Toll-like receptor 2 and dectin-1 function as promising biomarker for Aspergillus fumigatus infection

Zhang, Pengpeng; X, Xin; Xu, Xiaoyong; Fang, Liping; Wu, Jie; Shi, Yi

doi:10.3892/etm.2017.5000

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…The results showed that PAMPs recognized by TLR2 upregulated IL-10 and decreased the recruitment of pulmonary eosinophils, thus downregulating Th2 response. 370 , 371 In allergic asthma, TLR9–IL-2 affects the Th2 response by regulating the expression of IL-17A, so small molecule inhibitors targeting TLR9 may become a new treatment strategy. 372 …”

Section: Prr-related Diseasesmentioning

confidence: 99%

Pattern recognition receptors in health and diseases

2021

Sig Transduct Target Ther

836

515

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Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged senescent cells. PRRs bridge nonspecific immunity and specific immunity. Through the recognition and binding of ligands, PRRs can produce nonspecific anti-infection, antitumor, and other immunoprotective effects. Most PRRs in the innate immune system of vertebrates can be classified into the following five types based on protein domain homology: Toll-like receptors (TLRs), nucleotide oligomerization domain (NOD)-like receptors (NLRs), retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), C-type lectin receptors (CLRs), and absent in melanoma-2 (AIM2)-like receptors (ALRs). PRRs are basically composed of ligand recognition domains, intermediate domains, and effector domains. PRRs recognize and bind their respective ligands and recruit adaptor molecules with the same structure through their effector domains, initiating downstream signaling pathways to exert effects. In recent years, the increased researches on the recognition and binding of PRRs and their ligands have greatly promoted the understanding of different PRRs signaling pathways and provided ideas for the treatment of immune-related diseases and even tumors. This review describes in detail the history, the structural characteristics, ligand recognition mechanism, the signaling pathway, the related disease, new drugs in clinical trials and clinical therapy of different types of PRRs, and discusses the significance of the research on pattern recognition mechanism for the treatment of PRR-related diseases.

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Section: Prr-related Diseasesmentioning

confidence: 99%

Pattern recognition receptors in health and diseases

2021

Sig Transduct Target Ther

836

515

View full text Add to dashboard Cite

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“…In a study of human umbilical vein endothelial cells infected with Aspergillus fumigatus , it was found that dectin-1 was able to bind to the surface of A. fumigatus and dispersed inside and outside the cell. The expression of dectin-1 in cells infected with Aspergillus fumigation was significantly higher than that in the control group ( Zhang et al., 2017 ). Previous in vivo studies have shown that mice without dectin-1 expression have significantly increased fungal load in lung tissue after nasal injection of Aspergillus fumigatus compared with wild-type mice ( Werner et al., 2009 ).…”

Section: Discussionmentioning

confidence: 93%

Diagnosis values of Dectin-1 and IL-17 levels in plasma for invasive pulmonary aspergillosis in bronchiectasis

Li²,

Cao³

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundAmong immunocompetent patients, patients with bronchiectasis are considered to be a high-risk group for invasive pulmonary aspergillosis (IPA). Early diagnosis and treatment can improve the prognosis of patients.ObjectivesWe aimed to investigate the diagnostic value of Dectin-1 and IL-17 for diagnosing IPA with bronchiectasis.MethodsWe retrospectively collected data on patients with bronchiectasis who had been hospitalized in the Third Affiliated Hospital of Soochow University between September 2018 to December 2021. Dectin-1, IL-17 and GM were measured by enzyme-linked immunosorbent assays.ResultsA total of 129 patients were analyzed in the study, of whom 33 had proven or probable IPA with bronchiectasis. The remaining 96 patients served as controls. The plasma Dectin-1 and IL-17 levels in the IPA group were significantly higher than that in the control group (P=0.005; P<0.001). The plasma GM, BALF GM, plasma Dectin-1 and IL-17 assays had sensitivities of 39.4%, 62.5%, 69.7% and 78.8%, respectively, and specificities of 89.2%, 91.5%, 72.9% and 71.9%, respectively. The sensitivity of Dectin-1 and IL-17 in plasma was higher than that in plasma and BALF GM. while the specificity is lower than that of plasma and BALF GM. The diagnostic sensitivity and specificity of plasma GM combined with IL-17 for IPA in bronchiectasis were greater than 80%. The combination of plasma GM and IL-17 can improve the sensitivity of the GM test, but does not reduce the diagnostic specificity. The plasma Dectin-1 and IL-17 showed positive linear correlations with the bronchiectasis severity Index (BSI) score in linear regression.ConclusionsPlasma Dectin-1 and IL-17 levels were significantly higher in bronchiectasis patients with IPA. The sensitivity of Dectin-1 and IL-17 was superior to that of GM for the diagnosis of IPA in patients with bronchiectasis. The combination of GM and IL-17 in plasma is helpful for the diagnosis of IPA in bronchiectasis patients who cannot tolerate invasive procedures.

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Toll-like receptor 2 and dectin-1 function as promising biomarker for Aspergillus fumigatus infection

Cited by 2 publications

References 25 publications

Pattern recognition receptors in health and diseases

Pattern recognition receptors in health and diseases

Diagnosis values of Dectin-1 and IL-17 levels in plasma for invasive pulmonary aspergillosis in bronchiectasis

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