Background: The human immunodeficiency virus (HIV), a lentivirus, subgroup of retrovirus causes HIV infection and over time acquired immunodeficiency syndrome (AIDS). Objective was to study socio demographic and clinical profile of people living with HIV/AIDS (PLHIV) registered at ART centre of Government Medical College, Nagpur.Methods: The present was cross sectional record based among the people living with HIV/AIDS registered from 1st January 2011 to 31st December 2013 at ART centre of the hospital.Results: There were total 2042 PLHIV subjects with Majority of subjects 37.76% were in age group 35-44 years with 80.26% were from urban area. Almost 46.34% study subjects were educated up to secondary class. Maximum subjects 38.29% belonged to IV socioeconomic class. The sexual mode of transmission being most common mode of transmission with 79.97 % subjects possibly acquiring infection through heterosexual route. About, 24.94% study subjects had opportunistic infections, out of that tuberculosis being was the most common opportunistic infection in 67.48% of study subjects. About 42.12% of the deaths of subjects were registered in year 2011.Conclusions: The study found that most of the subjects were from age group 15 to 54 years and sexual route being the commonest possible mode of transmission. Tuberculosis was the most common opportunistic infection. Deaths were reported more in the year 2011 as compare to 2012 and 2013.