Togavirus Morphology and Morphogenesis

Murphy, Frederick A.

doi:10.1016/b978-0-12-625380-1.50013-8

Cited by 60 publications

(59 citation statements)

References 133 publications

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“…Their cores are 25-30 nm in diameter. Along the outer surface of the virion envelope are projections that are 5-10 nm long with terminal knobs 2 nm in diameter (Murphy, 1980).…”

Section: A Morphologymentioning

confidence: 99%

Replication of Flaviviruses

Brinton

1986

The Togaviridae and Flaviviridae

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“…Their cores are 25-30 nm in diameter. Along the outer surface of the virion envelope are projections that are 5-10 nm long with terminal knobs 2 nm in diameter (Murphy, 1980).…”

Section: A Morphologymentioning

confidence: 99%

Replication of Flaviviruses

Brinton

1986

The Togaviridae and Flaviviridae

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“…The EAV virion has a diameter of 50-70 nm (Hyllseth, 1973) and consists of an isometric nucleocapsid (35 nm) surrounded by an envelope which carries ring-like surface structures with a diameter of 12-15 nm (Murphy, 1980;Horzinek, 1981). The nucleocapsid is composed of an infectious, polyadenylated, single-stranded genomic RNA with a size of 12.7 kb (den Boon et al, 1991) and phosphorylated core protein (N) with a molecular mass * Author for correspondence.…”

Section: Introductionmentioning

confidence: 99%

Equine arteritis virus-neutralizing antibody in the horse is induced by a determinant on the large envelope glycoprotein GL

Chirnside

Vries

Mumford

et al. 1995

Journal of General Virology

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Complementary DNAs encoding ORFs 2 to 7 of equine arteritis virus (EAV) have been cloned into the expression vector pGEX to produce glutathione-S-transferase fusion proteins. Recombinant proteins were affinity purified and screened in ELISA with equine sera to identify immunoreactive polypeptides. The large envelope glycoprotein (GL) was identified as the most reactive to EAV-positive equine sera and an immunodominant epitope was mapped between amino acids 55 and 98 by subcloning and expression. A fusion protein covering this region and a GL-Specific synthetic peptide (residues 75 through 97) induced EAV-nentralizing antibody in vaccinated horses. The defined antigenic region of G L is likely to be exposed on the surface of the native EAV virion and consequently may be useful in the development of diagnostic tests and vaccines.

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“…The cells in the brain of the neonatal mice will be dividing, growing and differentiating and probably have an adequate proliferation of membranes for viral maturation. An induced membrane proliferation is also observed with Russian spring-summer encephalitis, St. Louis encephalitis and dengue-2 viruses (Murphy, 1980). In other virus infections such as mengovirus (Amako & Dales, 1967), vaccinia virus (Dales & Siminovitch, 1961) and poliovirus (Caliguiri & Tamm, 1970), initiation of RNA synthesis is associated with smooth membranes.…”

Section: Short Communicationmentioning

confidence: 79%