Togaviridae

Staples, J. Erin; Powers, Ann M.

doi:10.1016/b978-0-323-75608-2.00217-2

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Clinical Manifestation and Pathogenicity1

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2024

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“…Once bitten by an infected mosquito, ONNV generally has an incubation period of 8 days before symptoms start to manifest ( Figure 4 ) [ 92 ]. Infections by ONNV are typically self-limiting and present with fever, rash, distinctive muscle and debilitating joint pain that can result in polyarthralgia.…”

Section: Clinical Manifestation and Pathogenicitymentioning

confidence: 99%

Pathogenicity and virulence of O’nyong-nyong virus: A less studied Togaviridae with pandemic potential

Tong Jia Ming,

Tan Yi Jun,

Carissimo

2024

Virulence

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O’nyong-nyong virus (ONNV) is a neglected mosquito-borne alphavirus belonging to the Togaviridae family. ONNV is known to be responsible for sporadic outbreaks of acute febrile disease and polyarthralgia in Africa. As climate change increases the geographical range of known and potential new vectors, recent data indicate a possibility for ONNV to spread outside of the African continent and grow into a greater public health concern. In this review, we summarise the current knowledge on ONNV epidemiology, host–pathogen interactions, vector-virus responses, and insights into possible avenues to control risk of further epidemics. In this review, the limited ONNV literature is compared and correlated to other findings on mainly Old World alphaviruses. We highlight and discuss studies that investigate viral and host factors that determine viral-vector specificity, along with important mechanisms that determine severity and disease outcome of ONNV infection.

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Section: Clinical Manifestation and Pathogenicitymentioning

confidence: 99%