To Evaluate the Safety and Efficacy of Amlodipine and Chlorthalidone in Combination With Telmisartan in Hypertensive Patients Attending Tertiary Care Centre, Telangana

Abstract

Objective: The main objective of this study is to evaluate and compare the effects of both treatments on systolic and diastolic blood pressure in 4th, and 8th weeks with baseline Methods: A prospective, comparative, Open-label, and parallel-group clinical study was conducted in out patient's department of general medicine at Osmania general hospital. 120 patients were randomly allocated into 2 groups. Group 1 with 60 patients received Tab: Telmisartan 40 mg+Amlodipine 5 mg once daily, and Group 2 with 60 patients received Tab: Telmisartan 40 mg+ Chlorthalidone 6.25 mg once daily for a period of 8 w. Follow-up was done in the 4th week and 8th week to evaluate the safety and efficacy in hypertensive patients. Results: The differences in the SBP, DBP, and HR in group A (P value<0.001) and group B (P value<0.001) at the 4th week and 8th week follow-up periods with baseline value (0 w) were statistically significant as P value<0.05. Conclusion: The combination of telmisartan plus amlodipine is equally effective as the combination of telmisartan plus chlorthalidone in decreasing SBP, DBP, HR, and MAP. No major adverse drug reactions were noted during the study period.

Perception of the general population on Epilepsy and Antiepileptic drugs: A questionnaire-based study

“…According to Sharma et al, integrating spiritual healing traditions and medical practitioners at the local level may aid in early referral and the beginning of appropriate therapy 31 .Most of our surveyees believed in surgical treatment for epilepsy, similar to a work by Santhosh NS 7 . Nonetheless, in other investigations, the majority were unaware of the same 13,18,27,30 .…”

“…Our EP/CG had good KAP related to the right dose, brand, and withdrawal of the therapy and its consequences, akin to a study by Shaju et al 17,26 .Analogous to our finding, 58.7% of science graduates in Karnataka agreed on the lifethreatening aspects of discontinuing AEDs, but contrary to our study, 59.3% believed AED discontinuation was impos-sible even after a three-year seizure-free interval 12 .This lack of cognizance could be attributed to non-epileptic population involved in that study. Similar to previous explorations, our subjects also maintained a seizure diary and adhered to the doctor's advice (reminders) to avoid missing doses 18,19 .Our study identified positive awareness and attitudes towards TDM, but in a Kochi-based survey, most individuals were ignorant 17 .Half of the answerers felt AEDs were safe during pregnancy, similar to a review that has stated the need for individualizing the therapy based on the risk and benefit 36 .On the whole, the KAP of EP/CG was better than that of nonepileptic individuals, in line with other studies 2,19 .…”

“…Epilepsy is a chronic disorder of brain function characterized by the recurrent and unpredictable occurrence of seizures 1 .Around 1% of the world's population has epilepsy, which is the fourth most common neurologic disorder after migraine, stroke, and Alzheimer's disease 1 .The annual incidence of epilepsy in India is approximately 40 to 50 per 100,000 per year, and the disease burden is higher (80%) in developing countries 2 .Epilepsy significantly impacts the medical, psychological, economic, and social aspects of the affected individuals, their families, and the community 3,4 .Studies have shown that, despite advancements in educational and social parameters, including technology and communication, there has been no significant change in the deep-rooted stigmas, perceptions, and discrimination of epilepsy throughout India and other developing countries compared to the developed countries [4][5][6] .There is also a noteworthy treatment gap among epilepsy patients due to this lack of cognizance 2,7,8 . Improving disease awareness and comprehension can aid in epilepsy prevention and treatment 2 .Hence, understanding the public's perception, attitudes, and practices regarding epilepsy and antiepileptic drugs (AEDs) is critical, as misconceptions about the disease have a negative impact on sufferers' quality of life (QOL) 9 .Though there are some original research articles on this topic from different states of India, because of the differences in the population investigated as well as the questionnaires and procedures utilized, the results are not strictly comparable 2,5,6,8,[10][11][12][13][14][15][16][17][18][19] . Except for a few Knowledge, Attitude, and Practice (KAP) studies in rural northeastern Tamil Nadu (TN), explorations targeting the non-epileptic general population of TN are very limited; hence, this research may help to assess the extent of the problem and provide additional insight into public KAP 5,10 .…”

Preparation, Characterisation, Evaluation and DFT Analysis of Cilnidipine-L-Phenylalanine Cocrystal

“…Uncontrolled hypertension is a significant risk factor for cardiovascular, renal and endocrine disorders. Long-acting dihydropyridine calcium channel blockers (CCBs) are used as firstline agents for hypertension, either as a monotherapy or in combination with other antihypertensive agents [11,12]. Cilnidipine is a unique and effective 1, 4 dihydropyridine CCB, which blocks both L and N-type calcium channels.…”