To study the effect of ‘Covishield’ vaccination on pre-donation platelet counts of plateletpheresis donors

Tomar, Akshaya; Biswas, Amit K.; Pawar, Amit; Dimri, Ujjwal; Kumar, Deepak; Baranwal, Ajay Kumar

doi:10.1016/j.htct.2022.08.008

Cited by 1 publication

(1 citation statement)

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“…Recombinant adenoviral vectors have been documented to cause thrombocytopenia in vivo as well (114,115). In fact, a study by one of the largest government-owned transfusion centers in India showed significant deferral rates for plateletpheresis donors who had received one or two doses of ChAdOx1 nCoV-19 due to significantly lower platelet counts compared to controls (116). A study by Nicolai et al showed that IV, but not IM delivery of ChAdOx1 nCov-19 into mice led to thrombocytopenia (117).…”

Section: Adenovirus Vector As a Potential Polyanionmentioning

confidence: 99%

Vaccine-induced immune thrombotic thrombocytopenia: what do we know hitherto?

Roytenberg

Garcı́a-Sastre

2023

Front. Med.

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Vaccine-induced immune thrombotic thrombocytopenia (VITT), also known as thrombosis with thrombocytopenia syndrome, is a catastrophic and life-threatening reaction to coronavirus disease 2019 (COVID-19) vaccines, which occurs disproportionately in response to vaccination with non-replicating adenovirus vector (AV) vaccines. The mechanism of VITT is not well defined and it has not been resolved why cases of VITT are predominated by vaccination with AV vaccines. However, virtually all VITT patients have positive platelet-activating anti-platelet factor 4 (PF4) antibody titers. Subsequently, platelets are activated and depleted in an Fcγ-receptor IIa (FcγRIIa or CD32a)-dependent manner, but it is not clear why or how the anti-PF4 response is mounted. This review describes the pathogenesis of VITT and provides insight into possible mechanisms that prompt the formation of a PF4/polyanion complex, which drives VITT pathology, as an amalgam of current experimental data or hypotheses.

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