To determine the correlation between mean platelet count and frequency of grading of esophageal varices in patients of liver cirrhosis.

Javed, Muhammad Awais; Mohammad, Dilshad; Masood, Zain; Sheikh, Ghulam Abbas; Iftikhar, Muzammal; Hamed, Afaira

doi:10.29309/tpmj/2021.28.06.6258

Cited by 2 publications

(5 citation statements)

References 21 publications

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“…Literature review revealed that in the severe state of liver cirrhosis there is hemostatic disturbance specifically thrombocytopenia has been noted in which platelet count is less than 150,000/ul so testing platelet count can be a predictor of liver cirrhosis developed complications like esophageal varices (17). Literature review revealed that there is a strong association between the low platelet count and development of esophageal varices (18). Current study also found a strong significant association between the platelet count and presence of esophageal varices.…”

Section: Discussionsupporting

confidence: 64%

Association Between Platelet Count and Grading of Esophageal Varices in Patients with Liver Cirrhosis

Mahmood¹,

Khan²,

Memon³

et al. 2023

PJMHS

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Background: Upper GI endoscopy is the gold standard technique for diagnosing esophageal varices and to assess the risk of bleeding but is invasive in nature, costly, time consuming and burden for the department. Besides this platelet count is also an important tool to predict the esophageal varices in cirrhotic patient and it is a highly accurate test. it has been noted that platelet count in cirrhotic patients with esophageal varices, is less than 100,000/cmm but very few of the data is available so the aim of the current study was to find out the association between mean platelet count and grading of esophageal varices in patients with liver cirrhosis. Methods: A descriptive cross-sectional study was conducted at the medicine department of Jinnah Postgraduate Medical Center (JPMC), Karachi. For testing platelet count the blood sample was sent to the pathology laboratory of the hospital. Gastroenterologist performed the upper gastrointestinal endoscopy to grade the esophageal varices. Data was analyzed by using the Statistical Package for Social Science (SPSS) version-20. ANOVA with Post-Hoc Tuckey test was applied to find out the correlation between the variables. p-value less than 0.05 was considered as significant. Results: The mean age of the study participants was 34.9±8.6 years. Majority of the study participants were male (61.1%) as compared to their counterparts. The mean platelet count among the study participants was 113,200±29000 /u L majority of cirrhotic patients included in the study were having grade III of esophageal varices (39.5%). It has been noted that mean platelet count decreased with increasing grade of esophageal varices and the association was significant. Cirrhotic patients having Grade I esophageal varices were having near normal mean platelet count but those who were in Grade V of esophageal varices, having markedly decreased platelet count as compared to Grade I, II, III and IV. Conclusion: It can be concluded that the mean platelet count is significantly inverse association with the grading of esophageal varices, as low as the platelet count, worst the esophageal varices in patients with liver cirrhosis. So testing mean platelet count can be used for screening purpose of esophageal varices as it is a cost effective test. Keywords: Cirrhosis, Esophageal varices, Mean Platelet count,

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Section: Discussionsupporting

confidence: 64%

Association Between Platelet Count and Grading of Esophageal Varices in Patients with Liver Cirrhosis

Mahmood¹,

Khan²,

Memon³

et al. 2023

PJMHS

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“…This meta-analysis included eight articles comprising 1008 patients. Among these studies, one study was conducted in China [12], two studies were conducted in Egypt [20], [21], one study was conducted in India [26], three studies were conducted in Pakistan [10], [19], [27], [28], and one study was conducted in Singapore [28]. Three studies were prospective observational [12], [20], [21] and five were cross-sectional [10], [19], [27], [28], [29].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…From eight studies consisting of 1008 patients, seven studies reported a negative correlation between platelet count and grading of esophageal varices in liver cirrhosis patients [12], [19], [20], [21], [27], [28], [29], while one study reported a positive correlation coefficient [10]. A meta-analysis was done on eight eligible studies, the result of the forest plot showed that there is a significant moderate negative correlation between platelet count and grading of esophageal varices in liver cirrhosis patients, with a pooled correlation coefficient (r) of -0.42 (95%CI -0.65 to -0.13; p = 0.005) (Figure 2).…”

Section: Platelet Count and Grading Of Esophageal Varicesmentioning

confidence: 99%

“…Esophageal varices bleeding is often life-threatening and associated with high mortality rates. Esophageal varices bleeding had mortality rates of 15% for overall 30-day mortality and 20-70% for one-year mortality [9], [10]. The rate of development of esophageal varices raises approximately 5% per year, and evolvement from small to large varices is about 5-10% per year [11].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, many studies have investigated the correlation between platelet count and esophageal varices. However, the result seemed inconsistent, and some studies showed a negative correlation between platelet count and grading of esophageal varices [20], [21], while other studies showed a positive correlation [10]. The differences in these results potentially lead to being inconsistent conclusions.…”

Section: Introductionmentioning

confidence: 99%

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Correlation between Platelet Count and Grading of Esophageal Varices in Liver Cirrhosis Patients: A Meta-Analysis

Baihaqi

Delarosa²

2022

Open Access Maced J Med Sci

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BACKGROUND: Esophageal varices are a major complication of liver cirrhosis. Esophageal varices bleeding is life-threatening and an urgent medical emergency. Low platelet count and esophageal varices are common findings in liver cirrhosis. Platelet count is suggested as a non-invasive screening tool to predict the grading of esophageal varices in liver cirrhosis patients. Several studies have found a correlation between platelet count and grading of esophageal varices in liver cirrhosis patients. However, the results are conflicting. AIM: This meta-analysis aimed to evaluate the correlation between platelet count and the grading of esophageal varices in liver cirrhosis patients. METHODS: A systematic literature search was performed through the database search from PubMed, SCOPUS, Ovid EMBASE, and EuropePMC to obtain all relevant articles with the following search terms: "correlation" and "platelet" or "thrombocytopenia" AND "esophageal varices" and "liver cirrhosis" or "chronic liver disease" that were published within the year of 2000-2021. Articles were collected by using PRISMA flow diagrams. The data were extracted from the eligible study within inclusion and exclusion criteria. The quality of each study was assessed using the Newcastle Ottawa Scale (NOS). A meta-analysis was conducted to determine the overall pooled correlation coefficient (r) and 95% confidence interval (CI). RESULTS: There were a total of 1008 patients from eight included studies. The meta-analysis showed that the pooled correlation coefficient between platelet count and grading of esophageal varices in liver cirrhosis patients was r = -0.42 (95%CI -0.65 to -0.13; p = 0.005; I2 = 96.06%). CONCLUSION: There was a moderate negative correlation between platelet count and grading of esophageal varices. Thus, low platelet count may indicate higher grades of esophageal varices in liver cirrhosis patients.

show abstract

To determine the correlation between mean platelet count and frequency of grading of esophageal varices in patients of liver cirrhosis.

Cited by 2 publications

References 21 publications

Association Between Platelet Count and Grading of Esophageal Varices in Patients with Liver Cirrhosis

Association Between Platelet Count and Grading of Esophageal Varices in Patients with Liver Cirrhosis

Correlation between Platelet Count and Grading of Esophageal Varices in Liver Cirrhosis Patients: A Meta-Analysis

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