To what extent does depression influence quality of life of people with pharmacoresistant epilepsy in Argentina?

Scévola, Laura; Sarudiansky, Mercedes; Lanzillotti, Alejandra Inés; Oddo, Silvia; Kochen, Silvia; D’Alessio, Luciana

doi:10.1016/j.yebeh.2017.01.007

Cited by 34 publications

(22 citation statements)

References 39 publications

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“…Instead, psychiatric comorbidities, secondary effects of medication, or the sense of lack of control over their own lives could have more significant effects on their quality of life [6][7][8][9]. In a previous report published by our research team, significant differences regarding the patients' perspectives about their quality of life and the physician's assessment of their general functioning were found [3]. Some authors argue that if physicians fail to consider patients' perspectives, the doctor-patient relationship could be affected [10], and treatment compliance may be at risk [11].…”

Section: Introductionmentioning

confidence: 90%

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A life with seizures: Argentine patients’ perspectives about the impact of drug-resistant epilepsy on their lives

Sarudiansky

Korman

Scévola

et al. 2018

Seizure

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A B S T R A C TPurpose: To understand the experience of drug-resistant epilepsy in patients from Argentina, a developing nation. Method: A qualitative approach using semi-structured interviews was used to gain an in-depth and contextual understanding of the perspectives of 20 patients with DRE. Data collection and analysis were followed by an inductive and interpretive approach informed by the principles of thematic analysis. Results: Six main themes emerged: 1) Characteristics of the illness, including seizure features -unpredictability, presence of auras, physical and cognitive consequences-and how patients relate with the use of antiepileptic drugs; 2) interactions with health system, regarding the features of the Argentine's health system, and patient's health-seeking behaviours; 3) beliefs about the illness, including psychosocial, biological and folk explanatory models; 4) beliefs about how other people perceive them, which included prejudice, responsibility and overprotection; 5) self-perception, and 6) impact of the illness on their activities. Conclusions: This information might be useful to help in the development of a conceptual model of the impact epilepsy on patients' lives. Many of the topics mentioned as relevant in Argentina coincide with those highlighted in studies that were carried out in first-world countries. However, additional topics were also reported including the role of traditional healing in health-seeking behaviour and explanatory models of illness. It is important to understand these perspectives to develop appropriate psychosocial interventions for this specific population.

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Section: Introductionmentioning

confidence: 90%

“…Approximately one-third of people with epilepsy (PWE) do not respond satisfactorily to antiepileptic drugs. When more than two combinations of antiepileptic drugs have been tried without satisfactory response, patients are considered to have drug-resistant epilepsy (DRE), which has a significant impact on their lives [2,3].…”

Section: Introductionmentioning

confidence: 99%

A life with seizures: Argentine patients’ perspectives about the impact of drug-resistant epilepsy on their lives

Sarudiansky

Korman

Scévola

et al. 2018

Seizure

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“…It is, therefore, not a surprising issue that patients exhibit all of these together. About 55% lifetime prevalence for depression was found in epileptic patients which was tend to be high and that with temporal lobe epilepsy is estimated as 35% [2]. Depression directly increases seizure frequency through sleep deprivation.…”

Section: Introductionmentioning

confidence: 99%

“…People with epilepsy (PWE) will experience depression at a higher rate, mainly two-three fold when compared to a general population [4]. Depression is the psychiatric comorbidity which is seen more frequently in patients with epilepsy [2]. PWE and comorbid depression have reported lower quality of life [2].…”

Section: Introductionmentioning

confidence: 99%

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A Comprehensive Review on Comorbid Depression in Patients With Epilepsy

Mammen

Kumar

2017

Asian J Pharm Clin Res

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Epilepsy is one of the common neurological disorders that are seen worldwide. It can also affect a person's social, mental, and physiological well-being and thus restricts and disables the common living of man. Depression as such has been well reported in patients with epilepsy, and also depression itself remains a factor that can lead to the development of epilepsy. Increased rates of suicidal tendencies are also associated with depression both in men and women. Depression is further extended in affecting the quality of life in epileptic patients. Depressive rates are found to have a higher value in epileptic patients when compared with the normal population. This article aims to produce a comprehensive review of the epidemiological considerations, clinical findings and management strategies for depression associated with epilepsy.

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Determinants of health‐related quality of life of patients with focal epilepsy: A systematic literature review

Engelhart,

Marcin,

Lerner

et al. 2024

Epileptic Disorders

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ObjectiveFocal epilepsy can have significant negative impacts on a person's health‐related quality of life (HRQoL). Although studies have been published on HRQoL in persons with focal epilepsy (PWFE), determinants of HRQoL have not been comprehensively examined. This systematic literature review (SLR) queried existing literature to identify aspects associated with HRQoL in PWFE without focus on resective epilepsy surgery, with an interest in identifying modifiable determinants for medical/nonmedical interventions.MethodsThis SLR was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. Searches were conducted in PubMed and Google Scholar for articles published from January 1, 1900, to February 19, 2023, reporting on the association between HRQoL or employability and a range of demographic, psychosocial, or epilepsy‐related factors and comorbidities in PWFE.ResultsA total of 879 abstracts were identified, with 126 manuscripts reviewed and 37 studies selected for inclusion that quantified the relationship between HRQoL and the variable of interest by multivariate (N = 21) or univariate only (N = 15) methods; 10 multivariate models also included univariate data. In adjusted models, the most commonly examined determinants of HRQoL included depression (n = 15/21), number of antiseizure medications (ASMs; n = 13/21), seizure frequency (continuous seizure count, n = 11/21; seizure freedom, n = 5/21), anxiety (n = 10/21), duration of disease (n = 9/21), and cognition (n = 9/21). Depression, anxiety, and cognition were frequently seen as significant contributors to HRQoL when studied (14/15 [93%], 9/10 [90%], and 7/9 [78%], respectively). Among concepts studied less frequently, ASM severity/adverse event burden was significant each time examined (in 5/19 studies). Attainment of seizure freedom and employability was significant 75% (n = 3/4) and 72% (n = 5/7) of the time, respectively.SignificancePoor HRQoL in PWFE can be attributed to a multitude of factors, including depression, anxiety, factors in disease management, and employability. An unmet need remains in addressing elements associated with poor HRQoL in this population.

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To what extent does depression influence quality of life of people with pharmacoresistant epilepsy in Argentina?

Cited by 34 publications

References 39 publications

A life with seizures: Argentine patients’ perspectives about the impact of drug-resistant epilepsy on their lives

A life with seizures: Argentine patients’ perspectives about the impact of drug-resistant epilepsy on their lives

A Comprehensive Review on Comorbid Depression in Patients With Epilepsy

Determinants of health‐related quality of life of patients with focal epilepsy: A systematic literature review

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