Tobramycin/dexamethasone

Abstract

S Tobramycin/dexamethasone Ocular hypertension with decreased corneal hysteresis: case reportA 62-year-old man developed ocular hypertension with decreased corneal hysteresis (CH) while receiving tobramycin/ dexamethasone [Tobradex].The man had a history of osteoarthritis, hyperlipidaemia, hypertension and compound hyperopic astigmatism with presbyopia. He reported mattering of his eyes in the morning, and he was diagnosed with rosaceous meibomitis. He started receiving treatment with warm soaks and topical tobramycin/ dexamethasone ointment applied to his lids at night [dose not stated]. He later returned to the clinic [time to reaction onset not stated]. The following ocular response analyser (ORA) readings were found: OD intraocular pressure (IOP)/cc 32.4, IOP/g 28.1 and CH 5.2, and OS IOP/cc 40.7, IOP/g 36.7 and CH 6.0. His IOP had increased 76% and 124% in his right and left eyes, respectively. His CH had decreased 41% in his right eye and 30% in his left eye. He was diagnosed with corticosteroid ocular hypertension.Tobramycin/dexamethasone was withdrawn. One month later, his IOPs had decreased and his CH reading had increased. At last follow-up, the following ORA readings were found: OD IOP/cc 17.9, IOP/g 15.4 and CH 8.7, and OS IOP/ cc 18.9, IOP/g 16.7 and CH 8.6.Author comment: "The patient then developed bilateral increased IOP coupled with decreased corneal stiffness detected by the [ocular response analyser] as a consequence of the topical treatment provided." Molinari JF. Decrease corneal hysteresis in steroid-induced ocular hypertension: a case report. Military Medicine 178: e862-e864, No. 7,