Toll-like receptor 2 polymorphisms and their effect on the immune response to ESAT-6, Pam3CSK4 TLR2 agonist in pulmonary tuberculosis patients and household contacts

Mandala, Jyothi Priya; Ahmad, Shazia; Pullagurla, Ashwini; Thada, Shruthi; Joshi, Lavanya; Ansari, Mohd. Soheb Sadat; Valluri, Vijaya Lakshmi; Gaddam, Sumanlatha

doi:10.1016/j.cyto.2019.154897

Cited by 10 publications

(2 citation statements)

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“…Previous studies have found associations of NLRP3 and TLR2 polymorphisms with susceptibility to TB 5,[15][16][17]19,21 . In our study of the Taiwanese population, we found that the TC genotype of NLRP3 rs34298354 was associated with decreased risk of TB.…”

Section: Discussionmentioning

confidence: 94%

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The association of inflammasome and TLR2 gene polymorphisms with susceptibility to tuberculosis in the Han Taiwanese population

Liu

Lin

et al. 2020

Sci Rep

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Pulmonary tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is a global public health concern. Although inflammasome and the toll-like receptor 2 (TLR2) genes play an important role in host defense against Mtb, the associations of polymorphisms in these genes with TB risk are incompletely understood. A total of 230 TB patients and 213 individuals without TB were enrolled in this study. A significant difference in the frequencies of different AIM2 rs2276405 genotypes between the non-TB and TB groups was detected. When the patients were stratified by gender or age, significant differences in genotype frequencies at NLRP3 rs34298354 in men and in non-aged (≤65-year-old) subjects and at IFI16 rs1772408 in women were found. OR analysis showed that the TC rs34298354 genotype in NLRP3 was associated with reduced risk of TB. In women, the AG rs1772408 genotype in IFI16 was associated with decreased TB risk. Haplotype analysis showed that, in comparison with the most common haplotype (T-T) of rs3804099-rs3804100 in the TLR2 gene, the C-T haplotype was associated with an increased risk for TB. Our study indicates that rs34298354 in NLRP3 and rs1772408 in IFI16 protect individuals from TB, and that the less common TLR2 haplotype is associated with increased TB susceptibility.

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Section: Discussionmentioning

confidence: 94%

“…Genetic polymorphism of toll-like receptor 2 (TLR2), a TLR family member, influences the immune response to ESAT-6 in pulmonary tuberculosis patients 17 . TLRs are pattern recognition receptors expressed in antigen-presenting cells and are important in host immunity to infectious pathogens 18,19 .…”

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confidence: 99%