“To define is to limit”: perspectives on asthma–COPD overlap syndrome and personalised medicine

McDonald, Vanessa M.; Gibson, Peter G.

doi:10.1183/13993003.00336-2017

Cited by 8 publications

(5 citation statements)

References 26 publications

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“…Fixed airflow obstruction is a common feature of severe asthma, and it may be impossible to differentiate severe asthma from COPD, in patients with a significant smoking history [65]. Additionally, a significant proportion of severe asthma starts in adulthood, and adult onset asthma in general is associated with low lung function: As many as 46% of adults with asthma onset after the age of 65 years have an FEV1 < 80% prior to being diagnosed with asthma [66].…”

Section: Systematic Assessment Of Severe Asthmamentioning

confidence: 99%

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Porsbjerg

Ulrik

Skjold

et al. 2018

European Clinical Respiratory Journal

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Although a minority of asthma patients suffer from severe asthma, they represent a major clinical challenge in terms of poor symptom control despite high-dose treatment, risk of exacerbations, and side effects. Novel biological treatments may benefit patients with severe asthma, but are expensive, and are only effective in appropriately targeted patients. In some patients, symptoms are driven by other factors than asthma, and all patients with suspected severe asthma (‘difficult asthma’) should undergo systematic assessment, in order to differentiate between true severe asthma, and ‘difficult-to-treat’ patients, in whom poor control is related to factors such as poor adherence or co-morbidities. The Nordic Consensus Statement on severe asthma was developed by the Nordic Severe Asthma Network, consisting of members from Norway, Sweden, Finland, Denmark, Iceland and Estonia, including representatives from the respective national respiratory scientific societies with the aim to provide an overview and recommendations regarding the diagnosis, systematic assessment and management of severe asthma. Furthermore, the Consensus Statement proposes recommendations for the organization of severe asthma management in primary, secondary, and tertiary care.

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Section: Systematic Assessment Of Severe Asthmamentioning

confidence: 99%

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Porsbjerg

Ulrik

Skjold

et al. 2018

European Clinical Respiratory Journal

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“…They are usually distinct disorders but approximately 20% of patients with obstructive lung disease will have features of both conditions. 1,2 Asthma-COPD overlap is a term sometimes used to refer to this group of patients, but consensus on a precise definition is lacking. 2 Contributing to the controversy around a definition is the heterogeneity of clinical manifestations within this group and the relative importance of each disorder in an individual.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Asthma-COPD overlap is a term sometimes used to refer to this group of patients, but consensus on a precise definition is lacking. 2 Contributing to the controversy around a definition is the heterogeneity of clinical manifestations within this group and the relative importance of each disorder in an individual. 3 COPD is characterised by persistent respiratory symptoms and airflow limitation, due to a combination of small airways disease and parenchymal destruction (i.e.…”

Section: Introductionmentioning

confidence: 99%

Managing the overlap of asthma and chronic obstructive pulmonary disease

Knight¹

2020

Aust Prescr

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Approximately 20% of patients with obstructive lung disease have features of both asthma and chronic obstructive pulmonary disease.These patients have a higher burden of disease and increased exacerbations compared to those with asthma or chronic obstructive pulmonary disease alone.Management should address dominant clinical features in each individual patient, and comorbidities should be considered.There are several interventions that are useful in the management of both asthma and chronic obstructive pulmonary disease.As inhaled corticosteroids are key to the management of asthma, they are recommended in patients with overlapping chronic obstructive pulmonary disease.

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“…However, although misdiagnosis between the asthma and COPD is common, they may coexist in what is known as asthma-COPD overlap syndrome (ACOS) [207], although whether this should be considered a distinct third entity is under active debate [208][209][210][211]. Many other respiratory conditions can mimic asthma.…”

Section: Interpretation In the Light Of Previous Studiesmentioning

confidence: 99%

“…Instead, Agusti et al have suggested a label-free precision medicine strategy for chronic lung diseases in which treatable traits, rather than encompassing labels such as asthma and COPD, form the basis for diagnosis and management [406]. This contemporary clinical perspective has been epitomised in a recent editorial with Oscar Wilde's quote "to define is to limit" [208].…”

Section: Supporting Research Reproducibilitymentioning

confidence: 99%

Creating and utilising the Wales Asthma Observatory to support health policy, health service planning and clinical research

Sallakh¹,

Mohammad²

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“To define is to limit”: perspectives on asthma–COPD overlap syndrome and personalised medicine

Cited by 8 publications

References 26 publications

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Managing the overlap of asthma and chronic obstructive pulmonary disease

Creating and utilising the Wales Asthma Observatory to support health policy, health service planning and clinical research

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