and citation frequency per year (r = 0.5249; p < 0.0001). The ratio of CONSORT criteria fulfillment was associated with the impact factor of the publishing journal (r = 0.6428; p < 0.0001). Essential data for study interpretation, such as sample size determination (item 7a), participant flow (item 13a) as well as losses and exclusions (item 13b), were only reported in 53%, 60% and 63%, respectively. Reporting and methodological aspects in RCTs on TBI still may be improved. Thus, the interpretation of study results may be hampered due to methodological weaknesses.

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Section: Resultsmentioning

confidence: 99%

A Retrospective Analysis of Randomized Controlled Trials on Traumatic Brain Injury: Evaluation of CONSORT Item Adherence

et al. 2021

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“…In a meta-analysis of assessment of dexmedetomidine as an anesthetic agent by Piao and Wu,[ 21 ] the occurrence of adverse effects such as hypotension and bradycardia with dexmedetomidine was found to be significantly higher as compared to controls. Khan et al .,[ 22 ] in their comparative study of 1.0 μg/kg and 0.5 μg/kg doses of dexmedetomidine, reported a higher incidence of hypotension and bradycardia with the use of higher dose of the drug. In our study, the use of lower dose was associated with a lesser incidence of both these side effects.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic efficacy of two different doses of dexmedetomidine on the hemodynamic response to intubation, the intubating conditions, and the effect on the induction dose of propofol: A randomized, double-blind, placebo-controlled study

Sharma

Mehta

2018

Anesth Essays Res

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Context:The hemodynamic response associated with laryngoscopy and tracheal intubation is a common concern for the anesthesiologist, especially in high-risk patients. The use of dexmedetomidine has found favor in obtunding this response, in addition to providing better intubating conditions and reducing the dose of other anesthetic drugs. Most of the current literature states a loading dose of 1 μg/kg dexmedetomidine to be superior to lower doses in this regard. However, using a lower dose may be advantageous by reducing incidence of adverse effects such as hypotension and bradycardia which are likelier with the use of higher dose, in addition to being more cost-effective.Aims:The aim of the study was (1) to evaluate and compare the effect of loading doses of 1 μg/kg and 0.5 μg/kg dexmedetomidine on attenuation of hemodynamic response to laryngoscopy and intubation and (2) to evaluate the efficacy of dexmedetomidine in reducing the induction dose of propofol for achieving better intubating conditions.Materials and Methods:A randomized, double-blind, placebo-controlled study was planned on ninety American Society of Anesthesiologists I and II patients scheduled for elective surgery under general anesthesia. Patients were divided into three groups. Two groups received different loading doses of dexmedetomidine infusion before induction and the third group was a control group. The induction dose of propofol required to abolish the verbal response was noted and compared in all the three groups. All patients were assessed for the intubating conditions and hemodynamic response.Statistical Analysis:Nonparametric data were compared using the Chi-square test and parametric data were compared using Student's t-test using SPSS 16.0 software.Results:Both the loading doses of 1 μg/kg and 0.5 μg/kg dexmedetomidine were equally effective in reducing the induction dose of propofol, improving the intubating conditions and blunting the hemodynamic response to laryngoscopy and intubation. The incidence of adverse effects such as hypotension and bradycardia was lesser with the loading dose of 0.5 μg/kg.Conclusions:Dexmedetomidine when used as infusion in the loading dose of 0.5 μg/kg is therapeutically as effective as when used in the dose of 1.0 μg/kg not only in reducing the induction dose of propofol but also in providing good intubating conditions and blunting the hemodynamic response to intubation. A lower dose is associated with a lesser incidence of adverse effects such as hypotension and bradycardia.

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“…Khan et al . [ 27 ] in their comparative study of 1.0 μg/kg and 0.5 μg/kg doses of dexmedetomidine reported a higher incidence of hypotension and bradycardia with the use of higher dose of the drug. In our study, the use of lower dose was associated with a lesser incidence of both these side effects.…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of different doses of intravenous dexmedetomidine on hemodynamic response during laryngoscopy and endotracheal intubation in geriatric patients undergoing spine surgeries: A prospective, double-blind study

Keshri¹,

Prasad²,

Choudhary³

et al. 2018

Anesth Essays Res

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To compare the effect of two different doses of dexmedetomidine on the attenuation of airway and pressor response during tracheostomy tube change in traumatic brain injury patients

Cited by 6 publications

References 19 publications

A Retrospective Analysis of Randomized Controlled Trials on Traumatic Brain Injury: Evaluation of CONSORT Item Adherence

A Retrospective Analysis of Randomized Controlled Trials on Traumatic Brain Injury: Evaluation of CONSORT Item Adherence

Therapeutic efficacy of two different doses of dexmedetomidine on the hemodynamic response to intubation, the intubating conditions, and the effect on the induction dose of propofol: A randomized, double-blind, placebo-controlled study

Comparative evaluation of different doses of intravenous dexmedetomidine on hemodynamic response during laryngoscopy and endotracheal intubation in geriatric patients undergoing spine surgeries: A prospective, double-blind study

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