To prescribe, or not to prescribe: decision making in HIV‐1 post‐exposure prophylaxis

Mf, Scholten; Suárez, Isabelle; Platten, Martin; Kümmerle, Tim; Jung, Norma; Wyen, C.; Ernst, Angela; Horn, Carola; Burst, Volker; Suárez, Víctor; Rybniker, Jan; Fätkenheuer, Gerd; Lehmann, Clara

doi:10.1111/hiv.12645

Cited by 6 publications

(1 citation statement)

References 25 publications

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“…Scholten et al evaluated decisions on HIV-PEP in an infectious diseases clinic (IDC) in Cologne, Germany. 27 Importantly, patients who visited the ED and who were not subsequently referred to the IDC were explicitly excluded from the analysis of guideline concordance of HIV-PEP prescriptions in the Scholten et al study. 27 Meaningful comparisons with our report can therefore not be drawn.…”

Section: Discussionmentioning

confidence: 99%

Concordance of emergency department physicians’ decisions on HIV post-exposure prophylaxis with national guidelines: results from a retrospective cohort study

Heck,

Höner zu Siederdissen,

Krause

et al. 2023

International Health

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Background Post-exposure prophylaxis (PEP) is an effective tool to prevent infection with HIV. Patients seeking PEP after potential HIV exposure usually present to the emergency department (ED). Our study sought to determine the concordance of ED physicians’ decisions on HIV-PEP with national guidelines (primary objective) and to assess the clinical relevance of drug–drug interactions (DDIs) between the HIV-PEP regimen and patients’ concomitant medication (secondary objective). Methods We conducted a retrospective cohort study at the ED of Hannover Medical School, Germany. Between 1 January 2018 and 31 December 2019, 113 of 11 246 screened patients presented to the ED after potential HIV exposure and were enrolled in the study. Results The median age of the patients (82.3% male) was 30 y (IQR 25–35.5), 85.8% of potential HIV exposures were characterised as sexual and 85.0% presented within 72 h. ED physicians’ decisions on HIV-PEP were concordant with national guidelines in 93.8%. No clinically relevant DDIs were detected. Conclusions ED physicians’ decisions on HIV-PEP were highly concordant with national guidelines. Approximately 1% of patient presentations to the ED were related to HIV exposure; therefore, training ED physicians on HIV transmission risk assessment and indications/contraindications for HIV-PEP is paramount.

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Section: Discussionmentioning

confidence: 99%

Concordance of emergency department physicians’ decisions on HIV post-exposure prophylaxis with national guidelines: results from a retrospective cohort study

Heck,

Höner zu Siederdissen,

Krause

et al. 2023

International Health

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show abstract

New strategies for HIV prevention for men who have sex with men (MSM): pre-exposure prophylaxis (PrEP) and an ethical evaluation of its potential and its problems

2020

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Assessment of HIV-postexposure prophylaxis prescription quality after a training programme and assistance in decisions provided by a computer-based decision program: a cross-over study

Casalino

Bouzid

Antoniol

et al. 2021

Acta Clinica Belgica

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To prescribe, or not to prescribe: decision making in HIV‐1 post‐exposure prophylaxis

Abstract: PEP prescriptions are increasing and decision making is influenced by patients' emotional stress, but PEP prescriptions should be strictly administered according to risk assessment.

Cited by 6 publications

References 25 publications

Concordance of emergency department physicians’ decisions on HIV post-exposure prophylaxis with national guidelines: results from a retrospective cohort study

Concordance of emergency department physicians’ decisions on HIV post-exposure prophylaxis with national guidelines: results from a retrospective cohort study

New strategies for HIV prevention for men who have sex with men (MSM): pre-exposure prophylaxis (PrEP) and an ethical evaluation of its potential and its problems

Assessment of HIV-postexposure prophylaxis prescription quality after a training programme and assistance in decisions provided by a computer-based decision program: a cross-over study

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